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  • 1995-1999  (4)
  • 1999  (4)
  • Phenotype  (1)
  • Rat (Wistar)  (1)
  • ULTRASTRUCTURE  (1)
  • depression  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Phenotype ; t(8;21)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (–), CD33(–), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of clinical psychiatry 11 (1999), S. 109-112 
    ISSN: 1573-3238
    Keywords: old age ; service delivery ; outcome ; depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Psychogeriatrics and especially psychiatric services in nursing and old-age homes are sorely lacking in research. Four years ago we developed and implemented a model for service delivery for old-age homes within our hospitals' catchment area. In the first year of operation 48 of 373 residents (13%) were evaluated and treated by a psychogeriatrician. The aim of the present study was to evaluate outcome of these patients three years later. All patients and medical records were re-assessed. During the three-year period 16/48 subjects (33.3%) passed away; of these half were previously diagnosed as suffering from a major depressive episode. None of the subjects who died had attempted suicide. Following a preliminary diagnosis of affective spectrum disorder, 4/48 patients (8.3%) were re-diagnosed at follow up as suffering from dementia. Full or partial remission of the original symptomatology was achieved in 18/32 surviving subjects (50.7%); mostly depressed or anxious patients. We conclude that although mortality rate among elderly psychiatric patients is high persistent interventions lead to successful remission in the majority of patients.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0878
    Keywords: Key words Thyroid gland ; Calcitonin ; C-cell hyperplasia ; C-cell carcinoma ; Medullary thyroid carcinoma ; Sexual dimorphism ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  In many rat strains, C-cell hyperplasia occurs in an age-dependent manner and is often associated with multifocal C-cell carcinoma. The purpose of this study was to investigate the spectrum of spontaneous, proliferative C-cell disorders by gender in Wistar rats throughout their lifespan. The incidence of C-cell hyperplasia shows a significant increase with age (P〈0.001) and is much higher in female rats than in male rats (P〈0.05). From 3 to 24 months of life, 27.5% of female rats showed a normal C-cell pattern, 55.0% showed C-cell hyperplasia, and 17.5% showed C-cell tumors; while 57.5% of male rats showed a normal C-cell pattern, 32.5% showed C-cell hyperplasia, and 10% showed C-cell tumors. Although the overall frequency of C-cell neoplasms in females was nearly double that in males, these data are not statistically significant. However, the number of C-cell tumors showed a significant increase with age (P〈0.05). Therefore, we can conclude that there were significant differences in the incidence of the total spectrum of C-cell proliferative abnormalities in the thyroid gland of Wistar rats that were both age-dependent and gender-dependent.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2568
    Keywords: INFLAMMATORY BOWEL DISEASE ; TRINITROBENZENESULFONIC ACID ; HISTOLOGY ; ULTRASTRUCTURE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammatory bowel disease (IBD) of humans is achronic and devastating disease of unknown etiology.Models of acute colitis in animals have been achieved byintrarectal administration of agents such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) intorat colon. This agent induces focal inflammation andalterations in the colon with features similar to thosefound in chronic inflammatory diseases in humans. The aim of this study was to assess the effectof TNBS administration on histological andultrastructural features of the rat colon, especially inareas not affected by transmural inflammation. Also in areas without transmural inflammation, weobserved a significant increase in crypt diameter and inthe number and area of the goblet cells, as well asalterations in the contents of mucin in goblet cells. We conclude that TNBS treatment in rats led tosevere changes in normal architecture of the colon andalso in damaged areas where no direct inflammation wasproduced.
    Type of Medium: Electronic Resource
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