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  • 2005-2009
  • 1985-1989  (2)
  • 1980-1984
  • Benzophenone, Massenspektrometrie  (1)
  • Cerebral ischemia  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Positive and negative ion mass spectrometry of benzophenones, the acid-hydrolysis products of benzodiazepines (1987)
    Springer
    International journal of legal medicine 98 (1987), S. 1-10 
    Details
    ISSN: 1437-1596
    Keywords: Benzophenones, mass spectrometry ; Mass spectrometry, negative ion chemical ionization ; Benzodiazepines, mass spectrometry ; Benzophenone, Massenspektrometrie ; Massenspektrometrie, Benzophenone ; Benzodiazepine, Massenspektrometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es werden positive Elektronenstoß-(EI)-, positive chemische Ionisierungs-(CI)- und negative CI-Massenspektren von Benzophenonderivaten beschrieben. Beim positiven EI-Modus wurden bei fast allen Verbindungen intensive Molekülpeaks beobachtet; andere Peaks entstehen durch Spaltungsreaktionen beiderseits der Carbonylgruppe. Beim positiven CI-Modus erschienen quasi-molekulare Ionen [M+1]+ zusammen mit [M+C2H5]-Peaks bei fast allen Verbindungen; einige Fragmentierungsionen entsprachen denen des positiven EI-Modus. Beim negativen CI-Modus waren die Spektren viel einfacher als beim positiven EI- oder CI-Modus. Im Falle des 1 Torr negativen CI-Modus zeigten einige Spektren lediglich einzelne Molekül-Anionen; beim 0,01 Torr negativen CI-Modus erschienen Halogen-oder Nitro-Peaks zusätzlich zu den Molekül-Anionen. Weiterhin wird ein Extraktionsverfahren zur Isolierung der Benzophenone aus Urin und Plasma nach stark saurer Hydrolyse beschrieben sowie die Trennung mittels Gas-Chromatographie (GC) als Vorbereitung zur Identifizierung durch GC/Massenspektrometrie.
    Notes: Summary Positive electron impact (EI), positive chemical ionization (CI), and negative CI mass spectra of 14 benzophenones are presented. In the positive EI mode, intense molecular peaks appeared for most compounds; some other peaks due to splitting at both sides of the carbonyl group also appeared. In the positive CI mode, [M+1]+ quasi-molecular ions together with [M+C2H5]+ peaks were observed for all compounds; some fragment peaks were common to those in the positive EI mode. In the negative CI mode, the spectra were much simpler than those in the positive EI or CI mode. In the 1 Torr negative CI mode, some spectra showed only single molecular anions; in the 0.01 Torr negative CI mode, halogen or nitro peaks appeared in addition to the molecular anions. An extraction procedure for benzophenones from human urine and plasma after heating in strong acid, and their separation by gas chromatography (GC) are also presented to serve for their actual identification by GC/mass spectrometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200380
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphological studies on cerebral cortical lesions induced by transient ischemia in Mongolian gerbil —Diffuse and peripheral pallor of the neuronal perikarya (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 1-8 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Ischemic neuronal injury ; Long-term recovery ; Mongolian gerbil ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unilateral transient cerebral ischemia was produced in Mongolian gerbils by clipping the left common carotid artery for 1h. About 60% of the gerbils with neurological symptoms had post-ischemic seizures. The majority of those that had seizures died within a few days, and sections of their cerebral cortices contained many dark and shrunken neurons. However, the gerbils that did not have seizures survived without any severe complications. In the cerebral cortex of the latter, the neurons with diffuse or peripheral pallor of the perikarya were seen along with a small number of dark and shrunken neurons. Diffuse pallor occurred within a few hours following ischemia in layers III, V and VI, and disappeared 1 or 2 days after recirculation. Electron microscopically, these neurons showed dispersion of ribosomes, simple and elongated profiles of rough endoplasmic reticulum (r-ER), clustered vacuoles, and mild to moderate mitochondrial swelling. Occasional net-like tubulomembranous structures, probably derived from r-ER, were observed. On the other hand, peripheral pallor became apparent after 5 days following ischemia, usually involving layer II first and gradually extending to the deeper layers. Concomitantly, the amount of neuropil decreased and the dendrites exhibited tortuosity and irregularity in layer II. Electron microscopically, these neurons showed marked swelling of peripheral perikarya and polyribosomes and organelles were located peripherally to the nuclei. In addition, numerous degenerated axon terminals and distended dendrites were observed around the neurons. These observations indicate that diffuse pallor represents damage directly induced by ischemia and subsequent recirculation, while peripheral pallor is the delayed and remote effect of ischemia, probably due to degeneration of neuronal processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687395
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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