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  • 1995-1999  (2)
  • 1998  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Controlled Radiofrequency Endotubal Sterilization (1998)
    Springer
    Advances in contraception 14 (1998), S. 147-152 
    Details
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Study objective: A safe, effective, inexpensive method of transcervical tubal sterilization could have a major impact on women's health. In this study, we evaluated the efficacy of a new radiofrequency catheter prototype designed for endotubal sterilization using animal models. Setting: Animal research laboratory. Design: Prospective observational study. Method: The optimal energy delivery to create a complete circumferential transmural thermal lesion in the tube was determined in 114 in vitro acute studies using porcine and bovine fallopian tubes. A study was then initiated with eight mini-pigs. Thirty-four lesions were made in the fallopian tubes using computer-controlled power delivery. Three weeks later the animals were euthanized and evaluated. Measurements and main results: A hydrosalpinx was evident in 8/11 of the tubes with separate proximal and distal cautery, implying occlusion at each of these sites. Complete occlusion of the tubes was seen at 12/22 sites evaluated by histology. Narrowing was seen in 9/22, and 1/22 was open. Conclusion: The endotubal cautery prototype creates a reproducible lesion, but did not always cause complete closure of the tube in this preliminary study. However, based on our results, we hypothesize that a radiofrequency catheter can be developed for minimally invasive transcervical sterilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006542801632
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of tumour depth, blood absorption and autofluorescence on measurements of exogenous fluorophores in tissue (1998)
    Springer
    Lasers in medical science 13 (1998), S. 22-31 
    Details
    ISSN: 1435-604X
    Keywords: Carothenoporphyrin ; Fluorescence ratio ; Fluorescence spectroscopy ; Tissue optics ; Tumour detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract We investigated the influence of tumour depth and differences in blood concentration and autofluorescence between tumour and normal tissue on the fluorescence of a tumour-localising agent. Carotenoporphyrin, CP(Me)3, was injected into rats and nude mice with intradermal tumours. On the tumours an incision was made, uncovering 2 mm2 of the tumour, and fluorescence measurements, including excitation-emission maps and fluorescence ratios, were made on skin, covered and uncovered tumour. The measured fluorescence ratio in the uncovered tumour showed a three- to tenfold increase compared to the covered tumour. We used a one-dimensional layered tissue model to analyse the data. In conclusion, even with a high tumour-selectivity deeper lying tumours cannot always be detected, particularly if the tumour has a high blood concentration or low autofluorescence intensity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592957
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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