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  • 1
    Electronic Resource
    Electronic Resource
    A major metabolite of aceclofenac, 4′-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells (2000)
    Springer
    Inflammation research 49 (2000), S. 133-138 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Aceclofenac — 4′-Hydroxy aceclofenac — Pro-matrix metalloproteinase 1 — Pro-matrix metalloproteinase 3 — Rheumatoid synovial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We examined the effects of aceclofenac and its metabolites on the production of pro-collagenase-1/pro-matrix metalloproteinase-1 (proMMP-1), pro-gelatinase A/proMMP-2, pro-stromelysin-1/proMMP-3 and tissue inhibitor of metalloproteinases-1 (TIMP-1) by rheumatoid synovial cells.¶Materials: Synovial cells were obtained from patients with rheumatoid arthritis.¶Treatment: Cultures of confluent cells were treated with interleukin-1β (IL-1β)(1 ng/ml) and/or test drugs (0.3-30 μM) for 48 h.¶Methods: Production of proMMPs and TIMP-1 was monitored by Western blotting or gelatin zymography. Prostaglandin E2 (PGE2) was measured by an enzyme immunoassay.¶Results: 4′-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1β-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.¶Conclusions: Down-regulation of proMMP-1 and proMMP-3 production by 4′-hydroxy aceclofenac may contribute to the therapeutic effect of aceclofenac on rheumatoid arthritis and osteoarthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050571
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of nonionic emulsifier on the production of multihollow polymer particles by the stepwise acid/alkali method (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 358-363 
    Details
    ISSN: 1435-1536
    Keywords: Key words Hollow ; Particle ; Emulsion polymerization ; Morphology ; Swelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effects of nonionic emulsifier on the formation of multihollow structures formed within sub-micron-sized polymer particles by the “acid/alkali method” proposed by the authors were examined. The original acid-swellable particles were produced by seeded emulsion terpolymerization of styrene, butyl acrylate, and dimethylaminoethyl methacrylate. The results indicate that the nonionic emulsifier had a great effect on the formation of multihollow particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050525
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Spin glass behavior probed by various methods with different time- and space-scale of observation: Ising spin glass Fe0.50Mn0.50TiO3 (2000)
    Springer
    Hyperfine interactions 126 (2000), S. 287-297 
    Details
    ISSN: 1572-9540
    Keywords: Fe0.50Mn0.50TiO3 ; spin glass ; Ising character ; AT-line ; time- and space-scale of observations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Under the expectation that the behavior of a spin glass (SG) system shows various aspects depending on the time- and space-scale of observations, we have studied the typical Ising spin glass Fe0.50Mn0.50TiO3 by measuring dc-magnetization, ac-susceptibility, Mössbauer spectrum, neutron scattering intensity and μ+SR time spectrum. We have demonstrated that the application of various methods with different time- and space-scale of observations to the same system is useful to clarify the property of the spin glass freezing, the Ising character and the de Almeida and Thouless-line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012635115498
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  • 4
    Electronic Resource
    Electronic Resource
    Preferential Spin Orientation of Fe2+ Towards the c-Axis in FexNi1-xCl2 System (0.034, 0.068 and 0.079) (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 246 (2000), S. 101-106 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Fe x Ni1-x Cl2 is a mixed metal chloride and a random mixture with competing orthogonal spin anisotropies. In pure systems, Fe2+ shows a preferential spin inclination to the c-axis, while Ni2+ shows a weak spin anisotropy in the c-plane. Mössbauer spectra of the Fe x Ni1-x Cl2 system (0.034〈x〈0.079) observed below the Néel temperature (T N ) are composed of two types of sub-spectra: spectra I and II. We report the Mössbauer study of the magnetic behavior of different types of Fe2+ spins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006737201131
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    Paper (German National Licenses)
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