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  • 1
    Electronic Resource
    Electronic Resource
    A major metabolite of aceclofenac, 4′-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells (2000)
    Springer
    Inflammation research 49 (2000), S. 133-138 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Aceclofenac — 4′-Hydroxy aceclofenac — Pro-matrix metalloproteinase 1 — Pro-matrix metalloproteinase 3 — Rheumatoid synovial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We examined the effects of aceclofenac and its metabolites on the production of pro-collagenase-1/pro-matrix metalloproteinase-1 (proMMP-1), pro-gelatinase A/proMMP-2, pro-stromelysin-1/proMMP-3 and tissue inhibitor of metalloproteinases-1 (TIMP-1) by rheumatoid synovial cells.¶Materials: Synovial cells were obtained from patients with rheumatoid arthritis.¶Treatment: Cultures of confluent cells were treated with interleukin-1β (IL-1β)(1 ng/ml) and/or test drugs (0.3-30 μM) for 48 h.¶Methods: Production of proMMPs and TIMP-1 was monitored by Western blotting or gelatin zymography. Prostaglandin E2 (PGE2) was measured by an enzyme immunoassay.¶Results: 4′-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1β-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.¶Conclusions: Down-regulation of proMMP-1 and proMMP-3 production by 4′-hydroxy aceclofenac may contribute to the therapeutic effect of aceclofenac on rheumatoid arthritis and osteoarthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050571
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice (1998)
    Springer
    Inflammation research 47 (1998), S. 182-186 
    Details
    ISSN: 1420-908X
    Keywords: Key words: YPE-01 — Diarylheptanoid — 5-Lipoxygenase — Leukotriene — Ear edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We investigated the anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative in vitro and in vivo.¶Material: In the in vitro study, rat basophilic leukemia (RBL-1) cells were used. For the in vivo study, ICR and ddY mice (male, 7 weeks old) were used.¶Treatment: In the in vitro study, the supernatant of RBL-1 cells lysate was incubated with 50 μM arachidonic acid (AA) and 0.01-100 μM test drugs for 15 min. RBL-1 cells were preincubated with 0.01–100 μM test drugs for 10 min before incubation with 0.5 μM calcium ionophore A23187 for 10 min. In the in vivo study, YPE-01 (0.1–3 mg/ear) was applied to the ear of mice at the same time as a 12-O-tetradecanoylphorbol 13-acetate (TPA) application or 1 h before an AA application.¶Methods: In the in vitro study, the amounts of 5-hydroxyeicosatetraenoic acid and leukotrienes were measured by high-performance liquid chromatography and an enzyme immunoassay, respectively. In the in vivo study, a circular tissue sample from the ear of the mice was weighed. Statistical analysis was done using Dunnett's test.¶Results: YPE-01 inhibited the 5-lipoxygenase activity (IC50, 0.28 μM) and the leukotriene B4 (IC50, 0.035 μM) and C4 (IC50, 0.046 μM) production by RBL-1 cells without any inhibition of cyclooxygenase activity in vitro. The topical application of YPE-01 significantly suppressed both the AA- and TPA-induced ear edemas in vivo.¶Conclusions: YPE-01 is a selective 5-lipoxygenase inhibitor with a suppressive effect against dermal inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050315
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of antitumor activity ofLactobacillus casei with other bacterial immunopotentiators (1984)
    Springer
    Medical microbiology and immunology 173 (1984), S. 113-125 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antitumor activity ofLactobacillus casei YIT 9018 (LC9018) was demonstrated by intralesional (i. 1.) or intravenous (i. v.) administration into tumor-bearing mice which were inoculated with methylcholanthrene-induced fibrosarcoma (Meth A) or Kirsten murine sarcoma virus-transformed tumor (K234) cells. Its activity was significantly superior to the activity of two other species of lactobacilli but was nearly the same as that ofCorynebacterium parvum orMycobacterium bovis Bacille Calmette-Guérin (BCG). I. l. or i. v. administration of LC9018 into the tumor bearers caused local transient swelling or hepatosplenomegaly but did not cause other pronounced lesions. There was no significant difference in the degree of hepatosplenomegaly in LC9018 and that in other immunopotentiators. In mice whose tumors had regressed as a result of administration of LC9018 or the other immunopotentiators, the phytohemagglutinin P (PHA-P) response of the spleen cells was less than that of mice whose tumors progressed, and approached the normal level. The PHA-P response of popliteal lymph node cells proximal to the tumor lesion was fairly low compared with the splenic PHA-P response and there was no difference between the lymphocytes from mice whose tumors had regressed or progressed. Adjuvant activity of LC9018 in inducing tumor immunity was demonstrated by administering a mixture of LC9018 and Meth A cells to mice. This adjuvant activity was of the same efficiency as that ofC. parvum and BCG. The presence of the antitumor activity of LC9018 in cell wall components was deduced from fact that removal of its cell wall by endo-N-acetylmuramidase (M-1 enzyme) abolished the activity. The possible availability of LC9018 for immunotherapy of tumors is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123760
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  • 4
    Electronic Resource
    Electronic Resource
    Augmentation of antimetastatic effect on Lewis lung carcinoma (3LL) in C57BL/6 mice by priming with Lactobacillus casei (1990)
    Springer
    Medical microbiology and immunology 179 (1990), S. 161-168 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The augmentation of the antimetastatic effect of heat-killed cells of Lactobacillus casei YIT9018 (LC 9018) on Lewis lung carcinoma (3LL) in C57BL/6 mice by presensitization (priming) with LC 9018 was examined. Intralesional injection of LC 9018 into 3LL-bearing mice inhibited both the growth of the primary tumors and the formation of lung metastases, and this effect was significantly augmented by subcutaneous injection of LC 9018 before the tumor inoculation. In the LC 9018-primed mice, intraperitoneal administration of LC 9018 into syngeneic hosts after priming induced a high level of interleukin-2 (IL-2) and interferon-γ (IFN-γ) in the peritoneal cavity. At this time, T cells of the spleen cells from the LC 9018-primed mice proliferated and produced IL-2 when co-cultured with LC 9018 as antigen in vitro. Also, the phenotype of these T cells was found to be L3T4+ and Ly-2.2− T cells by analysis by flow cytometry. These results suggest that LC 9018-reactive helper T (Th) cells were induced by the priming and subsequent challenge with LC 9018, and that IL-2 or IFN-γ, which was produced by the activated LC 9018-reactive Th cells, augmented a host immune response resulting the antitumor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202393
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of age and dietary composition on aortic collagen to elastin ratio and on lipid metabolism in F-344 rat
    Amsterdam : Elsevier
    Experimental Gerontology 16 (1981), S. 35-39 
    Details
    ISSN: 0531-5565
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0531-5565(81)90006-1
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  • 6
    Electronic Resource
    Electronic Resource
    The Role of Superoxide Anion and Lysosomal Enzymes in Anti-Listerial Activity of Elicited Peritoneal Macrophages (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of Listeria monocytogenes EGD (listeria) by peritoneal macrophages (PM) was investigated. Generation of superoxide anion by PM stimulated with phorbol myristate acetate (PMA) was significantly increased by intraperitoneal injection of Lactobacillus casei YIT 9018 (LC9018) or Corvnebacterium parvum (CP), but not by injection of peptone. However, superoxide anion generation by LC9018-elicited PM stimulated with listeria was not increased any more than that by peptone-elicited PM. and generation of superoxide anion by the PM was affected by the difference in stimuli. The killing of listeria by LC9018- or CP-elicited PM in vitro was significantly less than that by peptone-elicited PM or resident PM, Significant correlation was observed between the anti-listerial activity of PM and the intracellular killing of listeria by PM. On the other hand γ-glucuronidase and γ-N-acetyl-D-glucosaminidase activities of LC9018-elicited, CP-elicited, or resident PM were significantly weaker than those of peptone-elicited PM, and no significant correlation was observed between the increase in γ -glucuronidase and γ–N-acetyl-D-glucosaminidase activities and the increase in anti-listerial activity. These results suggest that increase in the activity of lysosomal enzymes such as γ-glucuronidase and γ-N- acetyl-D-glucosaminidase is not correlated with the anti-listerial activity of PM. and that superoxide anion has very little effect on the anti-listerial activity of PM in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb02131.x
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  • 7
    Electronic Resource
    Electronic Resource
    Correlation of Susceptibility and Cytostatic Factor-Inducing Activity of Tumour Cells to Peritoneal Macrophages (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 27 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: L929, 3T12-3, B16, 3LL, and YAC1 cells with cytostatic factor (CF)-inducing activity from Lactobacillus casei-elicited murine peritoneal macrophages (LCEPM) were susceptible to the cytostatic activity of LCEPM and to LCEPM-produced CF, but L1210, P388D1, and Colon 26 cells, which have no CF-inducing activity, were resistant to that of LCEPM and to the CF. The resistance of P815 cells to that of LCEPM was stronger than that of 3T12-3 cells, but the CF-inducing activity of P815 cells was about 5098 weaker than that of 3T12-3 cells. Release of CF from LCEPM was also caused by heat-killed (100°C, 10 min) 3T12-3 or P813 cells, and this release was inhibited by d-mannose. The CF-inducing activity of heat-killed 3T12-3 or PK15 cells was reduced by mild trypsin digestion (37°C for 10 min). A d-mannose-containing glycopeptide or glycoprotein (GP) was separated from 3T12-3 or P815 cells by concanavalin A (Con A) or wheat germ agglutinini (WGA) affinity chromatography. The CF were released from LCEPM by stimulation with the Con A-binding GP of the tumour cells, but the WGA-binding GP had little activity.It is suggested that tumour cells with CF-inducing activity may he susceptible to the cytostatic activity of LCEPM, and those without CF-inducing activity may be resistant to the cytostatic activity of LCEPM and the release of CF from activated macrophages may be caused by the Con A-binding GP of the tumour cell surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02346.x
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  • 8
    Electronic Resource
    Electronic Resource
    Synthesis of CPT-11 (Irinotecan Hydrochloride Trihydrate) (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 803 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb26372.x
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  • 9
    Electronic Resource
    Electronic Resource
    Dimethylnitrosamine formation in the gastro-intestinal tract of rats
    Amsterdam : Elsevier
    Food and Cosmetics Toxicology 14 (1976), S. 553-556 
    Details
    ISSN: 0015-6264
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0015-6264(76)80007-7
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