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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 14 (1998), S. 0 
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Following the successful treatment of infectious fish diseases using dimerized lysozyme (KLP-602), its influence on the nonspecific cellular and humoral defence mechanisms and protection against viral diseases in rainbow trout (Oncorhynchus mykiss) was evaluated. KLP-602 was applied in diets, at a dose of 10 μg kg-1 body weight, for a period of 7 days. One week after feeding with the diets containing KLP-602, the immunomodulatory effects on the suppressed cellular and humoral defence mechanisms were observed in fish naturally infected by infectious pancreatic necrosis virus (IPNV). All immunological parameters were significantly increased in comparison with untreated fish. Cumulative mortality was lower in fish fed the dietary treatment containing dimerized lysozyme (30%), compared with untreated fish (65%). The results showed that the lysozyme dimer (KLP-602) modulated the cellular and humoral defence mechanisms after suppression induced by IPNV.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 22 (1998), S. 235-249 
    ISSN: 1432-0541
    Keywords: Key words. Dynamic algorithm, Graph algorithm, Shortest path, Minimum-cost path, Planar graph.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. In this paper we give a fully dynamic approximation scheme for maintaining all-pairs shortest paths in planar networks. Given an error parameter $\epsilon$ such that $0〈\epsilon$ , our algorithm maintains approximate all-pairs shortest paths in an undirected planar graph G with nonnegative edge lengths. The approximate paths are guaranteed to be accurate to within a 1+ $\epsilon$ factor. The time bounds for both query and update for our algorithm is O( \epsilon -1 n 2/3 log 2 n log D) , where n is the number of nodes in G and D is the sum of its edge lengths. The time bound for the queries is worst case, while that for the additions is amortized. Our approximation algorithm is based upon a novel technique for approximately representing all-pairs shortest paths among a selected subset of the nodes by a sparse substitute graph.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 383 (1998), S. 71-74 
    ISSN: 1435-2451
    Keywords: Key words Surgical risk ; Cytokines ; Acute-phase response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background/aims: In some patients postoperative infective complications are related to a reduced resistance to the operative trauma and the perioperative microbiological challenge. To investigate preoperative alterations in the immune responses in patients who had mounted an acute-phase response before the operation, we measured the capacity of tumor necrosis factor α and interleukin-6 production in whole blood. Patients/methods: Serum concentrations of C-reactive protein, α 1-antitrypsin, albumin, and prealbumin were measured in 89 patients submitted for major abdominal surgery on their admission to hospital. Results: In 23 patients (26%) we found concentrations of at least one, and in 16 patients (18%) of two or more of these variables beyond the reference range. Patients who mounted an acute-phase response released 37% less TNFα (1339 vs. 848 pg/ml) and 31% less IL-6 (24 293 vs. 16 900 pg/ml) when whole blood was stimulated with lipopolysaccharide 0.5 µg/ml. Conclusion: Patients who mount an acute-phase response before operation may thus have a downregulated immune response at the level of proinflammatory cytokines. This is likely to alter their resistance to invasive micro-organisms in the perioperative period.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 93 (1998), S. s001 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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