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  • 1990-1994  (5)
  • 1985-1989
  • 1994  (5)
  • Conidiation  (1)
  • H+-ATPase  (1)
  • Life and Medical Sciences  (1)
  • Mathematics Subject Classification (1991): 65D07, 65D17, 41A15, 15A48  (1)
  • Poisson process  (1)
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Material
Years
  • 1990-1994  (5)
  • 1985-1989
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Characterizations of the Poisson process as a renewal process via two conditional moments (1994)
    Springer
    Annals of the Institute of Statistical Mathematics 46 (1994), S. 351-360 
    Details
    ISSN: 1572-9052
    Keywords: Characterization ; exponential distribution ; gamma distribution ; geometric distribution ; Poisson process ; renewal process
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Given two independent positive random variables, under some minor conditions, it is known that fromE(Xr∥X+Y)=a(X+Y)r andE(Xs∥X+Y)=b(X+Y)s, for certain pairs ofr ands, wherea andb are two constants, we can characterizeX andY to have gamma distributions. Inspired by this, in this article we will characterize the Poisson process among the class of renewal processes via two conditional moments. More precisely, let {A(t), t≥0} be a renewal process, with {S k, k≥1} the sequence of arrival times, andF the common distribution function of the inter-arrival times. We prove that for some fixedn andk, k≤n, ifE(S k r ∥A(t)=n)=atr andE(S k s ∥A(t)=n)=bts, for certain pairs ofr ands, wherea andb are independent oft, then {A(t), t≥0} has to be a Poisson process. We also give some corresponding results about characterizingFto be geometric whenF is discrete.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720591
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Least supported bases and local linear independence (1994)
    Springer
    Numerische Mathematik 67 (1994), S. 289-301 
    Details
    ISSN: 0945-3245
    Keywords: Mathematics Subject Classification (1991): 65D07, 65D17, 41A15, 15A48
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary. We introduce the concept of least supported basis, which is very useful for numerical purposes. We prove that this concept is equivalent to the local linear independence of the basis. For any given locally linearly independent basis we characterize all the bases of the space sharing the same property. Several examples for spline spaces are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002110050029
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic requirements for initiating asexual development in Aspergillus nidulans (1994)
    Springer
    Current genetics 27 (1994), S. 62-69 
    Details
    ISSN: 1432-0983
    Keywords: Conidiation ; Fungi ; brlA ; Microbial development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Conidiation in the filamentous ascomycete Aspergillus nidulans requires activation of brlA, a well-characterized transcriptional regulator of genes that are induced specifically during asexual development. We have isolated and characterized developmental mutations in six loci, designated fluG, flbA, flbB, flbC, flbD, and flbE, that result in defective development and reduced brlA expression. These mutants grow indeterminately to produce masses of aerial hyphae resulting in the formation of cotton-like colonies with a “fluffy” morphology. The results of growth and epistasis tests involving all pairwise combinations of fluffy mutations indicate complex hierarchical relationships among these loci. We discuss these genetic interactions and propose that there are multiple mechanisms for activating brlA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326580
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  • 4
    Electronic Resource
    Electronic Resource
    Modeling a conformationally sensitive region of the membrane sector of the fungal plasma membrane proton pump (1994)
    Springer
    Journal of bioenergetics and biomembranes 26 (1994), S. 101-115 
    Details
    ISSN: 1573-6881
    Keywords: H+-ATPase ; molecular modeling ; helical hairpin ; aromatic slipper ; coupling ; molecular dynamics ; yeast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract A molecular model for transmembrane segments 1 and 2 from the fungal proton pumping ATPase has been developed, and this structure is predicted to form a helical hairpin loop structure in the membrane. This region was selected because it is highly conformationally active and is believed to be an important site of action for clinically important therapeutics in related animal cell enzymes. The hairpin loop is predicted to form an asymmetric tightly packed structure that is stabilized by an N-cap between D140 and V142, by hydrogen bonding between residues in the turn region and the helices, and by π-π interactions between closely apposed aromatic residues. A short four-residue S-shaped turn is stabilized by hydrogen bonding but is predicted to be conformationally heterogeneous. The principal effect of mutations within the hairpin head region is to destabilize the local close packing of side groups which disrupts the pattern of hydrogen bonding in and around the turn region. Depending on the mutation, this causes either a localized or a more global distortion of the primary structure in the hairpin region. These altered structures may explain the effects of mutations in transmembrane segments 1 and 2 on ATP hydrolysis, sensitivity to vanadate, and electrogenic proton transport. The conformational sensitivity of the hairpin structure around the S-turn may also account for the effects of SCH28080 and possibly ouabain in blocking ATPase function in related animal cell enzymes. Finally, the model of transmembrane segments 1 and 2 serves as a template to position transmembrane segments 3 and 8. This model provides a new view of the H+-ATPase that promotes novel structure/function experimentation and could serve as the basis for a more detailed model of the membrane sector of this enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00763222
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  • 5
    Electronic Resource
    Electronic Resource
    Demethylation in the 5′-flanking region of mouse cellular retinoic acid binding protein-I gene is associated with its high level of expression in mouse embryos and facilitates its induction by retinoic acid in P19 embryonal carcinoma cells (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 201 (1994), S. 1-10 
    Details
    ISSN: 1058-8388
    Keywords: CRABP-I ; P19 cells ; DNA methylation ; Gene expression ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The mouse cellular retinoic acid binding protein-I (CRABP-I) gene is specifically up-regulated by retinoic acid (RA) in P19 mouse embryonal carcinoma cells, and its expression in animals is spatially and temporally restricted to RA-sensitive tissues during embryonic development. This study demonstrates that, in adult mouse tissues and P19 cells where the expression of CRABP-I is detected at the basal level, the 5′- flanking region of the CRABP-I gene is hypermethylated at the C residues of all the Hpa II sites. Conversely, in mouse embryos during early stages of development when the expression of CRABP-I gene is detected at a much higher level, this region is demethylated at these Hpa II sites. In P19, enhancement on the RA-induced up-regulation of CRABP-I can be observed in cells treated with 5-azacytidine (5-AzaC) in conjunction with RA, where partial demethylation in the 5′-flanking region of CRABP-I gene is observed. Nuclear run-on experiments indicate that increased message levels of CRABP-I in P19 cells can be accounted for, at least partially, by increases in its transcription rates. The induction of retinoic acid receptor (RAR) β by RA can also be enhanced by 5-AzaC, but to a much lesser degree. In contrast, all the Hpa II sites in the structural gene portion, at least in the first two exons, are fully demethylated at the C residues. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1002010102
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