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  • 1
    ISSN: 1432-1440
    Keywords: Nisoldipine ; Thromboxane B2 ; 6-Oxo-prostaglandin F1α ; Platelet aggregation ; Blood pressure ; Placebo-controlled study ; Human volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of the calcium antagonist nisoldipine on collagen-induced platelet aggregation and platelet thromboxane formation was studied ex vivo in healthy male volunteers in a double-blind, placebo-controlled crossover design. Measurements of general haemodynamics, immunoreactive 6-oxo-prostaglandin F1α and thromboxane B2 ex vivo and collagen-induced (0.6 and 2.5 µg/ml) platelet aggregation were performed immediately before (time 0), 0.5 h, 1 h and 2 h after ingestion of 10 mg nisoldipine or an identical placebo tablet. Compared with the control response at time 0, administration of nisoldipine resulted in a significant inhibition of both low-collagen-induced platelet aggregation and formation of immunoreactive thromboxane B2 at time 0.5 h. There were no changes in heart rate or systolic blood pressure but a significant decrease in diastolic blood pressure by nisoldipine at 1 h. No such change was obtained with placebo and there were also no alterations with nisoldipine in platelet aggregation and thromboxane formation after stimulation by high-dose collagen at this or any other time of the study. The data demonstrate a platelet-in-hibitory potential of nisoldipine in healthy men which is probably related to an increased resistance of the platelet membrane against foreign stimuli.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 545-551 
    ISSN: 1432-1440
    Keywords: Iloprost ; Antiplatelet actions ; Blood pressure ; Regional perfusion ; Peripheral arterial obliterative disease (PAOD) ; Dose-response study ; Controlled trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The dose-dependent inhibition of platelet aggregation by the chemically stable, prostacyclin-mimetic, iloprost, was studied in patients suffering from stage II–III peripheral arterial obliterative disease (PAOD). The study was designed as a randomized placebo-controlled cross-over trial. Iloprost was administered i.v. to six patients at doses of 0.5, 1.0, 2.0 or 3.0 ng/kg×min for 4 h, with an interval of 2–3 days between the infusions. During iloprost infusion, systolic and diastolic arterial blood pressure, heart rate and blood flow in the affected limb remained unchanged. In contrast, there was a considerable, dose-dependent inhibition of ADP- and thrombin-induced platelet aggregation and secretion ex vivo at doses of 0.5–2.0 ng/kg×min iloprost, indicating that iloprost reduced platelet stimulation by 50%–70%. The antiplatelet action of iloprost remained unchanged during infusion but ceased with 2 h after administration had ended. The agent was tolerated by the patients without unacceptable side-effects at doses up to 2 ng/kg × min. It is concluded that iloprost administered i.v. at doses of 1–2 ng/kg×min in patients with stage II–III PAOD does not involve haemodynamic side-effects and might be considered an effective antiplatelet agent.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 43 (1992), S. 629-633 
    ISSN: 1432-1041
    Keywords: Molsidomine, SIN-I, Neutrophil leucocytes ; Aglucuronidase, superoxide anions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The nitrovasodilator and nitric oxide donor molsidomine and its metabolite SIN-I dilate vascular smooth muscle and inhibit platelet activation by increasing intracellular concentrations of cyclic GMP We have therefore studied the effects of molsidomine and SIN-I on isolated human polymorphonuclear leucocytes (PMN)in vitro andex vivo. In vitro molsidomine dose-dependently reducedβ-glucuronidase release and the generation of superoxide anions from non-activated and from FMLP- or PAF-stimulated human PMNs. SIN-1 was equally effective in reducing (β-glucuronidase release and totally inhibited oxygen radical generation at a concentration of 580 μmol · l−1. In a double-blind, placebo-controlled, randomized trial we also studiedβ-glucuronidase release and the generation of superoxide anions from isolated PMNs. Blood was drawn from 12 healthy volunteers before and 3 h after oral molsidomine (16 mg) or placebo. There was no statistically significant difference inβ-glucuronidase release and superoxide anion formation when the PMNs were isolated before or after molsidomine or placebo. This was the case for non-activated, as well as FMLP- or PAF-stimulated PMNs. Thus, the nitric oxide donors molsidomine and its metabolite SIN-I caused a dose-dependent inhibition of PMN functionsin vitro, but no significant inhibition when the PMNs were isolated after oral molsidomine.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The diversity of symbiotic dinoflagellates (SD) from seven coral species (Fungia scutaria, Fungia paumotensis, Lep-tastrea transversa, Pavona cactus, Pocillopora verrucosa, Montastrea curia, and Acropora fonnosa) was studied in a restricted geographical area, the Lagoon of Arue on the island of Tahiti. Their diversity was explored by small subunit ribosomal RNA gene (SSU rDNA) restriction fragment length polymorphism (RFLP). After a nested amplification with SD specific primers, RFLP analyses were performed directly and after a cloning step. The diversity of these different SSU rDNA was estimated in respect to possible technical artifacts. In an axenic culture of SD from the coral Galaxea fascicularis, both heterogeneous SSU rDNAs and artifact molecules were observed as in our SD samples. According to the number of patterns observed, corals Fungia paumotensis, Leptastrea transversa. Pavona cactus, Montastrea curia, and Acropora fonnosa contained one class of SD SSU rDNAs. whereas Fungia scutaria and Pocillopora verrucosa contained three and two classes of SD SSU rDNAs respectively. In the limited geographic area studied. SD from different coral species shared the same pattern, except SD from Montastrea curta, which showed a unique pattern. In addition to the possibility of SD flux among different coral species, specific mechanisms could also be involved in the establishment of a symbiosis.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 19 (1987), S. 243-250 
    ISSN: 0022-2828
    Keywords: Coronary artery ligation ; Creatine kinase ; Iloprost ; Membrane phospholipids ; Myocardial ischemia ; Pressure-rate index
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Kardiologie 89 (2000), S. 464-468 
    ISSN: 1435-1285
    Keywords: Key words Cardiac tamponade – cardio-pulmonary resuscitation – retropharyngeal abscess –streptococcus milleri ; Schlüsselwörter Perikardtamponade – kardiopulmonale Reanimation – Retropharyngealabzeß–Streptococcus milleri
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über eine 67jährige Patientin, die im Rahmen einer Perikardtamponade plötzlich reanimationsbedürftig wurde. Die Ergußdrainierung zeigte eine putride Flüssigkeit, aus der Streptococcus milleri isoliert werden konnte. Fremdanamnestisch litt die Patientin schon 4 Tage vor dem Ereignis an einer allgemeinen körperlichen Schwäche, Dyspnoe, Fieber bis 39°C, Halsschwellung und Schluckbeschwerden. In einer CT-Untersuchung zeigte sich eine Entzündungsstraße ausgehend von der rechten Tonsille über das Mediastinum bis hin zum Perikard. Nach operativer Sanierung des retropharyngealen Abszesses heilte die Erkrankung vollständig aus. Das Krankheitsbild der eitrigen Perikardtamponade muß differentialdiagnostisch immer an einem hämatogenen, lymphogenen oder per continuitatem sich ausbreitenden Prozeß denken lassen. Der Erregernachweis im Erguß sowie die typische Anamnese ließen an eine oropharyngeale Ursache denken.
    Notes: Summary We present the case of a 67 year old woman who was resuscitated due to cardiac tamponade. Examination of the pus fluid showed a bacterial infection with streptococcus milleri. Four days before resuscitation the patient experienced weakness, dyspnoe, increased temperature (39° C), swelling of the neck, and pain on swallowing. Using computed tomography, examination revealed an infection extending from the right tonsil to the mediastinum and into the pericardium. After surgery to remove the retropharyngeal abscess, the patient healed well. Therefore, on presentation of a cardiac tamponade, possible hematogenous or lymmphogenous causes or per continuitatem infections should always be considered. In this case the germs in the fluid and the typical patient history indicated an oropharyngeal reason.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 38 (1997), S. 1168-1178 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Koronare Herzkrankheit ; Akutes Koronarsyndrom ; Antianginosa ; Antithrombotika ; Instabile Angina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema In der vorliegenden Arbeit wird der gegenwärtige Stand der Prävention und der medikamentösen Behandlung der koronaren Herzkrankheit aufgezeigt. Auf vielen verschiedenen Feldern konnten Erfolge erzielt und frühere Ergebnisse durch experimentelle Forschung oder klinische Studien gesichert werden. Das gilt besonders für den Einsatz von Azetylsalizylsäure zur Sekundärprophylaxe koronarer Ereignisse und kombiniert mit Fibrinolytika beim akuten Myokardinfarkt sowie kombiniert mit niedermolekularem Heparin beim akuten Koronarsyndrom. Direkte Thrombinantagonisten, Glykoprotein-Rezeptorantagonisten, Ticlopidin sowie neue und weiterentwickelte Fibrinolytika erbrachten große Fortschritte. Der molekulare Wirkungsmechanismus, der seit 1867 therapeutisch eingesetzten Nitrate wurde in den letzten Jahren aufgeklärt und die Substanz Stickstoffmonoxid (NO) identifiziert, die durch Nitrate freigesetzt zur Vasodilatation führt, zuvor umschrieben als Endothelium Derived Relaxing Factor (ERDF). NO ist die Schlüsselsubstanz eines zellulären Regulationsmechanismus, der in vielfältiger Weise positive und negative Wirkungen hat (vgl. dazu DER INTERNIST, Maiheft 1997). Betarezeptorenblocker und Kalziumantagonisten wurden weiterentwickelt. Unter klinischen Gesichtspunkten erscheint mit dem akuten Koronarsyndrom ein neuer Begriff, unter dem die instabile Angina pectoris und der intramurale Infarkt (ohne bzw. mit Enzymerhöhung) zusammengefaßt werden. Es bestehen viele Gründe, diese Erkenntnisse synoptisch darzustellen und unter der Fragestellung dieses Heftes „Was ist gesichert in der Therapie” zu bewerten.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 38 (1997), S. 1179-1190 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Koronare Herzkrankheit ; Therapie ; Koronare Herzkrankheit ; PTCA ; Koronare Herzkrankheit ; interventionelle Therapie ; Stents ; PTCA ; Myokardinfarkt ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema In der Behandlung des akuten Myokardinfarkts ist die PTCA fest etabliert. Bezüglich der koronaren Herzkrankheit konkurriert die PTCA allerdings besonders in Hinblick auf die Prognose des Leidens mit der medikamentösen Therapie und der aortokoronaren Bypassoperation. Welche Behandlungsstrategien und welche Indikationsstellungen im Einzelfall favorisiert werden können oder auch nicht, haben zahlreiche Studien in den letzten Jahren gesichert. Über das technische Vorgehen bei PTCA, Ergebnisse, Management und Restenosen nach PTCA sowie über den Vergleich der verschiedenen Therapieformen wird hier eingehend berichtet. Breiten Raum nimmt die Darstellung von Indikationen und Kontraindikationen und schließlich die interventionelle Behandlung des akuten Myokardinfarkts ein. Die bemerkenswerten Methoden der Stentimplantation zur Prävention von Reokklusionen einschließlich der technischen Weiterentwicklung von Stents sind faszinierend und für die erfolgreiche Senkung von Morbidität und Mortalität der koronaren Herzkrankheit und ihrer Komplikationen von hoher Bedeutung.
    Type of Medium: Electronic Resource
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