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  • 1
    Electronic Resource
    Electronic Resource
    Dysphagia caused by an anterior cervical osteophyte: case report (1995)
    Springer
    Neuroradiology 37 (1995), S. 58-59 
    Details
    ISSN: 1432-1920
    Keywords: Cervical spondylosis ; Dysphagia ; Ankylosing hyperostosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cervical spondylosis and ankylosing hyperostosis of the cervical vertebrae are commonly asymptomatic. Dysphagia caused by cervical osteophyte formation is rare. We report a case of spondylotic dysphagia with striking radiographic findings. A massive anterior cervical hyperostosis was resected via the anterior cervical approach with excellent relief of dysphagia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588521
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Scopolamine prevents augmentation of stereotypy induced by chronic methamphetamine treatment (1995)
    Springer
    Psychopharmacology 121 (1995), S. 158-163 
    Details
    ISSN: 1432-2072
    Keywords: Methamphetamine ; Behavioral sensitization ; Scopolamine ; Acetylcholine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether scopolamine, a muscarinic cholinergic antagonist, would also block augmentation of stereotypy induced by chronic methamphetamine (MA) treatment. Rats treated with MA (2.5 mg/kg, SC) for 10 days indicated significantly enhanced stereotyped behavior when tested with MA (2.5 mg/kg) after a 7-to 8- day withdrawal. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the augmentation of stereotypy. Rats treated with scopolamine alone showed no difference in MA-induced stereotypy compared to those treated with saline. Scopolamine methylbromide, a derivative of scopolamine that does not easily cross the blood-brain barrier, had no effect on the augmentation of stereotypy. These results suggest that stimulation of central muscarinic cholinergic receptors plays a role in the development of sensitization to the stereotypy stimulating effect of methamphetamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245625
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of [3H]clozapine binding sites in rat brain (1995)
    Springer
    Journal of neural transmission 101 (1995), S. 51-64 
    Details
    ISSN: 1435-1463
    Keywords: [3H]clozapine binding ; serotonin 5-HT2 receptor ; dopamine D4 receptor ; frontal cortex ; limbic area
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the characteristics of [3H]clozapine binding sites in four rat brain regions (frontal cortex, limbic area, hippocampus and striatum) in order to elucidate the pharmacological profile of this unique atypical antipsychotic drug. The specific [3H]clozapine binding was found to be saturable and reversible in all these brain regions. Scatchard analysis of the saturation data indicated that the specific binding consisted of high- and low-affinity components. Displacement experiments showed that the muscarinic cholinergic receptor represented about 50% of [3H]clozapine binding in each brain area. Serotonin 5-HT2 and dopamine D4 receptor binding sites could also be detected by displacement experiments using ketanserin and nemonapride, respectively, in frontal cortex and limbic area, but not in hippocampus or striatum. Alpha-1, alpha-2, histamine H1, dopamine D1, D2, or D3 receptor components could not be determined within the high-affinity [3H]clozapine binding sites in any brain region. It is possible that the atypical property of clozapine may depend on the modulatory effect on dopaminergic function via 5-HT2 receptor blockade and/or may be mediated via D4 receptor blockade in the mesocortical and mesolimbic area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271545
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Long-term treatment with haloperidol or clozapine does not affect dopamine D4 receptors in rat frontal cortex (1995)
    Springer
    Journal of neural transmission 101 (1995), S. 231-235 
    Details
    ISSN: 1435-1463
    Keywords: [3H]clozapine ; dopamine D4 receptor ; frontal cortex ; haloperidol ; clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the effects of long-term treatment with haloperidol and clozapine on dopamine D4 receptors in rat frontal cortex. Dopamine D4 receptor binding sites were indirectly determined from the displacement experiments of [3H]clozapine binding using nemonapride. Three-weeks administration of haloperidol (0.5mg/kg) or clozapine (10mg/kg) did not significantly affect the D4 receptors in the frontal cortex. The density of D2 receptors, determined by [3H]spiperone binding to striatum, was increased by long-term treatment with haloperidol, but it was not significantly changed by that with clozapine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271560
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    Paper (German National Licenses)
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