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  • 1
    Electronic Resource
    Electronic Resource
    Occurrence of deficient galactosylation of serum IgG prior to the onset of rheumatoid arthritis (1994)
    Springer
    Rheumatology international 13 (1994), S. 217-220 
    Details
    ISSN: 1437-160X
    Keywords: Galactosylation of IgG ; Rheumatoid arthritis ; Pima and Papago Indians
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous reports have shown that deficient galactosylation of serum IgG occurs in patients with rheumatoid arthritis (RA) and other autoimmune disorders. In this study, we investigated the relationship between galactosylation of serum IgG and disease status in a population of Pima and Papago Indians, who are characterized by a frequent occurrence of RA. The mean galactose levels of serum IgG collected from 11 individuals 1.5–10 years prior to onset (T1), at onset (T2), and 1.7–7 years post-onset (T3) of RA were lower than those from 25 seronegative controls without RA from the same population (P=0.01, 0.005, and ≦0.001, respectively). The mean galactose content of IgG decreased in the order T1〉T2〉T3, but the differences were not significant. The galactosylation of serum IgG from the RA patients did not differ from that of seropositive Pima Indian controls who did not develop RA over the course of study. The occurrence of IgG galactose deficiency in individuals with RA prior to the onset of the disease supports the contention that this phenomenon may be a risk factor for the development of RA. Furthermore, the occurrence of IgG galactose deficiency in healthy seropositive individuals suggests a relationship between diminished galactosylation and induction of rheumatoid factor (RF).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290198
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 617-623 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus, risk factors, glucose, insulin, childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metabolic abnormalities antedate the development of non-insulin-dependent diabetes mellitus (NIDDM) by some years. How these metabolic abnormalities relate to the genetic component of the disease and to the subsequent prediction of diabetes is unknown. The present study was designed to examine the association of parental diabetes with relative weight, fasting and 2-h plasma glucose and fasting and 2-h serum insulin in childhood, and to identify which of these variables were most predictive of subsequent NIDDM. Subjects comprised 1258 Pima Indians aged 5–19 years with normal glucose tolerance participating in a longitudinal population-based study. Age-sex-adjusted values of relative weight, fasting and 2-h glucose and fasting and 2-h insulin were positively associated with parental diabetes. Only one of 138 subjects with two non-diabetic parents developed diabetes. Among 1120 subjects with at least one diabetic parent, 101 (9.0 %) developed diabetes during a mean follow up of 8.4 years. Fasting insulin was a significant predictor of diabetes, but did not add to the predictive value of relative weight. Relative weight and 2-h and fasting plasma glucose were the variables most predictive of NIDDM in childhood and adolescence. Against a background of parental diabetes, high fasting insulin concentrations predict diabetes, compatible with the hypothesis that insulin resistance is an early metabolic abnormality leading to NIDDM. In this study, however, its predictive power did not add significantly to that of relative weight, with which it was correlated. Both relative weight and 2-h plasma glucose in youth in those with diabetic parents are highly predictive of subsequent diabetes, and these may be the best measures currently available for identifying high-risk subjects in whom preventive measures might be targeted. [Diabetologia (1994) 37: 617–623]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403382
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 617-623 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; risk factors ; glucose ; insulin ; childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metabolic abnormalities antedate the development of non-insulin-dependent diabetes mellitus (NIDDM) by some years. How these metabolic abnormalities relate to the genetic component of the disease and to the subsequent prediction of diabetes is unknown. The present study was designed to examine the association of parental diabetes with relative weight, fasting and 2-h plasma glucose and fasting and 2-h serum insulin in childhood, and to identify which of these variables were most predictive of subsequent NIDDM. Subjects comprised 1258 Pima Indians aged 5–19 years with normal glucose tolerance participating in a longitudinal population-based study. Age-sex-adjusted values of relative weight, fasting and 2-h glucose and fasting and 2-h insulin were positively associated with parental diabetes. Only one of 138 subjects with two non-diabetic parents developed diabetes. Among 1120 subjects with at least one diabetic parent, 101 (9.0%) developed diabetes during amean follow up of 8.4 years. Fastinginsulin was a significant predictor of diabetes, but did not add to the predictive value of relative weight. Relative weight and 2-h and fasting plasma glucose were the variables most predictive of NIDDM in childhood and adolescence. Against a background of parental diabetes, high fasting insulin concentrations predict diabetes, compatible with the hypothesis that insulin resistance is an early metabolic abnormality leading to NIDDM. In this study, however, its predictive power did not add significantly to that of relative weight, with which it was correlated. Both relative weight and 2-h plasma glucose in youth in those with diabetic parents are highly predictive of subsequent diabetes, and these may be the best measures currently available for identifying high-risk subjects in whom preventive measures might be targeted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403382
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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