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  • 1
    Electronic Resource
    Electronic Resource
    Fertilizer Nitrogen Analyses, Apparent Loss of Organic Nitrogen in Fertilizers Containing Urea and Natural Organics (1958)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 6 (1958), S. 833-838 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60093a003
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  • 2
    Electronic Resource
    Electronic Resource
    Vacancy Formation in Molybdenum and Tungsten Investigated by Positron Lifetime Measurements (1987)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 15-18 (Jan. 1987), p. 145-148 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.15-18.145.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB (1999)
    Springer
    Diabetologia 42 (1999), S. 222-232 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Oxidative stress ; nephropathy ; transcription factor NF-kB ; thrombomodulin ; thioctic acid.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kB activation in ex vivo isolated peripheral blood mononuclear cells. We examined 33 patients with diabetes mellitus (Type I and Type II). Patients with diabetic nephropathy showed higher NF-kB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kBp65 than patients without renal complications. NF-kB binding activity correlated with the degree of albuminuria (r = 0.316) and with thrombomodulin plasma concentrations (r = 0.33), indicative for albuminuria associated endothelial dysfunction. In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (α-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48 % and NF-kB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38 %.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051142
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  • 4
    Electronic Resource
    Electronic Resource
    Beobachtungen zum Epithelkörperchencarcinom (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 613-620 
    Details
    ISSN: 1432-1440
    Keywords: Parathyroid carcinoma ; Diagnosis of parathyroid carcinoma ; Therapeutic implications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It deserves special attention in regard to diagnosis and treatment. Within a period of 10 years we observed 117 patients with primary hyperparathyroidism (pHPT) at the University Hospitals of Ulm and Heidelberg. In five patients a parathyroid carcinoma was found, corresponding to an incidence of 4.4%. In four of five patients no clinical signs were evident preoperatively indicating a parathyroid malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721916
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  • 5
    Electronic Resource
    Electronic Resource
    Morphologische Veränderungen der Beckenkammspongiosa beim primären Hyperparathyreoidismus und ihre Bedeutung für die Diagnostik (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 643-653 
    Details
    ISSN: 1432-1440
    Keywords: Primary hyperparathyroidism ; Histomorphometry ; Trabecular bone structure ; Parathyroid hormone ; Bone biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Iliac crest bone biopsy specimens of 391 patients with surgically proven primary hyperparathyroidism were investigated. In 60 unselected cases quantitative analysis of trabecular bone changes was performed. The age of the patients ranged between 12 and 85 years. The observed morphological findings were divided into four stages. In a few cases no differences from normal bone tissue could be observed. In 46% occurrence of a nonspecific increase of osteoid seams, osteoblasts, and osteoclasts was observed. Of the cases 50% showed a specific, but very often mild endosteal fibrosis. Only in 4% was there a severe fibroosteoclasia with development of so-called brown tumors. The quantitative analysis showed an increase of trabecular bone mass as well as of remodeling surfaces. But there was an overlap of up to 25% with the normal controls. The results demonstrate the influence of parathyroid hormone peptides on bone morphology. However, the investigation of a bone biopsy specimen is not generally very useful for diagnostic purposes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875499
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  • 6
    Electronic Resource
    Electronic Resource
    Secretion of calcitonin and carcinoembryonic antigen in long-term organ culture of human medullary thyroid carcinoma: Biochemical and immunocytochemical studies (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 205-210 
    Details
    ISSN: 1432-1440
    Keywords: Calcitonin ; Carcinoembryonic antigen ; Medullary thyroid carcinoma in vitro ; Organ culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tissue cultures of four C-cell carcinomas (medullary thyroid carcinoma, MTC) were prepared to study the basal and stimulated calcitonin (CT) and carcinoembryonic antigen (CEA) release. Immunohistological staining of the explants for CT and CEA have been performed after various periods of culture. These MTC explants were able continuously to release CT and CEA for periods up to 157 days. The spontaneous CT and CEA release decreased sharply during the 1st week of culture, then remained nearly constant over the observation period. The CEA/CT secretion ratio slightly declined during long-term culture; CEA release seems to drop earlier than CT production. CT and CEA could be detected in the same cells by immunocytochemical technique. The septal tissue consisting of dense connective tissue and amyloid produced by tumor cells seemed to increase during long-term culture. CT, but not CEA, was stimulated by pentagastrin (10−5 M), glucagon (6×10−6 M), and dose related by calcium (2.5–20 mM) in vitro. The MTC explant organ long-term culture proved to be a useful model for studies of human CT and CEA secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731170
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  • 7
    Electronic Resource
    Electronic Resource
    Katacalcin — Ein neuer Tumormarker beim C-Zell-Karzinom der Schilddrüse (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 82-86 
    Details
    ISSN: 1432-1440
    Keywords: Katacalcin ; Tumor marker ; C-cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Katacalcin (KC) is situated on the C-terminal side of the procalcitonin molecule and is cleaved like calcitonin (CT) from this precursor peptide. Serum levels of KC were measured in 22 patients with C-cell carcinoma with a specific and sensitive radioimmunoassay (normal range, 〈0.1–0.15 ng/ml). Basal serum KC values in C-cell carcinoma patients were 0.32-290 ng/ml. There was a good correlation between KC and CT (r=0.98,P〈0.001). Serum KC, as well as CT, markedly increased after pentagastrin and calcium infusion. KC and CT were secreted in nearly equimolar amounts. During selective venous catheterization, KC and CT levels were increased in serum samples from veins draining tumor masses, which could be confirmed operatively. During the follow up, KC and CT measurements correlated well to the stage of disease. KC could be immunohistologically localized in C-cell carcinoma tissue. As a tumor marker, katacalcin is likely to be as useful as calcitonin in C-cell carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745480
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  • 8
    Electronic Resource
    Electronic Resource
    Briefe an die Redaktion (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 557-558 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719785
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  • 9
    Electronic Resource
    Electronic Resource
    Über die Einwirkung von Thyreocalcitonin auf die Phosphaturie (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 34-38 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Thyrocalcitonin extracted from the thyroid glands of the hog caused a fall in serum calcium in the dog within 30 min, in the rat within 45 min, respectively. The most effective dose of thyrocalcitonin on the serum calcium of the intact rat showed a small increase in radiophosphaturia of the parathyroidectomized rat which was statistically significant. When thyrocalcitonin and PTH were injected simultaneously a decrease in the effect of parathyroid hormone on phosphaturia was observed. Triiodthyronine did not influence the phosphaturic system. Perhaps thyrocalcitonin inhibits competitively the activity of PTH on the kidney tubules. So far the phosphaturic effect of thyrocalcitonin has not been defined in terms of specificity.
    Notes: Zusammenfassung Thyreocalcitonin in Schilddrüsenextrakten führte nach 30 min beim Hund, nach 45 min bei der Ratte zum Abfall des Serumcalciums. Die am Serum-Ca der intakten Ratte maximal wirksame Thyreocalcitonindosis steigerte die Radiophosphaturie der parathyreoidektomierten Ratte mäßig stark, aber statistisch signifikant. Dagegen führte die gleichzeitige Gabe von Thyreocalcitonin und PTH zu einer markanten Verminderung des PTH-Effektes. Trijodthyronin beeinflußte des phosphaturische System nicht. Möglicherweise hemmt Thyreocalcitonin kompetitiv den Angriff des PTH an der Niere; die Spezifität des phosphaturischen Thyreocalcitonineffektes ist noch nicht geklärt. Addendum. DurchRobinson et al. (1966) wurde jetzt eine Steigerung der Phosphatausscheidung unter Thyreocalcitonin beschrieben, deren Wirkungsort im Tubulusapparat vermutet wird. Die Autoren stellen mit ihren Befunden den diagnostischen Wert von Phosphaturie-Tests bei der Differentialdiagnose zwischen Hyperparathyreoidismus und Hypercalciämien anderer Ursachen (mit konsekutiver Thyreocalcitonin-Mehrsekretion?) in Frage. Unsere Ergebnisse sprechen dafür, daß die Thyreocalcitoninphosphaturie nicht sehr stark ist und höchstens an der parathormonfreien Niere zum Ausdruck kommt, daß PTH dagegen durch den Wirkstoff gehemmt wird.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745736
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  • 10
    Electronic Resource
    Electronic Resource
    Hypercalcitoninaemia in patients with pheochromocytoma (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 697-701 
    Details
    ISSN: 1432-1440
    Keywords: Calcitonin ; Phäochromocytom ; Sipple-Syndrom ; Tumor „Marker“ ; Paraneoplastische Hormonsekretion ; Calcitonin ; Pheochromocytoma ; Sipple-syndrome ; Tumor marker ; Paraneoplastic hormone secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary As pheochromocytoma sometimes is accompanied by medullary thyroid carcinoma (in the sense of multiple endocrine adonomatosis type II=Sipple-Syndrome), serum calcitonin (CT) was measured by radioimmunoassay in 4 patients with pheochromocytoma. Before extirpation of the adreno-medullary tumor, serum CT was distinctly increased to 3 and 30 ng/ml in 2 of 4 patients, respectively. After removal of the tumor, serum CT was normal in the patients and pentagastrin stimulation produced no exaggerated CT response. In hydrochloric acid extracts from the two corresponding pheochromocytoma tissues, immunoreactive-Calcitonin (IR-CT) was detected, the concentrations amounting 1 and 4 ng/mg wet tissue. These findings suggest that hypercalcitonism in patients with pheochromocytoma cannot always be ascribed to the thyroid, i.e. increased calcitonin levels do not necessarily indicate a medullary carcinoma of this organ.
    Notes: Zusammenfassung Da Phäochromocytome in Kombination mit einem medullären Schilddrüsen-Carzinom auftreten können (multiple endokrine Adenomatose Typ II=Sipple-Syndrom), wurden bei 4 Patienten mit Phäochromocytomen die Serumcalcitoninspiegel radioimmunologisch bestimmt. Bei 2 der 4 Patienten fanden sich vor Operation des Nebennierenmarktumors deutlich erhöhte Calcitoninspiegel von 3 und 30 ng/ml. Nach Entfernung des Tumors normalisierten sich die Calcitoninspiegel, ebenso erzeugte die Pentagastrin-Stimulation keinen pathologischen Anstieg des Calcitonins. In salzsauren Extrakten aus den entsprechenden beiden Phäochromocytomen fand sich radioimmunologisch bestimmbares Calcitonin; die Werte betrugen 1und 4 ng/mg Frischgewicht. Der Nachweis einer Hypercalcitoninämie bei Patienten mit Phäochromocytomen läßt daher nicht unbedingt den Schluß auf ein gleichzeitig bestehendes medulläres Schilddrüsen-Carcinom zu, da offensichtlich Nebennierenmarktumoren zu Calcitoninproduktion und -sekretion fähig sind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429104
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