Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Total synthesis of (+)-pseudomonic acid C (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 3916-3918 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00370a040
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Investigation of magnetic reconnection during a sawtooth crash in a high-temperature tokamak plasma (1994)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 1 (1994), S. 3269-3276 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper a laboratory investigation is made on magnetic reconnection in high-temperature Tokamak Fusion Test Reactor (TFTR) plasmas [Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 51]. The motional Stark effect (MSE) diagnostic is employed to measure the pitch angle profile of magnetic field lines, and hence the q profile. An analytical expression that relates pitch angle to q profile is presented for a toroidal plasma with circular cross section. During the crash phase of sawtooth oscillations in plasma discharges, the ECE (electron cyclotron emission) diagnostic measures a fast flattening of the two-dimensional (2-D) electron temperature profile in a poloidal plane, an observation consistent with the Kadomtsev reconnection theory. On the other hand, the MSE measurements indicate that central q values do not relax to unity after the crash, but increase only by 5%–15%, typically from 0.7 to 0.8. The latter result is in contradiction with the 2-D models of Kadomtsev and/or Wesson. In the present study this puzzle is addressed by a simultaneous analysis of electron temperature and q profile evolutions. Based on a heuristic model for magnetic reconnection during the sawtooth crash, the small change of q, i.e., partial reconnection, is attributed to the precipitous drop of pressure gradients that drive the instability and the reconnection process, as well as flux conserving plasma dynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.870479
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Increased Smad4-Mediated Acceleration of TGF-β1 Signaling and Myofibroblastic Differentiation in Tubulointerstitial Cells in Kidneys of Hereditary Nephrotic Mice (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: ICR-derived glomerulonephritis (ICGN) mouse is a hereditary model animal for nephrotic syndrome with chronic renal tubulointerstitial fibrosis. In fibrotic disorder, myofibroblastic differentiation plays crucial roles in pathogenesis and is dominantly regulated by the transforming growth factor-beta1 (TGF-β1) signaling system. To reveal the relationships between the pathogenic mechanism of the renal fibrosis and TGF-β1 signaling in ICGN mice, we examined the expression and localization of TGF-β1 signal transducer proteins, TGF-β receptor (TGFR)-I, TGFR-II, Smad2/3 and Smad4, in kidney sections and in primarily cultured renal tubulointerstitial fibroblasts (TIFs). In kidneys of ICGN mice, many TIFs were differentiated to myofibroblastic cells, confirmed as alpha-smooth muscle actin (αSMA)-positive cells, and though no significant increase in production and activation of TGF-β1 were observed in ICGN-TIFs as compared with control ICR-TIFs. The rate of αSMA positive cells in ICGN-TIFs increased during cell culture but not in those of ICR-TIFs. In vitro transcriptional reporter assay for TGF-β1 and Western blotting for TGF-β1 signal transducers revealed that no notable differences in the expression levels of TGFR-I, TGFR-II or Smad2/3 were seen between ICR- and ICGN-TIFs. However, augmented cytoplasmic Smad4 in ICGN-TIFs was observed, and it may cause hypersensitivity against TGF-β1. These results indicate that abnormal cytoplasmic augmentation of Smad4 induces acceleration of TGF-β1 signaling and fibrogenic myofibroblastic differentiation in the renal tubulointerstitial cells of ICGN mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130117k.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    European Tissue Repair Society Focus Meeting
Tissue Repair, Contraction, and the Myofibroblast
Nyon, Switzerland
November 18–20, 2004
The following compilation of abstracts represents a partial list of submissions received for presentation at the meeting. Please note the abstracts are arranged in alphabetical order (by presenter's name). Communications by the invited speakers will be published in a book by Landes Bioscience.: TGF-β1 Signaling is Regulated by Negative Feedback Mechanism of BMP-7 in Fibrotic Kidneys of Hereditary Nephrotic Mice (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: ICR-derived strain with gulomerulonephrisis (ICGN) mouse derived from ICR mouse is a newly established mouse strain with hereditary nephrotic syndrome. The affected ICGN mice consistently show the clinical signs of nephrotic syndrome, developing various degrees. The lesions consist of thickened capillary basement membrane, enlarged mesangium without cellular proliferation, and tubulointerstitial fibrosis. Based on these histopathological findings and clinical biochemical data, ICGN strain mouse is considered to be a good experimental model for human idiopathic nephrotic syndrome. Extracellular matrix (ECM) components provide structural integrity to the tissues, and mediate regulation of cell growth, migration, differentiation, etc. The damaged cells have increased secretion of ECM components. This is a kind of self-protecting reaction that is associated with healing process against injury. However, the hyperaccumulation of ECM components leads to fibrosis, a pathological phenomenon. Therefore, it is very important to make clearly the process of fibrosis in ICGN strain mouse. In this study, the expression and localization of transforming growth factor beta1 (TGF-β1), TGF-β1 type I receptor (TGFR1), and bone morphogenic protein (BMP)-7, which regulate the signals of TGF-β1 negatively, were investigated by using immunohistochemical staining and Western blotting. High expression levels of TGF-β1 and TGFR1 were observed in tubular epithelial cells of middle stage-ICGN mice as compared with those of control ICR mice. BMP-7 was strongly expressed in tubular epithelium of ICR mice, but it decreased with the progression of renal disease in ICGN mice. Moreover, no localization of BMP-7 in expanded tubular epithelial cells in ICGN mice was seen. These data suggest that the increase of TGF-β1 and TGFR1 and the degradation of negative regulation of TGF-β1 by BMP-7 in middle and late stages of ICGN mice play an important role in renal fibrosis of ICGN mice. The present findings may contribute to elucidate the pathogenic mechanisms of human idiopathic nephrotic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130117a.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Spatial and angular distribution of light incident on coatings using Mie-scattering Monte Carlo simulations (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of cosmetic science 27 (2005), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We show the results of Mie-scattering Monte Carlo models developed to simulate the optical properties of light incident on particle-containing coatings. The model accommodates mixtures of particles with different sizes and complex refractive indices, enabling the simulation of formulations, including pigments. The simulation tracks trajectories of photons as they propagate through the turbid medium, calculating both angular and spatial light intensity distributions. Scalar quantities such as total transmission and reflection, and haze and diffuse reflectance, are also calculated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-2494.2005.00289_5.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    First-order quasi-phase matched LiNbO3 waveguide periodically poled by applying an external field for efficient blue second-harmonic generation (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 435-436 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A novel method of fabricating a periodic domain structure with ideal laminar domains in LiNbO3 by applying an external field at room temperature is proposed. The method allows a high blue beam power of 20.7 mW and a high conversion efficiency of 600%/W cm2 to be obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.108925
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Asymmetric synthesis via axially dissymmetric molecules. 7. Synthetic applications of the enantioselective reduction by binaphthol-modified lithium aluminum hydride reagents (1984)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 6717-6725 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00334a042
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Global magnetic fluctuations in spheromak plasmas and relaxation toward a minimum-energy state (1985)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 28 (1985), S. 3667-3675 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Globally coherent modes have been observed during formation in the S-1 Spheromak plasma [Plasma Physics and Controlled Nuclear Fusion 1984 (IAEA, Vienna, Austria, 1985), Vol. 2, p. 535] by analysis of magnetic field fluctuations measured from outside the plasma. The modes are of low n number (2≤n≤5), where n is defined by the functional dependence einφ of the fluctuation on toroidal angle φ. These modes are shown to be related to flux conversion and plasma relaxation toward a minimum-energy state during the spheromak formation. The modes are active while the q profile is rapidly changing, with q on axis, q0, rising to 0.7. A significant finding is the temporal progression through the n=5, 4, 3, 2; m=1 mode sequence as q rises through rational fractions m/n. During formation, peak amplitudes of the n=2, 3, 4 modes relative to the unperturbed field have been observed as high as 20%, while more typical amplitudes are below 5%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.865321
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Sawtooth stabilization by electron cyclotron heating at the q=1 surface in the WT-3 tokamak (1991)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 2200-2204 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Sawtooth oscillations (STO) in the Ohmically heated (OH) WT-3 tokamak [Plasma Physics and Controlled Nuclear Fusion Research 1988 (IAEA, Vienna, 1989), Vol. 1, p. 563] are strongly modified or suppressed by localized electron cyclotron resonance heating (ECH) near the q=1 surface, where q refers to the safety factor. The effect of ECH is much stronger when it is applied on the high-field side, as compared to the low-field side. Complete suppression of the STO is achieved for the duration of the ECH when it is applied on the high-field side, in a low-density plasma, provided the ECH power exceeds a threshold value. This threshold decreases with the increasing safety factor at the limiter qL and the complete stabilization of STO can be obtained even when ECH is applied on the low-field side in the high-qL region. It is noticeable that these complete stabilizations can be obtained only by the localized ECH with the elliptic antenna. The STO stabilization is attributed to a modification of the current density profile by high-energy electrons generated by ECH, which reduces the shear in the q=1 region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859636
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Experimental investigation of three-dimensional magnetic reconnection by use of two colliding spheromaks (1993)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 5 (1993), S. 3691-3701 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Experimental investigation of three-dimensional (3-D) effects of magnetic reconnection dynamics has been extended by use of axially colliding spheromaks [M. Yamada et al., Phys. Fluids B 3, 2379 (1991)]. The two toroidal shape spheromak plasmas with major radii of 15–20 cm and with parallel toroidal currents of up to 30 kA collide to merge in an external equilibrium field. It is important to note that the present experimental setup allows one to investigate magnetic reconnection comprehensively from both local and global points of view. Reconnection angle θ between the merging field lines is varied by changing the polarity of the internal toroidal field and the magnitude of an external toroidal field. It is observed that the speed of counterhelicity merging with θ∼180° is about three times faster than that of cohelicity merging with θ∼90°. This suggests the significance of a 3-D effect on the reconnection process. This difference is attributed to the property of the neutral current sheets with and without the magnetic field component parallel to the reconnection (X) line. In the counterhelicity merging, the neutral current sheet is compressed in much shorter time than in the cohelicity merging, resulting in much higher current density and subsequent faster decay of the current sheet. This induces a faster magnetic reconnection. The reconnection speed increases proportionally with the initial approaching speed of the spheromaks, suggesting that a compressible driven reconnection model is consistent with the present reconnection experimental results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.860840
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...