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  • 2005-2009
  • 2000-2004  (2)
  • Juvenile  (1)
  • Key words Genital tuberculosis  (1)
  • Key words: Pulmonary hypertension—Serotonin receptor antagonist—Monocrotaline—Proliferating cell nuclear antigen.  (1)
  • 1
    ISSN: 1432-1750
    Keywords: Key words: Pulmonary hypertension—Serotonin receptor antagonist—Monocrotaline—Proliferating cell nuclear antigen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The significance of serotonin in the pathogenesis of monocrotaline-induced pulmonary hypertension (MCT-PH) in rats, plasma serotonin concentrations, and the effect of a serotonin receptor antagonist administration in association with the number of proliferative cells were investigated. The thickness of the media of the small pulmonary arteries and the weight ratio of the RV to that of LV + S (RV/[LV + S] weight ratio) were used as indices of the severity of PH. Plasma serotonin concentrations were measured by high-performance liquid chromatography. Histopathologic analysis of the lung tissue was performed by hematoxylin-eosin and elastin van Gieson staining. Immunohistopathologic staining for proliferating cell nuclear antigen (PCNA) was performed to identify proliferative cells. The severity of PH as determined by the medial thickness of the small pulmonary arteries and RV/(LV + S) weight ratio in rats with MCT-PH was significantly reduced after treatment with MCI-9042 (p 〈 0.01 and p 〈 0.05, respectively). The serotonin concentration was significantly greater in MCT-PH rats than in normal control rats (p 〈 0.05). The scores for histopathologic changes, such as thickening of the alveolar walls and interstitial inflammatory cell infiltration in MCT-PH rats, were significantly reduced after treatment with MCI-9042 (p 〈 0.05 and p 〈 0.01, respectively). The number of PCNA-positive cells was significantly greater in MCT-PH rats than in normal control rats (p 〈 0.0001) and was reduced after treatment with MCI-9042 (p 〈 0.0001). Treatment with MCI-9042 significantly inhibited the development of MCT-PH along with a decrease in the number of PCNA-positive cells, suggesting a pivotal role of serotonin in the development of PH induced by MCT.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7780
    Keywords: Key words Genital tuberculosis ; Gastrointestinal tuberculosis ; Juvenile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Genital fulminant tuberculosis is rarely a primary site of infection. We report a case of juvenile adnexal tuberculosis possibly related to tuberculosis immediately after cystectomy in the ileocecal region in a virginal girl. A 13-year-old virginal girl visited our clinic because of a huge ovarian tumor, which was resected by cystectomy. On postoperative day 39, fever episodes were noted, and she received antibiotics, which were not effective. An abscess developed in the region of the cecum and the right adnexa. Laparotomy revealed chronic abscess formation, especially in the right adnexa. Resection of the abscess was done. The pathological diagnosis was tuberculosis with caseation, although bacterial culture and molecular biological diagnosis for Mycobacterium tuberculosis were negative in sputum, vaginal discharge, urine, and stool of the patient and her family. She was placed on anti-tuberculosis drugs, including isoniazid, rifampicin, and ethambutol, and this regimen was effective. This patient represents a rare case of fulminant adnexal tuberculosis without pulmonary disease.
    Type of Medium: Electronic Resource
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