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  • 1
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Active, passive, and hybrid mode locking of a monolithic extended-cavity semiconductor laser with an integrated saturable absorber have been demonstrated. Actively mode locked at a repetition rate of 8.6 GHz, 6.2 ps pulses were measured. Hybrid mode locking resulted in 4.4 ps pulses. The extended-cavity laser also exhibits self-starting passive mode locking at a repetition rate of 8.57 GHz with 5.5 ps pulses. A broad spectrum allows wavelength selectivity over a range of 15 nm with little change in the pulse width.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 42 (1992), S. 537-597 
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 11 (2005), S. 0 
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Joint haemorrhage and subsequent haemophilic arthropathy are significant complications in haemophilia. The pathophysiology involves inflammation and angiogenesis. Cyclooxygenase-2 (COX-2) inhibitors are anti-inflammatory agents, which have potent anti-inflammatory, anti-angiogenic and analgesic properties yet do not affect platelet function in the manner of traditional non-steroidal anti-inflammatory drugs. These properties make such agents potentially useful as adjunctive therapy in haemophilia. There is only one prior report describing rofecoxib treatment in a single haemophilia patient. Our objectives were to determine the safety and efficacy of rofecoxib in treating acute haemarthrosis, chronic synovitis, target joints and pain. We conducted a retrospective medical record review of patients treated with rofecoxib for acute haemarthrosis, chronic synovitis, target joint or pain. The safety and efficacy of rofecoxib treatment were determined based on subjective patient reports and physical examinations during follow-up clinic visits. A total of 28 patients between 3 and 37 years of age were treated for a total of 42 courses of rofecoxib treatment. All courses were evaluated for safety and 31 for efficacy. Rofecoxib was used for eight acute haemarthrosis, four target joints, seven cases of synovitis and 12 episodes of pain. Efficacy was demonstrated particularly for chronic synovitis and pain and no serious adverse events occurred. This is the largest study to date evaluating COX-2 inhibitors as adjunctive therapy in haemophilia and suggests that these agents may be an important adjunctive therapy in the management of haemophilia.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 11 (2005), S. 0 
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Prevention of bleeding, especially into joints, with prophylactic factor infusions is the most effective treatment for severe haemophilia patients. Approximately 15–30% of patients with factor VIII deficiency and 3–5% of patients with factor IX deficiency develop neutralizing antibodies (inhibitors) to factor precluding their use. Such patients often have significant bleeding complications including life- and limb-threatening bleeds and severe joint disease. Prophylaxis for such patients is not generally considered because of the fact that the standard (bypassing) agents for such patients are not as effective as natural factor replacement, because of concerns for thrombotic complications and also because of the very high cost of bypassing agents. We treated two patients with high titre inhibitors with prophylactic recombinant factor VIIa (rFVIIa). The first patient was treated as a result of development of a target joint and to reduce the use of agents that can lead to anamnesis of his inhibitor. The second patient had multiple severe bleeds and was hospitalized 20% of the time over a 2-year period. He had a very poor quality of life. Both patients had shown good responses previously to rFVIIa for treatment of bleeds. Both patients had an outstanding response to prophylaxis albeit at a very high cost. Prophylaxis with rFVIIa can be an effective approach in select inhibitor patients with severe complications related to bleeding.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Summer mortality (’die-off‘) is common in striped bass, Morone saxatilis (Walbaum), in the San Francisco Bay-Delta region. Tissue and blood samples of moribund and healthy striped bass collected during the summers of 1986–1988 were analysed. Sixteen moribund and 25 healthy reference fish from the Carquinez Strait area and eight fish caught in the Pacific Ocean were studied. Moribund fish plasma was invariably yellow-orange; most of the moribund fish had discoloured livers with haemorrhagic regions, and approximately one-third had haemorrhagic intestines. Piasma levels of aspartale aminotransferase, uric acid, alkaline phosphatase and cortisol were significantly higher than in reference fish from Carquinez Strait and the Pacific Ocean, whereas cholesterol, sodium, chloride, triiodothyronine and glucose levels were significantly lower. Hepatic heavy metal concentrations and bacterial content were similar in moribund and reference fish. Gill Na.+, K+ -ATPase activity was significantly lower in moribund fish. Liver, kidney, intestine, and thyroid follicles of moribund fish displayed various histopathological changes, and corticosteroidogenic (interrenal) tissue could not be identified positively in moribund fish. These findings are discussed in relation to recent work on the chemical burdens (industrial and agricultural hydrocarbons) found in livers from some of the fish examined in this study.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 6 (1992), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of Helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an Ussing chamber technique. Luminal addition of H. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with E. coil lipopolysaccharide. Electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 4 (1990), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of duodenal ulcer healing on the acid secretory responses to modified sham feeding and maximal pentagastrin stimulation has been studied in 17 patients treated successfully with ranitidine (n= 9) and sucralfate (n= 8). Parietal cell sensitivity was calculated as the ratio of the modified sham feeding response to the peak pentagastrin response, expressed as a percentage. Ulcer healing after sucralfate therapy resulted in significant falls in modified sham feeding stimulated acid output (P 〈 0.02), from 9.4 (1.8–17.0) (median + range) to 3.7 (0.2–9.4) mmol/h; in peak acid output (P 〈 0.05) from 42.8 (23.0–61.4) to 27.7 (7.2–51.0)mmol/h; and in the parietal cell sensitivity (P 〈 0.05) from 19.2 (4.4–42.6) to 14.3 (2.8–19.7)%. No significant falls in any of these parameters were noted following ulcer healing with ranitidine. Duodenal ulcer healing with sucralfate results in decreased acid secretory responses to vagal and pentagastrin stimulation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Amino acids 1 (1991), S. 183-192 
    ISSN: 1438-2199
    Keywords: Amino acids ; Kidney ; Nutrition ; Phenylalanine ; Tyrosine ; Uraemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney has an important role in the metabolism of amino acids and control of plasma concentrations. Reabsorption by the tubules recovers about 70g/day of amino acids, derived from both the diet and metabolism in other tissues. Amino acids regulate haemodynamics and proteolysis and maintain integrity of the kidney. Abnormal plasma and muscle amino acid profiles in chronic renal failure (i.e. low essentials and tyrosine with high nonessentials) first indicated malnutrition, which can be partially corrected by supplementation. The loss of effective kidney tissue and uraemia, in addition to nutrition, have been considered in studies of phenylalanine hydroxylation used to investigate low tyrosine. Investigations in normal kidney have shown that glutamine uptake maintains acid-base homeostasis, glycine and citrulline are removed, and serine and arginine are released into the circulation. These metabolic processes are impaired in chronic renal failure. Uraemia affects most tissues and causes malnutrition, whilst acidosis activates catabolism of amino acids and proteins in muscle. Hyperinsulinaemia probably depresses plasma branchedchain amino acids and particularly valine. These abnormalities are less likely to respond to dietary supplementation.
    Type of Medium: Electronic Resource
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