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  • 1995-1999  (10)
  • 1985-1989
  • 1980-1984
  • 1996  (10)
  • 1
    Electronic Resource
    Electronic Resource
    The disturbance of epidermal barrier function in atopy patch test reactions in atopic eczema (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Atopic eczema (AE) is a common skin disorder. Eczematous lesions showing macroscopic, microscopic and immunopathological resemblance to lesional AE can be induced by aeroallergens by epicutaneous testing (atopy patch test, APT). Altered epidermal barrier function, as determined by transepidermal water loss (TEWL), is a typical feature of patients with AE. The present investigation was performed to define the differences in the epidermal barrier function between positive APT reactions to aeroallergens and positive patch test reactions to contact allergens in AE patients. Allergen extracts from grass pollen, birch pollen, cat dander and house dust mite (Dermatophagoides pteronyssinus) were applied in large Finn chambers on Scanpor for 48h on the clinically unaffected and untreated skin of the back, in 11 patients with AE. The same procedure was done with 27 contact allergens of a standard test battery. Test reactions were read and TEWL was measured after 48 and 72h. Eight of the 11 patients developed positive APT reactions toD. pteronyssinus, two to cat dander and one to birch pollen. Seven of the 11 patients showed positive patch test reactions to nickel sulphate, two to potassium dichromate, one to thiuram-mix and one to paraphenylenediamine. Vehicle controls were negative. The TEWL of the positive APT reactions was significantly higher, both after 48 h (mean ± standard deviation 10·0±6·5 g/m2h) and after 72 h (9·7±5·4g/m2h) as compared with the control site (48/72h: 4·4±1.5/4·1±1·4 g/m2h) (P〈0·01). In contrast, TEWL of the positive patch test reactions to contact allergens (48/72h; 5·4±2·2/5·4±1·9g/m2h) was similar to that of the control site (48/72 h: 5·2±2·1/5·0± 1·8g/m2h) (not significant). The relative TEWL at 48 h and 72 h, expressed as the ratio between the positive patch test and the control site, was significantly higher in the positive APT reactions (48/72 h: 218·8±80·4%/232·0±85·9%) compared with positive patch test reactions to contact allergens (48/72 h: 102·1±12·0%/107·1±9·5%) (P〈0·01). It is concluded that the epidermal barrier function in AE patients is altered only in positive APT reactions, in contrast to positive patch test reactions to contact allergens. As a consequence of this aeroallergen-induced altered epidermal barrier function, further allergens can more easily penetrate the skin, inducing a vicious circle and perpetuating the eczematous lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1040.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunoreactivity of glycoprotein lib is present in metastasized but not in non-metastasized primary malignant melanoma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Glycoprotein Ilb-IIIa (integrin alpha lib beta3) is an adhesive receptor involved in platelet aggregation and adhesion to the extracellular matrix. Previous.studies showed the presence of IIb-IIIa-like glycoproteins on cells of melanoma cell lines and on cells of lymph node metastases. This study evaluates the presence of glycoprotein IIb-IIIa subunits on cells of primary cutaneous malignant melanomas wilh (n= 4) and without (n= 9) metastases over a period of 6 years and on naevus cells (n= 4). Monoclonal antibodies directed against the subunits of the glycoprotein IIb-IIIa receptor were used on paraffin-embedded sections and evaluated by means of immuno-histochemistry. The giycoprotein lib subunit was exclusively present on cells of metastatic melanomas. It was not found on non-metastatic melanomas or benign melanocytes. These data favour the role of the integrin receptor glycoprotein IIb-IIIa in the metastatic behaviour of malignant melanomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1090.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The atopy patch test: an increased rate of reactivity in patients who have an air-exposed pattern of atopic eczema (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In a subgroup of patients with atopic eczema (AE), eczematous skin lesions can he induced by epicutaneous testing with aeroallergens (the atopy patch test: APT). An increased frequency of positive APT has been found in AK patients showing a predictive lesional pattern affecting air-exposed skin areas. This study investigates the dose-response ofthe APT in two dilTerent patient groups with AE. Petrolatum preparations of house dust mite, cat dander and grass pollen allergens in four concentrations (500–10,000) protein nitrogen imits) were tested epicutaneously in 57 patients with AE. who were prospectively divided in two groups according to whether their AE pattern was with (group I) or without (group II) a predictive distribution. Sixty-nine per cent of patients in group I. and 39% in group II. had positive APT reactions (P = 0.02). The reactions in group I were elicitable with lower allergen concentrations (P = 0.03). A clinically recognizable subgroup of patients with AE showed increased cutaneous sensitivity to aeroallergens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb01144.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Histopathological and epidemiological characteristics of patients with erythema exudativum multiforme major, Stevens—Johnson syndrome and toxic epidermal necrolysis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The clinical and histopathological classification of erythema exudativum multiforme major (EEMM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are difficult, due to the lack of clear-cut criteria. Based on a new clinical classification, 149 of 219 (68%) histopathological specimens, from a total of 534 patients with EEMM. SJS and TEN, have been reviewed. A comparison was made with the clinical picture, and any past history of infection or drug intake. All patients had been included in the German Registry of Severe Skin Reactions between April 1990 and December 1993. No differences could be found between the biopsies examined and the total number of histopathological specimens, concerning clinical diagnosis, gender and age. Sections from 28 of 149 specimens were not diagnostic or were too old to be properly evaluated. In nine cases, other diagnoses were proposed. One hundred and eleven of the histological slides with the diagnosis of EEMM (n= 16), SJS (n=34) and TEN (n=61), were classified as epidermal type of erythema multiforme. In these 111 slides, necrotic keratinocytes could be found, ranging from individual cells to confluent epidermal necrosis. The epidermo-dermal junction showed changes ranging from vacuolar alteration up to subepidermal blisters. The dermal infiltrate was superficial and mostly perivascular. It was sparse in SJS and TEN, and more pronounced in EEMM. Oedema in the papillary dermis was evident occasionally in all clinical groups. In 59 of 111 cases (53%), at least one eosinophil was present in the dermis. In 11 of 111 (10%), more than 10 eosinophils per field could be seen. Eosinophils were less common in the patients with the most severe forms of TEN, in whom there was detachment of more than 30% of the skin surface area. No differences in the history for drug intake, or for infection with Mycoplasma pneumoniae, herpes simplex and other organisms, could be detected between patients with or without eosinophils in their skin sections. This dermatopathological study of patients with EEMM. SJS and TEN indicates that the epidermal type of erythema multiforme is the pathological correlate for these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-924.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Trichloroethylene and concomitant contact dermatitis in an art painter (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 34 (1996), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1996.tb02250.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The therapeutic concept of “patient management” in atopic eczema (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04595.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Atopic eczema and other manifestations of atopy: results of a study in East and West Germany (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Within an environmental health study, dermatologic examination of 1273 pre-school-age children (5–7 years old) was carried out in selected areas of East (n= 287) and West (n= 987) Germany in spring 1991. On the basis of comparable genetic background, the influence of a different exposure to air pollutants on the manifestation of atopic diseases was investigated. Halle an der Saale (East Germany) and Duisburg (North/South) as well as Essen (West Germany) were chosen as polluted study areas, whereas the countryside town of Borken (West Germany) served as a control region. Outdoor pollution with particles and SO2 was significantly higher in Halle an der Saale. Of the total study group. 12.9% suffered from atopic eczema at the time of examination. The prevalence was highest in East Germany (17.5%; adjusted odds ratio [OR] 1.39, confidence intervals [CI] 0.77–2.52, compared to Borken). The reported frequencies of hay fever and asthma in the total study population were 2% and 1.3%, respectively, without significant differences between study sites. Some 34.7% of the children showed at least one positive skin prick test reaction; significantly (P〈 0.001) higher sensitization rates were obtained in western regions (Essen, Duisburg-South) than in the control region (Borken) and East Germany. Multivariate analysis of the prevalence of atopic eczema showed associations with parental predisposition (OR 1.52, CI 1.03–2.25), sex (for boys, OR 0.63, CI 0.43–0.92), location (Duisburg-South vs Borken OR 0.52, CI 0.30–0.96). month of investigation (May vs April, and March vs February OR 0.55, CI 0.37–0.81), contact with rabbits (for girls, OR 2.90, CI 1.36–6.19), animal fur in bedrooms (2.17, 1.01–4.67), indoor use of gas without hood (1.68, 1.11–2.56), and distance of homes from a busy road (〈50 m 1.71, 1.07–2.73). Nonsignificant associations were observed for history of helminthic infections (OR 1.61, CI 0.98–2.64) and high parental education level (OR 1.83, CI 0.83–4.02). In East and West Germany, atopic eczema seems to follow a course different from that of respiratory allergic diseases and specific sensitization, a fact which underlines the need for a differentiated analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04665.x
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  • 8
    Electronic Resource
    Electronic Resource
    Tryptase concentration in skin blister fluid from patients with bullous skin conditions (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 771-773 
    Details
    ISSN: 1432-069X
    Keywords: Key words Tryptase ; Mast cells ; Allergic contact ; dermatitis ; Bullous pemphigoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050139
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  • 9
    Electronic Resource
    Electronic Resource
    1. Otto Braun-Falco – Alumni-Vorlesung Tübingen 26. April 1996 K. Wolff: Prävention in der Dermatologie (1996)
    Springer
    Der Hautarzt 47 (1996), S. 873-873 
    Details
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050527
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Die Behandlung des atopischen Ekzems in interdisziplinärer Zusammenarbeit zwischen Dermatologie und Psychosomatik Eine Einzelfalldarstellung (1996)
    Springer
    Der Hautarzt 47 (1996), S. 628-633 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Atopisches Ekzem ; Nahrungsmittelallergie ; Psychosomatik ; Mutter-Kind-Beziehung ; Key words Atopic eczema ; Food allergy ; Psychosomatics ; Mother-child relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Atopic eczema is one of the most frequent dermatological diseases, with a still increasing incidence. Although its etiopathogenesis is still not completely understood, a variety of triggering factors are known. The following case report describes the clinical course of atopic dermatitis in a 2-year-old boy in whom both IgE-mediated allergic reactions and psychological factors were involved in triggering and maintenance of skin lesions. This demonstrates how important both dermatological therapy and close cooperation with the field of psychosomatic medicine can be.
    Notes: Zusammenfassung Das atopische Ekzem zählt zu den häufigsten dermatologischen Erkrankungen mit zunehmender Inzidenz. Obwohl die Ätiopathogenese letztendlich ungeklärt ist, sind eine Vielzahl auslösender Faktoren bekannt. Anhand der Falldarstellung eines 2jährigen Kindes, bei dem sowohl IgE-vermittelte allergische Reaktionen als auch psychische Faktoren an der Auslösung und Unterhaltung der Hautveränderungen beteiligt waren, soll aufgezeigt werden, daß eine erfolgreiche Behandlung des atopischen Ekzems in vielen Fällen neben dermatologisch-allergologischen Therapieansätzen ebenso eine enge Kooperation mit dem Fachgebiet der Psychosomatik erforderlich macht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050480
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