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  • 1
    Electronic Resource
    Electronic Resource
    Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (–), CD14 (–), and CD33 (–) (1999)
    Springer
    Annals of hematology 78 (1999), S. 237-240 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Phenotype ; t(8;21)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (–), CD33(–), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050508
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Correlation between gender and spontaneous C-cell tumors in the thyroid gland of the Wistar rat (1999)
    Springer
    Cell & tissue research 297 (1999), S. 451-457 
    Details
    ISSN: 1432-0878
    Keywords: Key words Thyroid gland ; Calcitonin ; C-cell hyperplasia ; C-cell carcinoma ; Medullary thyroid carcinoma ; Sexual dimorphism ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  In many rat strains, C-cell hyperplasia occurs in an age-dependent manner and is often associated with multifocal C-cell carcinoma. The purpose of this study was to investigate the spectrum of spontaneous, proliferative C-cell disorders by gender in Wistar rats throughout their lifespan. The incidence of C-cell hyperplasia shows a significant increase with age (P〈0.001) and is much higher in female rats than in male rats (P〈0.05). From 3 to 24 months of life, 27.5% of female rats showed a normal C-cell pattern, 55.0% showed C-cell hyperplasia, and 17.5% showed C-cell tumors; while 57.5% of male rats showed a normal C-cell pattern, 32.5% showed C-cell hyperplasia, and 10% showed C-cell tumors. Although the overall frequency of C-cell neoplasms in females was nearly double that in males, these data are not statistically significant. However, the number of C-cell tumors showed a significant increase with age (P〈0.05). Therefore, we can conclude that there were significant differences in the incidence of the total spectrum of C-cell proliferative abnormalities in the thyroid gland of Wistar rats that were both age-dependent and gender-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410051371
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental Colitis Induced by Trinitrobenzenesulfonic Acid (An Ultrastructural and Histochemical Study) (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 2523-2529 
    Details
    ISSN: 1573-2568
    Keywords: INFLAMMATORY BOWEL DISEASE ; TRINITROBENZENESULFONIC ACID ; HISTOLOGY ; ULTRASTRUCTURE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammatory bowel disease (IBD) of humans is achronic and devastating disease of unknown etiology.Models of acute colitis in animals have been achieved byintrarectal administration of agents such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) intorat colon. This agent induces focal inflammation andalterations in the colon with features similar to thosefound in chronic inflammatory diseases in humans. The aim of this study was to assess the effectof TNBS administration on histological andultrastructural features of the rat colon, especially inareas not affected by transmural inflammation. Also in areas without transmural inflammation, weobserved a significant increase in crypt diameter and inthe number and area of the goblet cells, as well asalterations in the contents of mucin in goblet cells. We conclude that TNBS treatment in rats led tosevere changes in normal architecture of the colon andalso in damaged areas where no direct inflammation wasproduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026651408998
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    Paper (German National Licenses)
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