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  • 2000-2004  (4)
  • 1955-1959
  • 1925-1929
  • 2001  (4)
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  • 2000-2004  (4)
  • 1955-1959
  • 1925-1929
Year
  • 1
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Boreholes have been constructed at eight sites on the Permo-Triassic Sandstone and Chalk aquifers to assess the extent of chemical and microbiological contamination emanating from unlined farm manure stores. Slurry along fracture faces in the Chalk was found on cores taken from beneath two stores. Porewaters from the Chalk sites and one of the Sandstone sites were discoloured and showed high concentrations of nitrate, ammonium and organic carbon to depths in excess of 10 m. Although Cryptosporidia and Escherichia coli O157 were found in many of the cattle slurry lagoons, neither were found in the aquifer material beneath. The self-sealing of unlined slurry stores is seen as a crucial step in minimizing leakage. A simple mass balance shows farm boreholes near to contaminant sources are at greater risk than public supply wells. Contaminant modelling shows discontinuing use of an unlined farm manure store will lead to little difference in solute concentrations over the short to medium term. Groundwater is most at risk where the water table is shallow since direct hydraulic connection between the lagoon base and the water table considerably increases the rate of vertical migration. This is of greatest significance for pathogens that are thought to be relatively short lived in the subsurface. Under the majority of situations minimal threat is posed to potable groundwater drinking supplies.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 59 (2001), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Estimates of back-calculated size at age provided no evidence of a growth spurt following sexual transition in the protogynous serranid Plectropomus maculatus. The results suggested that mature females that had a large size at age early in life changed sex to male.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 15 (2001), S. 0 
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The formation of nitrite in distribution systems has been understood for a number of years. This paper explains how controls have been developed based upon that knowledge, and how nitrite formation was reduced by 80% over a period of three years, in London's distribution system. Effective control measures and associated procedures included (a) forming process-optimisation teams, (b) setting realistic targets, and (c) producing a manageable and simple monitoring system - by training and communication, and using simple analytical equipment. Control measures included optimisation of the ammoniation process and increasing the chlorine concentration in the distribution system.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Infliximab is an established treatment for steroid-resistant and fistulating Crohn’s disease. Although efficacy has been shown in clinical trials, financial implications often limit its use and limited data exist regarding clinical practice.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To audit the clinical effectiveness of Infliximab.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:We prospectively audited 50 consecutive patients [28 females; median age, 34 years (17–70 years)]. Disease activity and response rates were assessed by the Harvey–Bradshaw index. Clinical and disease data were collected and blood was taken for inflammatory markers, complement and double-stranded DNA antibodies. Patients received Infliximab at 5 mg/kg and were followed for 12 weeks.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Indications for Infliximab were refractory Crohn’s disease in 39 patients, fistulating Crohn’s disease in six, pyoderma gangrenosum in one, pouchitis in two and coeliac disease in two. Thirty-one (79%) of the refractory Crohn’s disease patients and four (66%) of the fistulating patients responded at 4 weeks. Twenty-one (54%) of the refractory Crohn’s disease patients had a continued response at 12 weeks. Perianal disease was more prevalent in non-responders (7/8 vs. 12/31, P 〈 0.02).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Response rates to Infliximab in our group are comparable to those of clinical trials. Despite the expense, it remains a useful adjunct to treatment in this otherwise difficult group of patients. Patients with perianal disease responded less well in our cohort.
    Type of Medium: Electronic Resource
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