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  • 1
    Electronic Resource
    Electronic Resource
    Dopaminergic regulation of striatal cholinergic interneurons: an in vivo microdialysis study (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 523-527 
    Details
    ISSN: 1432-1912
    Keywords: Acetylcholine ; Choline ; Dopaminergic agents ; Microdialysis ; Rat ; Striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vivo microdialysis was used to study the putative inhibitory effects of dopamine on cholinergic interneurons in the striatum of conscious rats. The dopamine receptor agonists apomorphine (0.3 and 3 mg/kg, s.c.) and (±)N-0437 (1.4 mg/kg, s.c.) decreased interstitial concentrations of acetylcholine while increasing those of choline. In contrast, the dopamine receptor antagonists haloperidol (0.1 and 1 mg/kg, i.p.) and (±)sulpiride (20 mg/kg, i.p.) enhanced striatal acetylcholine output but had little effect on choline. Previously, a lack of effect of these drugs on striatal acetylcholine was reported. The main methodological difference between these studies was that the calcium concentration of the microdialysis perfusion solution was 3.4 mM in the former study versus 1.2 mM in the present experiments. The results of this study reemphasize the importance of the calcium concentration in determining the effects of drugs on central neurotransmitter release, and confirm a role of dopamine in the regulation of striatal cholinergic interneurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169040
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 345 (1992), S. 144-152 
    Details
    ISSN: 1432-1912
    Keywords: Acetylcholine release ; Dopamine release ; Microdialysis ; Striatum ; D-1 and D-2 dopamine receptors ; Post-implantation interval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of intrastriatal application of D-1, D-2 and indirect dopaminergic drugs on the release of striatal acetylcholine as a function of the post-implantation intervals was studied using in vivo microdialysis. The dopamine, D-2 agonists LY 171555 and (−)N0437 inhibited the release of striatal acetylcholine to 40% of control values 16–24 h after implantation of the dialysis cannula. When LY 171555 was infused 40–48 h after implantation of the dialysis cannula, the response was attenuated to 20% of control values. Meanwhile, the effectiveness of infusions of the antagonists (−)sulpiride and haloperidol was augmented from a non significant effect at 16–24 h to a 150% increase 40–48 h after implantation of the cannula. Infusions of the dopamine releasing agent amphetamine or the dopamine uptake inhibitor nomifensine resulted in a dose-dependent increase in the overflow of dopamine. Not until a sevenfold increase in the level of dopamine was seen, the release of acetylcholine was significantly affected. This hyporesponsiveness of the striatal cholinergic interneurons to endogenous dopamine could not be attributed to dopamine D-1 receptor activation, since no effects on striatal acetylcholine release were found by intrastriatal infusions of the selective D-1 agonist CY 208-243 or the selective D-1 antagonist SCH 23390. The results indicate that dopamine D-2 receptors are involved in the regulation of striatal acetylcholine release and that these receptors are tonically occupied by endogenous dopamine under the present experimental conditions 40–48 h after probe implantation. The fact that cholinergic responses to intrastriatally applied dopaminergic agents are dynamic with respect to the time between implantation surgery of the dialysis tube and the experimental measurements suggests that the striatal neuronal system is perturbated by the implantation of a dialysis probe for a considerable length of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165729
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    Paper (German National Licenses)
    Fulltext
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