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  • 1995-1999  (3)
  • 1960-1964
  • 1997  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Anti-granulocyte antibody suppression of active and passive anaphylactic shock in WBB6F1-W/Wv mice (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 663-666 
    Details
    ISSN: 1420-9071
    Keywords: Key words. PAF; anaphylactic shock; WBB6F1-W/Wv; anti-mouse granulocyte antibody.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Our previous study revealed that anaphylac tic shock can be produced in WBB6F1-W/Wv (abbreviated as W/Wv) mice. Because they are congenitally deficient in mast cells, we are certain that some other cell types are involved as mediator sources. In the present study, with the aim of examining the role of circulatory granulocytes, the effect of monoclonal an tibody to a mouse granulocyte antigen, Gr-1, upon active and passive anaphylactic shock was tested in W/Wv mice using several mast cell-bearing strains as references. An intravenous injection of 40 μg of anti-granulocyte antibody one day before the antigen chal lenge produced a marked decrease in neutrophils and nearly complete abolition of lethal shock in W/Wv mice regardless of the sensitizing method. Both pre vention of shock and reduction of neutrophils lasted for three days after the treatment with the antibody but not for six days. From these results, a reasonable conclusion would be that circulating Gr-1+ cells (predominantly composed of neutrophils) are the major mediator source. Reference experiments using mast cell-bearing strains revealed that the suppressive effect of anti-granulocyte antibody was also observed against active anaphylactic shock in C3H/HeN mice but not against active and passive anaphylactic shock in the other mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050085
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Biochemical and molecular analysis of an X-linked case of Leigh syndrome associated with thiamin-responsive pyruvate dehydrogenase deficiency (1997)
    Springer
    Journal of inherited metabolic disease 20 (1997), S. 539-548 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report molecular analysis of thiamin-responsive pyruvate dehydrogenase complex (PDHC) deficiency in a patient with an X-linked form of Leigh syndrome. PDHC activity in cultured lymphoblastoid cells of this patient and his asymptomatic mother were normal in the presence of a high thiamin pyrophosphate (TPP) concentration (0.4 mmol/L). However, in the presence of a low concentration (1 X 10-4 mmol/L) of TPP, the activity was significantly decreased, indicating that PDHC deficiency in this patient was due to decreased affinity of PDHC for TPP. The patient's older brother also was diagnosed as PDHC deficiency with Leigh syndrome, suggesting that PDHC deficiency in these two brothers was not a de novo mutation. Sequencing of the X-linked PDHC E1 α subunit revealed a C → G point mutation at nucleotide 787, resulting in a substitution of glycine for arginine 263. Restriction enzyme analysis of the E1α gene revealed that the mother was a heterozygote, indicating that thiamin-responsive PDHC deficiency associated with Leigh syndrome due to this mutation is transmitted by X-linked inheritance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005305614374
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Stochastic analysis on crack path of polycrystalline ceramics based on the difference between the released energies in crack propagation (1997)
    Springer
    Journal of materials science 32 (1997), S. 2341-2346 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The crack path of polycrystalline ceramics has been theoretically analysed with a stochastic model based on the difference between the released energies in intergranular and transgranular crack propagation. Assuming that the path with the lowest released energy should be realized as the actual crack path, the expected values of the fraction of transgranular fracture on fracture surface and the fracture toughness of polycrystalline ceramics were formulated as functions of grain size and the critical energy release rates of grain and grain boundary. By comparison between the theory and the experimental results it was shown that the stochastic model proposed here expressed the change of the crack path and the fracture toughness of polycrystalline Al2O3, relative to grain size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018588620081
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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