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  • 2015-2019
  • 2000-2004
  • 1995-1999  (14)
  • 1960-1964
  • 1925-1929
  • 1830-1839
  • Life and Medical Sciences  (9)
  • PTCA  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Myokardperfusion und -funktion nach Koronarinterventionen (1998)
    Springer
    Der Internist 39 (1998), S. 713-719 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Koronarreserve ; Myokardinfarkt ; Therapie ; PTCA ; Koronare Herzkrankheit ; Diagnostik ; Hibernation ; Stunned Myokardium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Ein bei Belastung zunehmender Sauerstoffbedarf des Myokards kann im wesentlichen nur durch eine Steigerung der Koronardurchblutung gedeckt werden. Dies geschieht zu ca. 90% durch Dilatation der arteriolären Widerstandsgefäße und nur zu ca. 10% durch Dilatation der epikardialen Koronargefäße, die angiographisch sichtbar gemacht werden können. Die Differenz zwischen Ruhe- und maximal möglichem Blutfluß wird als Koronarreserve bezeichnet. Die Messung des koronaren Blutflusses, der Perfusion, des myokardialen Stoffwechsels sowie der Auswirkung auf die Myokardfunktion erfolgt durch verschiedenste Verfahren: Thallium-Szintigraphie, Positionen-Emissions-Tomographie, Magnetresonanztomographie, Clearance-Methoden, Doppler- und Kontrastechokardiographie, intrakoronare Doppleruntersuchungen u.s.w. Die mittels Koronarangiographie mögliche morphologische Beschreibung und Quantifizierung von Stenosedurchmessern ist hierzu nicht die Methode der Wahl. Die Ergebnisse dieser Untersuchungen bei verschiedenen koronarbedingten Erkrankungen und die Evaluierung von Therapiestrategien stehen im Mittelpunkt dieser Arbeit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050234
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  • 2
    Electronic Resource
    Electronic Resource
    Aktuelle Therapie der koronaren Herzkrankheit Interventionelle Maßnahmen (1997)
    Springer
    Der Internist 38 (1997), S. 1179-1190 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Koronare Herzkrankheit ; Therapie ; Koronare Herzkrankheit ; PTCA ; Koronare Herzkrankheit ; interventionelle Therapie ; Stents ; PTCA ; Myokardinfarkt ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema In der Behandlung des akuten Myokardinfarkts ist die PTCA fest etabliert. Bezüglich der koronaren Herzkrankheit konkurriert die PTCA allerdings besonders in Hinblick auf die Prognose des Leidens mit der medikamentösen Therapie und der aortokoronaren Bypassoperation. Welche Behandlungsstrategien und welche Indikationsstellungen im Einzelfall favorisiert werden können oder auch nicht, haben zahlreiche Studien in den letzten Jahren gesichert. Über das technische Vorgehen bei PTCA, Ergebnisse, Management und Restenosen nach PTCA sowie über den Vergleich der verschiedenen Therapieformen wird hier eingehend berichtet. Breiten Raum nimmt die Darstellung von Indikationen und Kontraindikationen und schließlich die interventionelle Behandlung des akuten Myokardinfarkts ein. Die bemerkenswerten Methoden der Stentimplantation zur Prävention von Reokklusionen einschließlich der technischen Weiterentwicklung von Stents sind faszinierend und für die erfolgreiche Senkung von Morbidität und Mortalität der koronaren Herzkrankheit und ihrer Komplikationen von hoher Bedeutung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050130
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  • 3
    Electronic Resource
    Electronic Resource
    Improvement of coronary morphology and blood flow after stenting (1995)
    Springer
    The international journal of cardiovascular imaging 11 (1995), S. 81-87 
    Details
    ISSN: 1573-0743
    Keywords: intravascular ultrasound ; intracoronary Doppler ; stenting ; PTCA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravascular ultrasound (IVUS) and intracoronary Doppler (ICD) were performed in eight patients (54.3±6.5 years, 6 male) immediately after PTCA and after stenting. ICD was also performed before PTCA. After PTCA, IVUS has demonstrated intimal rupture in all patients. After stenting, IVUS revealed wall wrapping of the intimal flap with a free lumen in all patients. The lumen diameter was 2.42±0.55 mm after PTCA and was 2.74±0.49 mm after stenting (p〈0.001). The cross-sectional area increased from 4.70±1.99 mm2 post-PTCA to 6.40±2.15 mm2 post-stent (p〈0.005). Coronary flow velocity reserve, calculated by the ratio of mean flow velocity at rest and after intracoronary papaverine administration, increased from 2.05±1.01 to 2.99±1.14 after PTCA (p = 0.015); and increased to 4.51±1.33 after stenting (p〈0.001). The morphological data derived from IVUS correlated with the functional information obtained with ICD. In addition to its established role in bail out situations, stent implantation may be considered when a suboptimal morphological and functional result has been demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844705
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  • 4
    Electronic Resource
    Electronic Resource
    Intrakoronare Interventionen in der Frühinfarktphase (1997)
    Springer
    Intensivmedizin und Notfallmedizin 34 (1997), S. 266-270 
    Details
    ISSN: 1435-1420
    Keywords: Key words Coronary intervention ; PTCA ; acute myocardial infarction ; stent-implantation ; rescue-PTCA ; direct-PTCA ; primary PTCA ; Schlüsselwörter Koronarintervention ; PTCA ; akuter Myokard-infarkt ; Stent-Implantation ; Rescue-PTCA ; direkte PTCA ; primäre PTCA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Während die intravenöse Thrombolysetherapie weiterhin als Goldstandard der Reperfusionsbehandlung des akuten Myokardinfarktes gilt, sind in den vergangenen Jahren auch zunehmend mechanische Reperfusionsstrategien untersucht worden. Zunächst wurde das Konzept der routinemäßigen Sofort-PTCA nach Thrombolysebehandlung untersucht, das wegen einer höheren Komplikationsrate im Vergleich zur alleinigen Thrombolysetherapie jedoch keine Verbreitung fand. Beim Konzept der Rescue-PTCA erfolgt eine mechanische Rekanalisation und Dilatation nur im Falle eines dokumentierten persistierenden Gefäßverschlusses nach Thrombolysetherapie. Für dieses Konzept konnte eine verbesserte Überlebensrate und Ventrikelfunktion belegt werden. Das zuletzt untersuchte Konzept der primären PTCA, bei dem die PTCA ohne vorhergehende thrombolytische Therapie routinemäßig durchgeführt wird, zeigte im Vergleich zur Thrombolysetherapie eine signifikant geringere Letalität, Reinfarktrate und Inzidenz zerebraler Insulte. Der erhebliche logistische Aufwand steht jedoch einer weiteren Verbreitung dieser Therapieform entgegen. Gegenwärtig sollten daher mechanische Reperfusionsmaßnahmen, insbesondere bei den Patienten mit akutem Myokardinfarkt erwogen werden, bei denen eine thrombolytische Therapie kontraindiziert ist, ein kardiogener Schock vorliegt oder ein anderes Krankheitsbild differentialdiagnostisch abgegrenzt werden muß. Gegebenenfalls sollte auch bei älteren Patienten (〉75 Jahre) von einer Thrombolysebehandlung zugunsten mechanischer Reperfusionsmaßnahmen Abstand genommen werden. Nach erfolgter Thrombolysetherapie sollte bei fehlenden Reperfusionszeichen eine Herzkatheteruntersuchung und im Falle eines persistierenden Gefäßverschlusses eine mechanische Rekanalisation im Sinne der Rescue-PTCA angestrebt werden.
    Notes: Summary Although thrombolysis remains the gold standard in the treatment of acute myocardial infarction, mechanical reperfusion strategies have been introduced into the clinical routine within recent years. The concept of a routinely performed immediate PTCA following thrombolysis was combined with a higher complication rate compared to thrombolysis alone and was therefore abandoned. The concept of rescue-PTCA, where PTCA is performed only in case of persistent occlusion of the infarct-related artery, led to a better left ventricular function and higher survival rate. The relatively new concept of primary PTCA, which is performed routinely without preceding thrombolysis, revealed a significantly lower mortality, reinfarction rate and incidence of cerebral bleedings compared to thrombolysis. Currently, the following strategy for patients with acute myocardial infarction is recommended. In patients with cardiogenic shock, contraindications to thrombolysis, an unclear diagnosis or advanced age (more than 75 years) mechanical reperfusion should be the preferred strategy. In case of persistent or recurrent ischemia, electrical or hemodynamic instability following thrombolysis, coronary angiography and, in case of need, rescue-PTCA should be performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003900050048
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  • 5
    Electronic Resource
    Electronic Resource
    Tissue Doppler echocardiography: a new method of evaluating perfusion-dependent myocardial function during PTCA (1997)
    Springer
    The international journal of cardiovascular imaging 13 (1997), S. 99-103 
    Details
    ISSN: 1573-0743
    Keywords: myocardial function ; myocardial ischemia ; myocardial perfusion ; PTCA ; tissue Doppler echocardiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The increasing demand for insight into the relationship between coronary perfusion and myocardial function stimulated the development of tissue Doppler echocardiography. This new technique was applied simultaneously with PTCA of a subtotal LAD lesion (single vessel disease, no collaterals) in a 68-year-old patient suffering from unstable angina pectoris. Prior to the conventional signs of ischaemia a decrease in myocardial tissue velocities and a loss of color-coded heart cycle intervals was observed. A myocardial velocity gradient calculated from the higher subendocardial and lower subepicardial velocity decreased from 3.3 to 1.3. This decrease was prevented by an active autohaemoperfusion device which supplied blood distally to an insufflated balloon (60 ml/min). Thus, contractility and viability might be maintained by preserving myocardial velocity gradients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005783328371
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  • 6
    Electronic Resource
    Electronic Resource
    Prenatal development of the integument in Delphinidae (Cetacea: Odontoceti) (1995)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 223 (1995), S. 269-287 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The prenatal development of epidermis, dermis, and hypodermis was studied in embryos of different ago of two delphinid species (Stenella attenuata, Delphinus delphis), using light and transmission electron microscopical methods. The delphinid embryo is covered by a multilayered tissue formed by four different epidermal generations (periderm, stratum intermedium-I, str. intermedium-II, str. spinosum) produced by the str. basale. The first layer appears at about 40-50 mm of body length, the second type (s.i.-I) about 60-160 mm, and the third type (s.i.-II) is present at 160-500 mm. The first spinosal cells are produced at 225-260 mm body length; thenceforth, the epidermis increases continuously in thickness. Epidermal ridge formation begins about 400-mm body length. The development of the dermis is characterized by the early production of thin connective tissue fibers (40- 70-mm body length) and simultaneously the cutaneuous muscle matures in structure. Vascular development intensifies between embryos of 150-225 mm, and collagen production increases markedly in fetuses of 225-260-mm length. These events are paralledled by an increase in dermal thickness. The first elastic fibers can be recognized in the skin from the abdomen at about 600-mm body length. The development of the hypodermis is marked by very rapid and constantly progressing growth, beginning about 60-mm body length. The first typical fat cells appear in animals of 360-400 mm. Regional differences are obvious for all skin layers with regard to the flippers, where structural maturation proceeds more rapidly than in dorsal or abdominal regions. © 1995 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1052230305
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  • 7
    Electronic Resource
    Electronic Resource
    Tubulin gene expression during growth and maturation of leaves with different developmental patterns (1995)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 30 (1995), S. 67-72 
    Details
    ISSN: 0886-1544
    Keywords: Nicotiana ; Hordeum ; microtubule ; cell differentiation ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Changes in the tubulin-protein and -poly(A)+RNA contents were monitored by means of Western and Northern blot analyses, respectively, during growth and maturation of leaves of a dicotyledonous (tobacco) and monocotyledonous (barley) plant. It was recently argued from immunofluorescence and preliminary biochemical data that the density of microtubular networks and concomitantly the tubulin content are distinctly reduced after cessation of cell growth in leaves [Jung et al., 1993]. The results presented now confirm and extend this view. There appeared to be clear differences between the monocot and the dicot: (1) the loss of tubulin during leaf development was much slower in the dicot than in the monocot leaves (within months instead of days); (2) the degree of loss was more dramatic in the monocot leaf and only very low threshold levels of tubulin were retained in fully differentiated tissues; and (3) the loss of tubulin in the monocot leaf tissue appeared to be correlated with the decrease in the mRNA content, whereas the high level of tubulin-RNA in fully differentiated or even almost senescent dicot leaves indicated a gene expression control at the posttranscriptional level.The comparatively rapid and very distinct tubulin-protein and -RNA disappearance during development of the monocot leaf tissues confirm at the molecular level that differentiation proceeds much faster and is much more determinative in these leaves, as was postulated from histological and physiological data. The differences in the behaviour of the microtubular cytoskeleton perhaps even reflect the differences in the ability of the differentiated leaf cells to dedifferentiate, i.e., to establish new sets of microtubules and to reenter the mitotic cell cycle, e.g., during would response, tumour induction or in vitro culture. © 1995 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970300108
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  • 8
    Electronic Resource
    Electronic Resource
    Cellular composition of milky spots in the human greater omentum: An immunochemical and ultrastructural study (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 241 (1995), S. 163-174 
    Details
    ISSN: 0003-276X
    Keywords: Human greater omentum ; Milky spots ; Macrophages ; Lymphocytes ; Light microscopy ; Electron microscopy ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Background: Milky spots in the greater omentum of some animals are well organized perivascular infiltrated of leucocytes, and are considered to have characteristics of secondary lymphoid tissue. To determine whether milky spots in the human greater omentum can also be regarded as secondary lymphoid tissue, we studied milky spots in an unstimulated state.Methods: Patients were selected on the basis of absence of disease in the peritoneal cavity that might influence the state of the milky spots. Using monoclonel antibodies aganist macrophages, B-lymphocytes and T-lymphocytes, and immunoperoxidase labeling, the number of these cells and their location in milky spots were studied by light microscopy. However, the stromal components of the greater omentum, especially those within the milky spots, were studied by electron microscopy.Results: Milky spots in the human greater omentum are relatively uniform vascularized accumulations of mononuclear cells comprising macrophages (67.9% ± 9.4, mean ± standard deviation), B-cells (10.1% ± 3.4), T-cells (10.2% ± 3.7), and mast cells. However, no special B-cells and T-cell areas could be distinguished. On the ultrastructural level it was demonstrated that macrophages are present in different stages of maturation and can enter or leave the milky spots. Furthermore, no cells characteristic of secondary lymphoid organs, such as interdigitating cells or follicular dendritic cells, were seen.Conclusions: These data indicate that unstimulated milky spots in the human greater omentum are to a great extent just a preformed specific accumulation of primarily macrophages within the stroma of the greater omentum, and therefore, cannot be regarded as true secondary lymphoid tissue. Milky spots could serve as a gateway for, as well as a provider of pertioneal macrophages when the intra-abdominal status so requires.Finally, the data from this study are compard with the data of other studies of human milky spots and those in animals. © 1995 Wiley-Liss, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092410204
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  • 9
    Electronic Resource
    Electronic Resource
    1,25(OH)2D3-dependent regulation of calbindin-D28k mRNA requires ongoing protein synthesis in chick duodenal organ culture (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 58 (1995), S. 315-327 
    Details
    ISSN: 0730-2312
    Keywords: calbindin-D28k ; 1,25-dihydroxyvitamin D3 ; messenger RNA ; organ culture ; polymerase chain reaction ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Organ culture of 19-day-old chick embryo duodena was utilized to evaluate the mechanism of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-dependent calbindin-D28k (CaBP) expression. Duodenal CaBP and 1,25(OH)2D3 receptor (VDR) expression were assessed by Western blot analysis, while CaBP and VDR mRNA levels were determined by Northen blot analysis. In untreated duodena, both VDR protein and mRNA were present, while CaBP protein and mRNA were undetectable. Treatment of cultured duodena with 25 nM 1,25(OH)2D3 resulted in detectable CaBP mRNA after 4 h which continued to increase during a 24 h time period. Under these conditions, localization of [3H-1β]1α,25(OH)2D3 in duodenal chromatin is rapid (≤ 30 min). Thus, the delayed accumulation of detectable CaBP mRNA cannot be explained by slow nuclear binding of 1,25(OH)2D3. The inclusion of 1.6 μM actinomycin D in the organ culture partially inhibited the 1,25(OH)2D3-regulated increase in CaBP mRNA, which implies that there is a transcriptional component involved in the increased CaBP mRNA levels. Similarly, quantitative polymerase chain reaction studies allowed the detection of CaBP pre-mRNA and mRNA sequences 1 h after hormone treatment, suggesting that CaBP gene transcription is initiated rapidly. Treatment of cultures with 36 μM cycloheximide 1 h prior to 1,25(OH)2D3 addition resulted in superinduction of VDR mRNA levels but sharply reduced CaBP steady-state mRNA levels. This dramatic reduction in CaBP mRNA reveals that 1,25(OH)2D3-mediated CaBP expression is dependent on ongoing protein synthesis. Thus, we propose that a labile auxiliary protein or other cofactor, which may or may not be 1,25(OH)2D3-dependent, is necessary for 1,25(OH)2D3-mediated CaBP gene transcription in chick duodena.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240580306
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  • 10
    Electronic Resource
    Electronic Resource
    Computer networked scanning electron microscope for teaching, research, and industry applications (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Microscopy Research and Technique 32 (1995), S. 330-336 
    Details
    ISSN: 1059-910X
    Keywords: Scanning electron microscopy ; Teaching ; Computer ; Network ; Remote control ; Ethernet ; Internet ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: A laboratory designed for teaching the operation of a scanning electron microscope (SEM) has been developed. The laboratory makes use of a computer network to allow remote operation of the SEM. Movable teaching stations, consisting of a computer, TV monitor, and joystick control, enable students to view the image on the SEM screen, move the sample, control the basic operating parameters of the microscope, and acquire X-ray spectra. Images can also be stored on the computers for image analysis or incorporation into reports. The great advantage of the system is that it has been designed to be flexible enough to allow operation from any location that has access to the Internet. The system is relatively inexpensive and uses nonproprietary computer technology available at any computer store. While the laboratory has been designed for teaching, the concept of a multiuser SEM facility that is inexpensive and easy to install should have applications in both industrial and research settings. © 1995 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1070320407
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