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  • 2000-2004
  • 1995-1999  (4)
  • 1990-1994
  • 1975-1979
  • 1998  (4)
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  • 2000-2004
  • 1995-1999  (4)
  • 1990-1994
  • 1975-1979
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  • 1
    Electronic Resource
    Electronic Resource
    c-erbB-2 protein is expressed in hepatolithiasis and cholangiocarcinoma (1998)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 33 (1998), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The c-erbB-2 proto-oncogene encodes a transmembrane protein which is highly homologous to epidermal growth factor receptor. Overexpression of this c-erbB-2 protein has been reported in many human carcinomas, including breast carcinoma. However, there have been few studies of the expression of c-erbB-2 in cholangiocarcinoma and hepatolithiasis, a condition occasionally associated with cholangiocarcinoma.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsIn this study, we evaluated immunoreactivity for the c-erbB-2 protein in human cholangiocarcinomas (n = 47), hepatolithiasis (n = 20), fetal livers (n = 36) and normal adult livers (n = 6). In normal adult livers and fetal livers, expression of c-erbB-2 protein could not be detected in hepatocytes or intrahepatic biliary cells. In hepatolithiasis, there was overexpression of c-erbB-2 in 15/20 (75%). The expression was found with a membranous pattern on the proliferated intrahepatic bile ducts and proliferated intrahepatic peribiliary glands around the bile ducts containing stones. Hepatocytes were negative for c-erbB-2 protein. Moreover, the biliary cell expression of the c-erbB-2 protein correlated significantly with Ki67 labelling index. On the other hand, aberrant expression of c-erbB-2 was found in 33/47 (70%) cholangiocarcinomas. The c-erbB-2 expression in cholangiocarcinomas did not correlate with Ki67 labelling index or p53 expression.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsThese results indicate that aberrant expression of c-erbB-2 protein is found in cholangiocarcinoma and also in noncancerous biliary proliferative lesions such as hepatolithiasis. These findings also suggest that c-erbB-2 oncogene participates not only in cholangiocarcinogenesis but also in biliary cell proliferation in non-neoplastic conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1998.00496.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Infrared Sensor Using Thin Film Ceramic Semiconductor (1998)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 159-160 (May 1998), p. 305-310 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.159-160.305.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    STM/STS and the first principles calculations on Al/Si(001)2×1 (1998)
    Springer
    Applied physics 66 (1998), S. S145 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 61.16.-d; 68.35.Bs; 73.20.At
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: 9  atoms/cm2. In this study, in order to achieve an elementary analysis of each atom on the Si surface, metal atoms on the Si(001) surface are analyzed by STS and the result is evaluated with the first principles calculations of quantum mechanics. As metallic contaminations, sub-monolayer of Aluminum is evaporated on Si(001)2×1. The Local Density of State (LDOS) on the Al/Si(001)2×1 is measured by STS at room temperature. The measured LDOS at an Al dimer is in good agreement with that obtained from the calculation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390051118
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  • 4
    Electronic Resource
    Electronic Resource
    Antibody-dependent difference in biodistribution of monoclonal antibodies in animal models and humans (1998)
    Springer
    Cancer immunology immunotherapy 46 (1998), S. 311-317 
    Details
    ISSN: 1432-0851
    Keywords: Key words Radioimmunodetection ; Radioimmunotherapy ; Monoclonal antibody ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The study was designed to clarify the difference in pharmacokinetics of monoclonal antibodies (mAb) in animal models and humans, and to elucidate the applicability of animal models. 99mTc-labeled murine mAb – against carcinoembryonic antigen (designated BW431/26), and neural cell adhesion molecule (NE150) – and one chimeric mouse/human mAb against nonspecific cross-reacting antigen (chNCA) were administered i.v. to normal mice and athymic mice (370 kBq, 400 ng) xenografted with human cancer cells expressing antigens, and into patients with tumor (925 MBq, 1 mg). The biodistribution of two of the three mAb (not 99mTc-BW431/26) differed clearly in mice and patients. 99mTc-NE150 showed specific uptake in xenografted tumor and otherwise a normal biodistribution; however, clinical examination showed increased uptake in the liver with rapid blood clearance (mean α half-life = 31.1 min) compared with 99mTc-BW431/26 (28.4 h). 99mTc-chNCA demonstrated increased blood clearance and renal excretion in both normal and athymic mice, with accumulation in tumors. Clinical examination showed rapid blood clearance (mean α half-life = 6.4 min) and increased uptake in the liver. High-performance liquid chromatographic analysis of 99mTc-chNCA revealed the immune complex in blood, suggesting uptake of the complex by the reticuloendothelial cells. The biodistribution of radiolabeled mAb in animal and human models was variable and specific for each of the three mAb. The results of animal studies with mAb should be evaluated carefully before being extrapolated to humans, on the basis of the nature of the mAb and interacting substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050492
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