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Carrier diffusion effects in time-resolved photoluminescence (1992)

Bailey, D. W. ; Stanton, C. J.

Woodbury, NY : American Institute of Physics (AIP)

Applied Physics Letters 60 (1992), S. 880-882

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ISSN: 1077-3118

Source: AIP Digital Archive

Topics: Physics

Notes: We model time-resolved photoluminescence in GaAs using an ensemble Monte Carlo method coupled with a k⋅p calculation of the band structure. We show that on a picosecond scale, carrier diffusion perpendicular to the layer significantly reduces the density at the surface and consequently has a first-order effect on luminescence measurements. To illustrate this we compare the calculated luminescence, with and without diffusion, to experimental data.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.106492

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Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics on felodipine — and its potential clinical relevance (1992)

Edgar, B. ; Bailey, D. ; Bergstrand, R. ; [et al.]

Springer

European journal of clinical pharmacology 42 (1992), S. 313-317

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ISSN: 1432-1041

Keywords: Dihydropyridine ; Felodipine ; availability ; flavonoids ; dietary interaction ; pharmacokinetics ; pharmacodynamics ; adverse effects

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The effect of drinking grapefruit juice on the acute pharmacokinetic and haemodynamic actions of the dihydropyridine calcium antagonist felodipine given as a 5 mg plain tablet has been studied in nine, healthy, middle-aged males. Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol · l−1, and in the AUC from 23 to 65 nmol · h · l−1. The change in AUC corresponded to an increase in the systemic availability of felodipine from 15 to 45%, assuming no change in its clearance. This change was probably caused by inhibition of the oxidation of felodipine to the inactive dehydrofelodipine by flavonoids in grapefruit juice. The interaction with grapefruit juice is believed to be a class effect for the dihydropyridines, as oxidation of the dihydropyridine ring to the corresponding pyridine derivative is a major metabolic route for all these drugs. The higher plasma concentrations of felodipine taken with grapefruit juice resulted in a greater change in blood pressure measured in the morning 3 h after dosing (−9%) than did water (0%).