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  • 2010-2014
  • 1980-1984  (31)
  • 1965-1969  (11)
  • Life and Medical Sciences  (22)
  • Physics  (18)
  • Immunocytochemistry  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural immunocytochemical localization of fibronectin in the developing rat lung (1983)
    Springer
    Cell & tissue research 234 (1983), S. 165-177 
    Details
    ISSN: 1432-0878
    Keywords: Fibronectin ; Lung ; Development ; Ultrastructure ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a previous study changes in the macrodistribution of fibronectin during rat-lung development were examined. Using the peroxidase-antiperoxidase immunocytochemical technique, we have demonstrated the presence of fibronectin in embryonic, neonatal, and adult rat lung at the ultrastructural level. In the embryo, fibronectin is found both in an intra-and extracellular association with isolated pneumoblasts, and in a periodic distribution along the basal lamina. The neonate displays fibronectin in an intracellular association with early type-I cells and on their basal and luminal surfaces, but not in association with type-II cells. Neonatal basal lamina is diffusely labeled by anti-fibronectin antiserum. Fibronectin in adult tissue is found both intracellularly and on the basal and luminal surfaces of type-I cells but not in type-II cells. The basal lamina and interstitial connective tissue are slightly or non-reactive. These observations confirm and extend our initial suggestion that fibronectin is involved in rat-lung development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217410
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  • 2
    Electronic Resource
    Electronic Resource
    Dense bodies of the contractile system of cardiac muscle in Venus mercenaria (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 151-161 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Dense bodies in the heart muscle of Venus mercenaria exist in two forms, free and attached. Free dense bodies morphologically consist of fascicles of thin filaments in parallel array and bound together by a dense, amorphous proteinaceous material. The binding of dense bodies to the cell membrane is effected via connecting filaments of the amorphous material of the dense body which join a condensation of morphologically similar material attached to the inner osmiophilic layer of the unit membrane. This composite of dense body, connecting filaments, membrane condensation and unit cell membrane has been termed collectively the attachment plaque. The attachment plaque is part of an extensive network on the cell surface which obligates that surface to a role in the contractile process. Moreover, this set of attachment plaques imposes an organization and an orientation to most thin filaments of the cell and preserves the contractile axis of the cell.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051270203
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  • 3
    Electronic Resource
    Electronic Resource
    Light-microscopic immunocytochemical localization of fibronectin in the developing rat lung (1983)
    Springer
    Cell & tissue research 233 (1983), S. 113-123 
    Details
    ISSN: 1432-0878
    Keywords: Lung development ; Fibronectin ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of the rat lung is a process of continuing morphological change. Indications from work in other mammalian systems suggest that fibronectin may be important in the control of this process. The present study has examined embryonic, neonatal, and adult lung tissue of the rat by means of the peroxidase-antiperoxidase (PAP) technique to demonstrate fibronectin at the light-microscopic level. Positive reaction was observed with anti-fibronectin serum in all stages examined. Control sections treated with pre-immune serum or no primary serum gave negative results in each case. Fibronectin in adult tissue was localized to the alveolar surface and alveolar basal lamina. Neonatal tissue showed fibronectin on pulmonary tubule walls and in basal lamina while embryonic tissue revealed localization of the protein in the basal lamina and in association with small groups of cells at the base of septal buds. These findings suggest a role for fibronectin in the control of rat lung development. The results are discussed in terms of the known functions of fibronectin as a preliminary matrix for the subsequent deposition of collagenous connective tissue, as a cellular adhesion protein, and as surface-bound material for cellular migration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222236
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  • 4
    Electronic Resource
    Electronic Resource
    Primary photochemistry in the facultative green photosynthetic bacterium Chloroflexus aurantiacus (1983)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 22 (1983), S. 251-261 
    Details
    ISSN: 0730-2312
    Keywords: Chloroflexus aurantiacus ; primary photochemistry ; reaction centers ; bacterial reaction centers ; bacteriochlorophyll ; bacteriopheophytin ; menaquinone ; ubiquinone ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The mechanism of primary photochemistry has been investigated in purified cytoplasmic membranes and isolated reaction centers of Chloroflexus aurantiacus. Redox titrations on the cytoplasmic membranes indicate that the midpoint redox potential of P870, the primary electron donor bacteriochlorophyll, is +362 mV. An early electron acceptor, presumably menaquinone has Em 8.1 = -50 mV, and a tightly bound photooxidizable cytochrome c554 has Em 8.1 = +245 mV. The isolated reaction center has a bacteriochlorophyll to bacteriopheophytin ratio of 0.94:1. A two-quinone acceptor system is present, and is inhibited by o-phenanthroline. Picosecond transient absorption and kinetic measurements indicate the bacteriopheophytin and bacteriochlorophyll form an earlier electron acceptor complex.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240220407
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  • 5
    Electronic Resource
    Electronic Resource
    The ultrastructure of oral (buccopharyngeal) membrane formation and rupture in the chick embryo (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 197 (1980), S. 441-470 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The ultrastructure of the oral (buccopharyngeal) membrane was examined by transmission and scanning electron microscopy (SEM) from its initial formation (stage 8) to its complete disappearance (stage 20) in the chick embryo. Thinning of the oral membrane prior to rupture occurs in large measure by increased interdigitation between cells of the stomodeal ectoderm and foregut endoderm coincident with a decrease in the width of the intervening extracellular space. Large numbers of necrotic cells were not observed. Interdigitation of ectodermal and endodermal cells makes it increasingly difficult to discern two discrete epithelia, and no evidence that one germ layer disappears prior to the other was observed. Changes occurred in the fine structure of the extracellular matrix during formation and rupture of the oral membrane, and the organization of this material within the oral membrane differed from that in regions immediately lateral to it. Copious amounts of amorphous, flocculant (“lamina-like”) material are present within the oral membrane at all stages. The basal lamina of the ectoderm exhibits small loops or folds at early stages. These decrease in number as the basal lamina becomes discontinuous prior to establishment of direct intercellular contact between cells of the ectoderm and endoderm across the intervening extracellular compartment. Initial perforations of the oral membrane are preceeded by clefts between cells on both sides of this structure, and SEM observations suggest that cells of the oral membrane continue to interdigitate, elongate, and change relative positions during the rupture process.
    Additional Material: 39 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091970408
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  • 6
    Electronic Resource
    Electronic Resource
    Indirect immunofluorescent staining of fibronectin associated with the floor of the foregut during formation and rupture of the oral membrane in the chick embryo (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 198 (1980), S. 619-635 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The distribution of the glycoprotein, fibronectin, within the cranial region of stage 8-16 chick embryos was examined by indirect immunofluorescence using paraffin sections exposed to affinity-purified rabbit anti-human CIG and FITC-conjugated goat anti-rabbit immunoglobulins. Fluorescence was present within the matrix surrounding the cranial mesenchyme, along the basal surfaces of all epithelia, and surrounding the notochord at all stages. Fluorescence associated with the floor of the foregut was particularly intense. The fluorescent layers beneath the ectoderm and endoderm of the oral (oropharyngeal) membrane at stage 8 merged into a single, continuous, intensely fluorescent line as the extra-cellular space within the oral membrane narrowed during stages 9-12. This line of uniform fluorescence parallels the previously described histological reorganization of the extracellular compartment of the oral membrane, but the ultrastructural localization of this fluorescent material remains unknown. Fluorescence was also intense beneath the foregut endoderm in the presumptive cardiac region caudal to the oral membrane and was continuous with strands of fluorescent material extending into the matrix of the dorsal mesocardium and cardiac jelly of the developing tubular heart. These observations indicate that the extracellular matrix associated with the floor of the entire foregut contains fibronectin during stages encompassing the formation and rupture of the oral membrane. The presence of fibronectin within the oral membrane and dorsal mesocardium, as well as between Rathke's pouch and infundibulum and within the closing plates between ectodermal clefts and endodermal pouches, is consistent with the possibility that this glycoprotein may play a role in adhesion at these sites.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091980407
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  • 7
    Electronic Resource
    Electronic Resource
    A histological and histochemical study on the effects of adrenal cortical steroids in the fetal and neonatal rat thymusThe investigation was supported in part by USPHS Research Grant DE-00694 and a General Research Support Grant. (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 157 (1967), S. 105-115 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The late fetal and neonatal rat thymus was studied by histological and histochemical techniques following adrenal cortical steriod administration. Albino rats from seventeenth day of gestation through thirtieth postnatal day were sacrificed six, 24, 48 and 96 hours following single or series of cortisone or hydrocortisone injections in pregnant or neonatal rats. Some of gestation periods were prolonged by progesterone injections. Stains included Harris hematoxylin and eosin, May-Grünwald Giemsa, Gomori's ('52) or Burstone's ('58) method for alkaline phosphatase, and the PAS stain. Autofluorescence was examined in some of the sections.A reduction in distinctness of the cortico-medullary border of the fetal thymus followed maternal cortical steriod treatment. Similar treatment in neonatals one and two days of age led to pycnosis and phagocytosis of small lymphocytes. No histochemically stainable alkaline phosphatase was observed before sixteenth postnatal day, or following steriod administration on day one or two. However, a precocious increase in alkaline phosphatase followed a single injection on day 12. In the fetal and neonatal thymus PAS-positive material was present, was more prominent on the sixteenth day, and increased following steriod treatment, particularly on the twelfth day. Autofluorescent cells, present on the sixteenth day, increased following steriod administration. Histochemical and autofluorescent modifications were particularly prominent at the cortico-medullary border and are thought to represent postnatal maturation about the sixteenth day which changes can be induced precociously by cortical steroids.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091570202
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  • 8
    Electronic Resource
    Electronic Resource
    Vestibular projections to the nuclei of the extraocular musclesThis investigation was supported by a grant (NB-01538-06) from the Institute of Neurological Diseases and Blindness of the National Institutes of Health, Bethesda 14, Maryland. Degeneration resulting from discrete partial lesions of the vestibular nuclei in the monkey (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 118 (1966), S. 163-193 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In 35 monkeys attempts were made to produce localized unilateral lesions in individual vestibular nuclei in order to study vestibular projections to nuclei of the extraocular muscles. Portions of the medial, superior and inferior vestibular nuclei were destroyed selectively; lesions in Deiters' nucleus involved small portions of either the superior or inferior vestibular nuclei. Fiber degeneration was studied by the Nauta-Gygax technic.Exclusively ascending fibers from the superior vestibular nucleus project to ipsilateral extraocular nuclei. Ascending fibers from the inferior vestibular arise only from rostral portions of the nucleus, are not numerous and pass to all extraocular nuclei. The medial vestibular nucleus projects ascending fibers via the MLF bilaterally, asymmetrically and differentially to all extraocular nuclei. Prominent projections pass to: (a) the contralateral trochlear nucleus, and (b) the contralateral intermediate cell column and the ipsilateral ventral nucleus of the oculomotor complex. Ascending fibers from Deiters' nucleus, arising only from ventral portions of the nucleus, project primarily to: (a) the contralateral abducens and trochlear nuclei, and (b) specific asymmetrical portions of the oculomotor complex.Ascending vestibular fibers from the medial and lateral vestibular nuclei appear capable of mediating all patterned eye movements resulting from stimulation of ampullary nerves from individual semicircular canals. Vestibular projections to nuclei of the extraocular muscles are most abundant to those nuclei innervating muscles whose primary functions concern horizontal and rotatory eye movements.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001180109
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  • 9
    Electronic Resource
    Electronic Resource
    Surface architecture of the mucosal epithelium of the cat trachea: II. Structure and dynamics of the membranous portion (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 168 (1983), S. 133-144 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Bronchoscopic examination of anesthetized cats revealed that the trachea is capable of considerable change in caliber via lateral expansion of the membranous trachea. The morphological basis for this expansile capacity was determined by correlated light microscopy and scanning and transmission electron microscopy. The organization of the membranous trachea differs from that of the cartilaginous trachea. The mucosa is arranged in a series of longitudinal folds that open like an accordion when stretched laterally. These fold are not random, but appear to depend on rows of nonciliated, microvillusrich cells that form flexure lines in the surface epithelium. The mitochondria in such cell have a condensed configuration, indicating a high level of oxidative metabolism and suggesting that they may participate in transport processes that modify the luminal contents. Goblet cells, which are relatively sparse in the membranous trachea, have mitochondria in which the prominence of matrix granules and degree of mucus storage are inversely related. Mitochondrial morphology allows goblet cells that have discharged their mucin content to be readily distinguished from the microvillus-rich cells, even when their luminal surfaces lie outside the thickness of a section.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001680203
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  • 10
    Electronic Resource
    Electronic Resource
    The topographic anatomy of the muscles, nerves, and arteries of the bovine female perineum (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 119 (1966), S. 79-95 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The perineal muscles and fasciae are described and illustrated, and the diaphragma urogenitalis, components of m. sphincter urethrae, and m. ischio-cavernosus are described for the first time in the cow.The nerves of the pudendal plexus are discussed comparatively with the object of suggesting appropriate names based on their homology to the condition in other animals and man. The rami musculares to m. levator ani and m. coccygeus may originate from nn. sacrales 3 et 4, or n. pudendus, or n. rectalis caudalis. The combination of rami musculares with n. rectalis caudalis was formerly called by veterinary anatomists n. hemorrhoidalis medius, a term which should be abandoned because it is not listed in Nomina anatomica, and because it has also been applied to n. splanchnicus pelvinus in the horse. N. pudendus is large and its rami cutanei supply regio femoris caudalis as well as regio perinealis. It also gives rise to n. perinealis profundus, which supplies the genital muscles. The pudendal nerve ends by dividing into ramus mammarius and n. dorsalis clitoridis. There may be one or two nn. rectales caudales. They supply m. sphincter ani externus and adjacent parts of m. levator ani and the genital muscles.The distribution of arteria urogenitalis (vaginalis) and a. pudenda interna are described and illustrated.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001190106
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