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  • 2000-2004  (8)
  • 1930-1934
  • 2003  (8)
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  • 2000-2004  (8)
  • 1930-1934
Year
  • 1
    Electronic Resource
    Electronic Resource
    A comparison of the forces exerted during laryngoscopy using disposable and non-disposable laryngoscope blades (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The concern that re-usable equipment may be a source of cross-infection has prompted the increased use of disposable laryngoscope blades. We conducted a study investigating the duration of laryngoscopy and the peak force generated using various laryngoscope blades. Five blades were studied: one reusable Macintosh 3 blade, one disposable metal blade and three plastic disposable blades. Sixty anaesthetists performed laryngoscopy on a mannequin using each of the five blades presented in a random order. This was then repeated with a rigid collar applied to the mannequin. The mean force applied with the collar off with the metal blades was 32.8 and 30.8 N, and with the plastic blades 37.3, 39.6 and 41.5 N, respectively (p 〈 0.0001). The mean force applied with the collar on with the metal blades was 30.5 and 32.5 N, and with the plastic blades 35.5, 34.9 and 31.4 N, respectively (p 〈 0.0001). The mean duration of laryngoscopy with the collar off for the metal blades was 5.6 and 5.4 s, and with the plastic blades 10, 7.2 and 7.5 s (p 〈 0.0001). The duration of laryngoscopy with the collar applied for the metal blades was 7.1 and 7.5 s, and with the plastic blades 11.8, 9.7 and 9.0 s (p 〈 0.0001). The use of plastic blades results in both greater peak force and duration of laryngoscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03340.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of personal, environmental and biological exposure of paediatric anaesthetists to nitrous oxide and sevoflurane (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Paediatric anaesthetists are at higher risk of exposure to waste anaesthetic gases, which often exceed set safety limits. Recommended personal diffusive sampling techniques for monitoring exposure to waste anaesthetic gases may not give a true profile of exposure and hence biological sampling may also be necessary. We evaluated the exposure of paediatric anaesthetists to nitrous oxide and sevoflurane as assessed by personal environmental and biological samples. The influence of venue and technique, and the strength of the relationship among the various sampling techniques were analysed. The study found that exposure to nitrous oxide during paediatric anaesthetic inductions is still a major problem, although exposure to sevoflurane was usually within the accepted limits. The type of breathing system used and the presence of scavenging seem to influence this exposure, though surprisingly, the induction technique or the methods of airway control do not. No significant relationship was found between the various biological indicators measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03235.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Adverse airway events during brief nasal inhalations of volatile anaesthetics: the effect of humidity and repeated exposure on incidence in volunteers preselected by response to desflurane (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Twelve volunteers known to have airways that responded adversely to 2.0 MAC desflurane were recruited. Each volunteer inhaled three single breaths of each of 0.5, 1.0 and 2.0 MAC of sevoflurane, halothane, isoflurane, desflurane and balance air, with breaths of air between, whilst breathing nasally through a face mask attached to one of three filters that provided three different levels of humidification. The incidence of any adverse airway events was recorded. The anaesthetic inhaled significantly affected the incidence of adverse airway events (p 〈 0.001), with the least to most irritant being sevoflurane, halothane, isoflurane and desflurane. Increasing the concentration of anaesthetic also significantly increased the incidence of adverse airway events (p 〈 0.001). The filter used, and hence the level of humidification, did not affect the incidence of adverse airway events (p = 0.09), but repeated exposure caused a significant reduction in the incidence of adverse airway events (p 〈 0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.02965.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The rigid nasendoscope as a tool for difficult tracheal intubation: A manikin study (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We examined the use of the 30° rigid nasendoscope in aiding difficult tracheal intubations. A Cormack and Lehane grade 4 difficult intubation (no view of glottis or epiglottis) was set up on a manikin. After 10 s of tuition, 40 anaesthetists attempted to pass a standard gum elastic bougie between the cords, with and without the nasendoscope, in randomised order. A bougie curved to an ‘optimal curve’ was also tested. Using the standard bougie 13/40 (33%) passed the bougie between the cords without the nasendoscope, compared with 31/40 (78%) when using the nasendoscope (p 〈 0.001). The ‘optimal curve’ bougie resulted in 29/40 (73%) and 39/40 (98%) success rates without and with the nasendoscope, respectively (p = 0.004). The nasendoscope is a simple and easy to use tool in grade 4 intubation, and results are improved further by the use of an ‘optimal curve’ bougie.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03203.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    An evaluation of the modified Airway Management Device (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the modified Airway Management Device (AMDTM) in 60 spontaneously breathing anaesthetised patients. The insertion and removal of the device was very easy and atraumatic. The airway was secured on the first attempt in 41 patients (70%; 95% CI 57–80%). The most important problem was loss of airway, which occurred in 11 patients (19%; 11–30%) during maintenance of anaesthesia. The AMD was dislodged during maintenance in one patient. There was a loss of the airway in 12 patients (20%; 12–31%); in 10, it was maintained with simple airway manoeuvres or a laryngeal mask airway and tracheal intubation was required in two patients. Ten of these patients were male and two were female; the failure rate was 33% (12–31%) among the male patients and 6% (2–22%) among the female patients. The cuff volumes ranged from 4 ml to 80 ml and cuff pressures from 6 cm H2O to 92 cm H2O. Blood was seen on removal in three patients (6%; 2–16%) and nine patients (18%; 10–30%) experienced sore throat after removal of the device.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03185.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Integration of Rapid Derivatization and Gradient Elution Techniques for Enhanced High-Performance Liquid Chromatography Analysis of Key Amino Acids in Wheat Flour (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A rapid pre-column derivatization process before ultraviolet chromatographic analysis using a Pico-Tag C18 column was developed in combination with modified gradient elution techniques for the analysis of key amino acids (proline and glutamine) in wheat flour. With use of a vacuum concentrator at 45°C, the pre-column derivatization process was significantly accelerated before entering a reverse-phase high-performance liquid chro-matography. When running at an optimized scheme—in which the gradient elution started at a flow rate of 1 mL/ min and then gradually increased to 1.3 mL/min in 22 min, followed by reset to 1 mL/min at 45 min—the profiled mobile phase mixture was able to yield chromatograms with desirable retention factor and resolution. Keywords: proline, glutamine, glutamic acid, reverse-phase HPLC, resolution
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb05786.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 43 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To determine whether the expression of DNA damage detection and repair proteins is frequently altered in breast carcinomas.Methods and results:  The expression profiles of five such proteins: ATM, p53, NBS1, MRE11 and Rad50 were analysed in 99 in-situ and invasive ductal breast carcinomas of different grades using an immunohistochemical approach, and compared with those seen in eight independent non-cancer (normal) breast samples and in the surrounding normal tissues of the breast carcinomas examined. ATM protein expression was reduced in 75% of the tumours compared with the levels found in normal tissues. Fewer tumours had reduced protein levels of the members of the MRE11, NBS1 and Rad50 (MNR) complex (31%, 46% and 28%, respectively) with p53 being over-expressed in 30%. In the majority of tumours (92%) we observed a good correlation between the expression of the three proteins of the MNR complex with low NBS1, MRE11 or Rad50 expression rarely found alone, suggesting that this event occurs subsequently to the deregulation in expression of other DNA repair proteins.Conclusion:  The pattern of protein changes observed supports our hypothesis that alterations in DNA double-strand break repair capacity are involved in mammary carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01713.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The use of nitrous oxide in anaesthetic practice: a second questionnaire survey (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.306923.x
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    Paper (German National Licenses)
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