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  • 1
    ISSN: 1432-0428
    Keywords: Keywords Oxidative stress ; nephropathy ; transcription factor NF-kB ; thrombomodulin ; thioctic acid.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kB activation in ex vivo isolated peripheral blood mononuclear cells. We examined 33 patients with diabetes mellitus (Type I and Type II). Patients with diabetic nephropathy showed higher NF-kB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kBp65 than patients without renal complications. NF-kB binding activity correlated with the degree of albuminuria (r = 0.316) and with thrombomodulin plasma concentrations (r = 0.33), indicative for albuminuria associated endothelial dysfunction. In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (α-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48 % and NF-kB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38 %.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Discrete & computational geometry 24 (2000), S. 325-344 
    ISSN: 1432-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. Neighborly cubical polytopes exist: for any n≥ d≥ 2r+2 , there is a cubical convex d -polytope C d n whose r -skeleton is combinatorially equivalent to that of the n -dimensional cube. This solves a problem of Babson, Billera, and Chan. Kalai conjectured that the boundary $\partial C_d^n$ of a neighborly cubical polytope C d n maximizes the f -vector among all cubical (d-1) -spheres with 2 n vertices. While we show that this is true for polytopal spheres if n≤ d+1 , we also give a counterexample for d=4 and n=6 . Further, the existence of neighborly cubical polytopes shows that the graph of the n -dimensional cube, where n\ge5 , is ``dimensionally ambiguous'' in the sense of Grünbaum. We also show that the graph of the 5 -cube is ``strongly 4 -ambiguous.'' In the special case d=4 , neighborly cubical polytopes have f 3 =(f 0 /4) log 2 (f 0 /4) vertices, so the facet—vertex ratio f 3 /f 0 is not bounded; this solves a problem of Kalai, Perles, and Stanley studied by Jockusch.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Geometriae dedicata 49 (1994), S. 143-154 
    ISSN: 1572-9168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract By ‘slanting’ symplectic quadrangles W(F) over fieldsF, we obtain very simple examples of non-classical generalized quadrangles. We determine the collineation groups of these slanted quadrangles and their groups of projectivities. No slanted quadrangle is a topological quadrangle.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of algebraic combinatorics 4 (1995), S. 145-164 
    ISSN: 1572-9192
    Keywords: Tits building ; generalized octagon ; group of projectivities ; coordinatization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We coordinatize the Moufang generalized octagons arising from the Ree groups of type 2 F 4. In this way, we obtain a very concrete and explicit description of these octagons. We use this to prove some results on suboctagons, generalized homologies, Suzuki-Tits ovoids and groups of projectivities of the Ree octagons. All our results hold for arbitrary Ree octagons, finite or not.
    Type of Medium: Electronic Resource
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