ISSN:
1432-069X
Keywords:
Bradykinin receptor
;
Progressive systemic sclerosis
;
Fibroblast
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The numbers of bradykinin receptors (BK-R) in cultured dermal fibroblasts from patients with progressive systemic sclerosis (PSS) and from healthy controls were measured using a receptor binding assay. The numbers of BK-R were significantly fewer in PSS fibroblasts than in control fibroblasts (P〈0.02). However, no differences in affinity were observed in BK-R between PSS and control fibroblasts. The BK-R mRNA levels were determined in PSS and control fibroblasts by Northern blot hybridization using BK-R cDNA, but no significant differences were found. These findings suggest that the decrease in BK-R in PSS fibroblasts might occur during a posttranslational step.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00374207
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