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  • 1
    Electronic Resource
    Electronic Resource
    The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease (1998)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 159 (1998), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The purpose of this work was to identify the function of an open reading frame called YBL042, found during the systematic sequencing of Saccharomyces cerevisiae's chromosome II. The YBL042 gene product shows 70% similarity with the uracil permease and the allantoin permease encoded by FUR4 and DAL4, respectively. The mutation constructed by disruption of this ORF is allelic to the FUI1 gene previously described as encoding the uridine permease but not cloned yet. A strain carrying the disrupted allele and a fui1 mutant exhibit the same phenotype as they do not grow on a medium containing uridine as the sole source of pyrimidines and as they are resistant to 10−3 M 5-fluorouridine (5FUI), a toxic analog of uridine. Even though the FUI1 gene has a multicopy suppressor effect on uracil transport, its product does not seem to be involved in this transport, in contrast to the FUR4 gene product which is involved in uridine transport. Moreover, the FUI1 gene product does not play any role in allantoin transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1998.tb12843.x
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  • 2
    Electronic Resource
    Electronic Resource
    Eine ophthalmologische Bilddatenbank im Internet (1998)
    Springer
    Der Ophthalmologe 95 (1998), S. 507-510 
    Details
    ISSN: 1433-0423
    Keywords: Key words Internet - Ophthalmological information ; Schlüsselwörter Internet ; Ophthalmologische Informationen ; Bildatlas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Durch das steigende Informationsangebot und einen relativ leichten Einstieg finden immer mehr Ophthalmologen Zugang zum Internet. Ein jederzeit und jederorts abrufbarer ophthalmologischer Befundbildatlas mit zugehörigem ICD-Schlüssel im World Wide Web bietet verschiedene Möglichkeiten, wie z.B. Aufruf eines typischen Befundbildes zum differentialdiagnostischen Vergleich, zur eigenen Weiterbildung oder Verwendung für den eigenen Bedarf (u.a. Präsentationen). Bis jetzt wurden bereits über 500 typische Befundbilder ausgewählt, digitalisiert und in eine Datenbank integriert, die über 4700 ICD-standardisierte und -codierte Diagnosen enthält. Bildbezogene Diagnosen und die Bilder werden mit dieser Datenbank verknüpft. Nach Eingabe eines diagnostischen Suchbegriffs bewirken spezielle Programmskripte die Datenbanksuche und die Ausgabe der Suchergebnisse in automatisch erstellten Web-Seiten. Die gefundenen Bilder werden zur Minimierung des Datentransfers zunächst in Kleinformat (Thumbnails) ausgegeben und sind auf Mausklick im Vollformat zu erhalten. Neben Diagnose und ICD-Schlüssel-Nummer werden zu jedem Bild der Autor, ein diagnostischer Hinweis (Hausdiagnose) und ein Kommentar bzw. Kommentarmöglichkeit angeboten. Der von uns entwickelte Gießener Ophthalmologische Bildatlas ist unter der Internetadresse www.med.uni-giessen.de [Überlokale Infosysteme] abrufbar. Er ermöglicht einen gezielten, raschen und kostenlosen Diagnose- und Befundbildabruf mit zugehörigem ICD-Schlüssel und stellt eine sinnvolle Ergänzung zum Studium von gedruckten ophthalmologischen Bildatlanten dar.
    Notes: The Internet has become a powerful, international source for information, and it has shown an exponential growth because of the ease of access and the immediate availability of information. We introduced a new ophthalmological atlas including ICD coding on the World Wide Web. So far, more than 500 lantern slides of typical and interesting ophthalmological findings have been selected and digitized. These pictures were integrated in a data base, which was arranged for ease and speed of search and retrieval. In its background, the data base contains a list of over 4700 ICD-encoded diagnoses to which the picture-documented findings are linked. Comments on pictures can be added by the author or by users. The data base contains several lists, such as a list of ICD codes and diagnoses, a list of all pictures with corresponding diagnoses, a list of all diagnoses and number of picture, a list of those diagnoses for which the corresponding picture is available, as well as a list of comments on each picture. Special program scripts handle the user's search key words for diagnoses and extract the required information out of the data base, using Windows NT. Search results are presented on an automatically built-up webpage. To provide fast speed of search all pictures initially are shown in a small format (thumbnails) with little amount of data. The related full-size picture is retrieved by a single mouse click. Moreover, the name and institution of the author, diagnostical hints and comments on pictures by the author or by users are offered for each diagnosis available. The Giessen Ophthalmological Picture Atlas can be reached under www.med.uni-giessen.de in the Internet. It allows a fast search free of charge from all over the world and, therefore, offers an additional option to obtain specific ophthalmological information for various purposes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003470050307
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  • 3
    Electronic Resource
    Electronic Resource
    Solution for extraarticular hip fractures using the “sliding-screw-nail”-principle. Results of two different systems (classic nail and gamma nail) (1998)
    Springer
    Der Unfallchirurg 101 (1998), S. 894-900 
    Details
    ISSN: 1433-044X
    Keywords: Key words Peritrochanteric fracture • Gamma nail • Classic nail • Intramedullary hip screw • Sliding-screw nail implant ; Schlüsselwörter Fraktur koxales Femurende •γ -Nagel • IMHS • Gleitschrauben-Nagel-Implantat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen Januar 1993 und Dezember 1995 haben wir bei 109 Patienten (Altersmedian 75 Jahre) insgesamt 112 extraartikuläre Frakturen des proximalen Femurendes einschließlich Kombinationsfrakturen Schaft – Trochanterregion in Serie mit unterschiedlichen „Gleitschrauben-Nagel-Implantaten“ [61 classic nail (IMHS), 51 γ -Nägel (GN)] versorgt. Beim Systemvergleich zeigten beide Implantatvarianten im Detail Vor- und Nachteile, erwiesen sich jedoch prinzipiell als gleichwertig. Komplikationen in Form von sekundärer Schenkelhalsvarisierung mit „cut-out“ (1,8 %) und ohne „cut-out“ (1,8 %) der Gleitschraube, 2 intraoperativ erzeugten und konservativ behandelten Schaftfissuren (1,8 %), einer Nagelperforation des Femur (0,9 %) sowie 3 Infekten (2,7 %) machten insgesamt 5 Reoperationen (4,5 %) nötig, wobei keine dieser Komplikationen dem Prinzip selbst oder den Implantatvarianten anzulasten ist. Alle Patienten wurden mindestens bis zum Ende des 1. postoperativen Jahres weiterverfolgt, 59 % der Patienten erreichten ihre Ausgangsmobilität wieder. IMHS und GN sind ausgezeichnete und gleichwertige Implantate, die den biomechanischen Anforderungen der obengenannten Frakturformen genügen.
    Notes: Summary Between January 1993 and December 1995 we treated 109 patients (median age: 75 years) with 112 extraarticular hip fractures including combined trochanteric and shaft fractures using two different “sliding-screw-nail implants” (intramedullary hip screw = classic nail: n = 61; gamma nail: n = 51). Comparing the two systems in detail certain advantages and disadvantages were seen, with both being equivalent. We encountered the following complications: secondary varus malalignment of the collum femoris with “cut out” of the sliding-screw (1.8 %) and without “cut out” (1.8 %), fissure of the femoral shaft occuring intraoperatively and being treated conservatively (1.8 %), femoral perforation by the nail (0.9 %), infection (2.7 %). Thus, 5 reoperations (4.5 %) were necessary. None of these complications were attributable to the principle itself or to the different implants used. Each patient was followed-up for a minimum of 12 months postoperatively. In 59 % of all patients the pre-trauma range of mobility could be fully restored. Intramedullary hip screw and gamma nail are excellent and equivalent systems, which fully satisfy the biomechanical needs of above mentioned fractures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001130050355
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  • 4
    Electronic Resource
    Electronic Resource
    Taking the wrong drugs: the role of substance abuse and medication noncompliance in violence among severely mentally ill individuals (1998)
    Springer
    Social psychiatry and psychiatric epidemiology 33 (1998), S. S75 
    Details
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Increasing numbers of severely mentally ill individuals are being treated in nonhospital, community-based settings and public concern about potential violence by these individuals has increased, often as a result of tragic, albeit uncommon events. The present study examines potential predictors of serious violence among persons with severe mental illness (SMI), with a specific focus on the joint effect of substance abuse and medication noncompliance. Subjects in the study are involuntarily admitted inpatients with SMI awaiting a period of court-ordered outpatient treatment, termed “involuntary outpatient commitment”. During enrollment in a longitudinal outcome study of the effectiveness of OPC, 331 subjects and, whenever feasible, family members or other informants were interviewed. In addition, complementary data were gathered by review of involuntary commitment records and hospital records. Data collection included sociodemographic characteristics, illness history, clinical status, medication adherence, substance abuse and violent behavior during the 4 months preceding hospitalization. Descriptive and multivariable logistic regression procedures were used to examine the association between serious violent acts and a number of personal, social, and clinical characteristics. The combination of medication noncompliance and substance abuse was a significant predictor of serious violent acts in the community. Individuals who had problems with both alcohol and illicit drug abuse appear to be at greatest risk for violence. These results suggest that reducing violence risk among persons with SMI requires an aggressive approach to improving medication adherence in the context of integrated mental health and substance abuse treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001270050213
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  • 5
    Electronic Resource
    Electronic Resource
    Psychiatric impairment, social contact, and violent behavior: evidence from a study of outpatient-committed persons with severe mental disorder (1998)
    Springer
    Social psychiatry and psychiatric epidemiology 33 (1998), S. S86 
    Details
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The need to better understand and manage risk of violent behavior among people with severe mental illness in community care settings is increasingly being recognized, as public-sector mental health systems face mandates to provide more cost-effective services in less restrictive environments. The potential for serious violence in a small proportion of severely mentally ill (SMI) individuals has emerged as a key factor that increases cost and limits continuity and normalization of community-based services for populations with psychiatric disabilities. A major challenge to developing better strategies for risk assessment and management in community care settings involves specifying complex interactions between psychiatric impairment and the conditions of social life – including the quality and frequency of contact with others at close quarters. This is a study of the determinants of violent behavior in a sample of 331 adults with severe mental disorders in community-based treatment. An interaction between severity of functional impairment and frequency of social contact was found to be significantly associated with risk of violence. Among respondents with Global Assessment of Functioning (GAF) scores in the lowest 20%, more frequent contact with family and friends was linked to a higher probability of violent events. However, among better functioning respondents, frequent social contact was associated with lower risk of violence and greater satisfaction with relationships. These findings suggest that, where violence risk is concerned, the most salient feature of psychiatric impairment is the impairment of social relationships –the ways in which disorders of thought and mood not only distort one's subjective appraisal of experience and threat, but impair the ability to relate meaningfully to others, to resolve conflict and derive necessary support from family and friends. Thus, social contact may be a mixed blessing for SMI individuals. For some, it signals a positive quality of life, but for others – particularly those with extreme psychiatric impairment – frequent contact may add to conflict, stress, and increased potential and opportunity for physical violence. The impact of psychiatric impairment on violent behavior cannot be known in isolation, but must be considered in a social context. Effective community-based strategies to anticipate and prevent violence in the lives of persons with severe mental illness must take into account such interactions between social and clinical variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001270050215
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  • 6
    Electronic Resource
    Electronic Resource
    The uracil permease of Schizosaccharomyces pombe: A representative of a family of 10 transmembrane helix transporter proteins of yeasts (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 14 (1998), S. 1051-1059 
    Details
    ISSN: 0749-503X
    Keywords: Schizosaccharomyces pombe ; Saccharomyces cerevisiae ; uracil permease ; transmembrane helices ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The uracil permease gene of Schizosaccharomyces pombe was cloned and sequenced. The deduced protein sequence shares strong similarities with five open reading frames from Saccharomyces cerevisiae, namely the uracil permease encoded by the FUR4 gene, the allantoin permease encoded by DAL4, a putative uridine permease (YBL042C) and two unknown ORFs YOR071c and YLR237w.A topological model retaining ten transmembrane helices, based on predictions and on experimental data established for the uracil permease of S. cerevisiae by Galan and coworkers (1996), is discussed for the four closest proteins of this family of transporters. The sequence of the uracil permease gene of S. pombe has been deposited in the EMBL data bank under Accession Number X98696. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Silicon-modified carbohydrate surfactants IX: dynamic wetting of a perfluorinated solid surface by solutions of a siloxane surfactant above and below the critical micelle concentration (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 12 (1998), S. 843-853 
    Details
    ISSN: 0268-2605
    Keywords: carbohydrate-modified phenylsiloxane ; surfactants ; wetting behaviour ; superspreading ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The dynamic wetting behaviour on a perfluorinated, low-energy solid has been investigated for a carbohydrate-modified phenylsiloxane surfactant. The surfactant concentration, the rate of interface generation and the [solid/liquid interface area] : [liquid/vapour interface area] ratio were varied systematically. Dynamic data for the liquid/vapour (γlv) and solid/liquid (γsl) interfacial tension as well as their Lifshitz-van der Waals and donor-acceptor contributions were determined under strictly controlled conditions. Since γsl reacts sensitively to variations of the surfactant concentration and the rate of interface generation, the covering of the liquid/non-polar solid interface is assumed to be a spreading limiting factor. The corresponding γlv values remain constant and close to those obtained under equilibrium conditions. Copyright © 1998 John Wiley & Sons, Ltd.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Silicon-modified carbohydrate surfactants VI: Synthesis of carbosilane, silane, polysilane and non-permethylated siloxane derivatives; the wetting behaviour of epoxy-modified precursor liquids on non-polar surfacesIn remembrance of Professor Dr Edwin Hengge (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 12 (1998), S. 47-58 
    Details
    ISSN: 0268-2605
    Keywords: surfactants ; carbohydrate ; carbosilane ; silane ; wetting ; surface tension ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis of carbohydrate surfactants bearing carbosilane, silane, polysilane and non-permethylated siloxane moieties is described. These surfactants consist of three structural elements: (1) a silicon-containing moiety, (2) a spacer and (3) a carbohydrate unit. Additionally two different types of mixed structures have been synthesized: (a) single-chained carbosilane-siloxane surfactants and (b) double-chained combinations of carbo- silanes, silanes and siloxanes. The wetting behaviour of the key intermediates, the allyl glycidyl derivatives, has been investigated by static surface tension (γlv, σ) and wetting tension (γsv-γsl, α) measurements on a non-polar perfluorinated surface (FEP® plate). The contact angles obtained for these pure liquids are not a linear function of the surface tension but depend on the polarity of the substructures. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Silicon-modified carbohydrate surfactants. VII: Impact of different silicon substructures on the wetting behaviour of carbohydrate surfactants on low-energy surfaces  -  distance decay of donor-acceptor forces (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 12 (1998), S. 265-276 
    Details
    ISSN: 0268-2605
    Keywords: carbohydrate surfactants ; wetting behaviour ; siloxane ; silane ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The wetting behaviour of carbohydrate surfactants bearing siloxane, carbosilane, polysilane or silane moieties has been investigated. By static surface tension (γlv, σ) and wetting tension (γsv-γsl, α) measurements on a non-polar perfluorinated surface (FEP®), the contact angles of aqueous surfactant solutions above the critical micelle formation concentration (cmc) were determined. Surface tension and wetting tension react independently on defined changes in the chemical structure of the surfactant molecules. Siloxane surfactants reduce the surface tension most effectively, whereas for a neopentyl-substituted silane derivative the lowest solid/liquid interfacial tension was found. The data for isomeric siloxanes, carbosilanes and silanes suggest that donor-acceptor forces at solid interfaces have a maximum range of about 4.5 Å. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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