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  • 1
    Electronic Resource
    Electronic Resource
    Some alterations of the leucoeyte β2-adrenoceptor/cAMP-system in patients with seasonal allergic rhinoconjunctivitis are related to disease activity (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Disturbances of β2-adrenoceptors are discussed as a pathogenic factor in atopic diseases.Methods In this study tbe expression and function of β2-adrenoceptors on peripheral blood leucocytes (PBL) of seven atopic patients with seasonal rhinoconjunctivitis and their seven healthy controls was evaluated in relation to disease activity. Earlier reported data during pollen. season were now compared with data obtained from the same subjects after their allergic symptoms had subsided.Results The variables that had indicated a β2-adrenoceptor subsensitivity in tbe patients during pollen season returned to control values, i.e. the reduced β2-adrenoceptor affinity, the reduced β2-adrenoceptor sensitivity, the reduced increase of intracellular cyclic adenosine monophosphate (cAMP) content upon stimulation with isoproterenol, and the reduced cAMP plasma concentration (values no longer significantly different from those of controls). However, the variable that had suggested an increase in activity of the cAMP degrading enzyme phosphodiesterase (PDE), i.e. the reduced basal intracellular cAMP content of the patients, remained reduced after the pollen season (4.9 ± 1.1 pmol/lO6’cells in patients vs 8.2 ± 0.9pmol/106 cells in controls: P 〈 0.05). There were no significant differences in β2-adrenoceptor density between patients and controls at both investigations.Conclusions Atopic seasonal rhinoconjunctivitis is associated with various alterations in the PBL β2-adrenoceptor/cAMP system that depend on disease activity. The reversible β2-adrenoceptor subsensitivity is likely to be a consequence of the disease, whereas the irreversibly decreased basal intracellular cAMP content, suggested an elevated PDE activity, might be a basic trait of atopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.1997.5108777.x
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  • 2
    Electronic Resource
    Electronic Resource
    Epidurale Lipomatose als Komplikation der Glukokortikoidbehandlung (1997)
    Springer
    Der Hautarzt 48 (1997), S. 787-790 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Epidurale Lipomatose ; Glukokortikoidtherapie ; Glukokortikoidnebenwirkung ; Key words Epidural lipomatosis ; Glucocorticoid therapy ; Glucocorticoid side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Epidural lipomatosis can be induced by systemic glucocorticoid treatment and may cause severe neurologic deficits. So far, 41 patients have been reported in the literature. Early recognition of this rare, relatively unknown, but extremely important side effect of exogenously administered glucocorticoids can help avoid persistent neurological sequeloe.
    Notes: Zusammenfassung Die epidurale Lipomatose kann im Rahmen einer systemischen Glukokortikoidtherapie auftreten und neurologische Ausfallserscheinungen verursachen. Bisher wurde über 41 Patienten in der Literatur berichtet. Rechtzeitiges Erkennen dieser zwar seltenen und daher relativ unbekannten, aber äußerst bedeutsamen Nebenwirkung von exogen zugeführten Glukokortikoiden kann vor irreversiblen neurologischen Ausfällen bewahren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050661
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    Paper (German National Licenses)
    Fulltext
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