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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Lymphomatous polyposis (LP) is considered to represent mantle cell lymphoma (MCL) of the gastrointestinal (GI) tract. However, a few reports have suggested that some are follicular lymphoma (FL) or mucosa-associated lymphoid tissue (MALT) lymphomas. In this study, we analysed 35 patients and clarified the clinicopathological features of LP.Methods and results:  Paraffin-embedded tissue samples were stained immunohistochemically and analysed by tissue-fluorescence in situ hybridization (T-FISH) for IGH/CCND1 (cyclin D1) and IGH/BCL2. The average age of the patients was 58.3 years. Over half of the cases showed gastric, duodenal, small intestinal, ileocaecal and sigmoid colonic lesions (15, 19, 15, 16 and 16 cases, respectively). Phenotypically, cases were classified into three types of MCL (cyclin D1+ CD5+ CD10–) (n = 12), FL (cyclin D1– CD5– CD10+) (n = 14) and MALT (cyclin D1– CD5– CD10–) (n = 9). T-FISH identified 11 of the 11 examined cases with MCLs to have IGH/CCND1, while seven of 10 cases with FL had IGH/BCL2, and none of the MALT cases were positive for IGH/CCND1 or IGH/BCL2. At the study endpoint, five of 12 patients with MCL were dead, two of 14 with FL and one of nine with MALT were dead of other disease. Event-free survival analysis showed significantly poorest outcome in MCL, followed by FL, while MALT was associated with a favourable outcome (P = 0.0040).Conclusions:  Our study emphasizes the importance of differentiating MCL, FL and MALT of LP in evaluating prognosis and hence the most suitable therapeutic regimen.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Other than ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, the molecular mechanisms underlying gastric and intestinal phenotypes of human stomach adenocarcinomas have yet to be clarified in detail. We have reported that Sox2, an HMG-box gastric transcription factor, is expressed in normal gastric mucosa and down-regulated in intestinal metaplasia.Methods and results:  We analysed mRNA levels of Sox2 and other differentiation markers in 50 surgically resected stomach adenocarcinomas, immunohistochemically classified into gastric (G), gastric-and-intestinal (GI)-mixed, solely intestinal (I), and null (N) types. Sox2 was found to be transcribed in G and GI-mixed type adenocarcinomas in accordance with MUC5AC and MUC6 expression, while Cdx1 and Cdx2 were up-regulated in GI-mixed and I types along with the expression of MUC2 and villin. In the N type, both gastric and intestinal transcription factors were suppressed. Immunohistochemistry confirmed expression of Sox2 in MUC5AC+ lesions and Cdx2 localization together with MUC2. A stomach adenocarcinoma cell line, KATOIII, demonstrated both MUC5AC and Sox2, although MUC5AC mRNA was not detected in the Sox2+ AGS cell line.Conclusions:  Sox2 may play an important role in maintaining a gastric phenotype in stomach cancers as well as in normal tissue, in cooperation with other cofactor(s).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 53 (1988), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Thirty-eight California and French wines were analyzed for γ-nonalactone by Freon extraction and gas chromatography. The California white wines had from 0 to 16 pg/L (average for 6 samples was 7 μg/L and the red wines from 12 to 43 μg/L (average for 20 samples was 24 μgL). French red wines obtained similar amounts, 14 to 41 μgL (average for 12 samples was 21 μgL). The sensory threshold for γ-nonalaconte was determined to be 30 μg/L.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 875-875 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have succeeded in simplifying and improving the procedure of Grassmann and Hiibner merely by making use of ordinary paper electrophoresis. The substances to be tested are applied not as spots but as streaks drawn obliquely to each other (crossed or not crossed). The angle between the streaks ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 638-639 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Objections3 were raised, namely, that the formation of enzyme-substrate complex was not demonstrated thereby but merely an overlapping of the line of enzyme and that of substrate appeared, that the enzyme did not interact with substrate but with its split products and so on. We have already ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1386-1387 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die i.v. Injektion von Kohlepartikeln an Mäusen, 24 h vor einer Bestrahlung mit 600 R, bietet einen bemerkenswerten Strahlenschutz. Die Problematik der biologischen Schutzfunktion durch die Reticulo-histiocytäre Systemblockade wird diskutiert.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-1596
    Keywords: Bloodstains, species identification ; Enzyme-linked immunosorbent assay (ELISA), spezies identification ; Species identification, ELISA ; Immunabsorptionstest (ELISA), Speziesdifferenzierung in Blutspuren ; Blutspuren, Speziesdifferenzierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Ein enzymgekoppelter Immunabsorptions-Test (ELISA) für die Speziesidentifizierung menschlicher Blutspuren unter Verwendung zweier kommerzieller Anti-Seren gegen menschliches Serum wird beschrieben. Menschliche Blutspuren waren unterscheidbar von solchen des Schimpansen und solchen anderer Tiere unter Verwendung von Rohseren, und die Differenzierung zwischen Mensch und Schimpanse wurde eindeutiger, wenn diese Anti-Seren mit einer kleinen Menge von Schimpansenplasma absorbiert wurden. Menschliche Blutspuren konnten durch die gezeigte Methode klar identifiziert werden, dies sogar nach vierwöchiger Lagerung bei Raumtemperatur.
    Notes: Summary An enzyme-linked immunosorbent assay (ELISA) for species identification of human bloodstains using two commercially available antisera against human serum is described. Human bloodstains were to be distinguished from those of chimpanzees and other animals using raw antisera, and the differentiation between human and chimpanzee became more evident when those antisera were absorbed with a small amount of chimpanzee plasma. Human bloodstains could clearly be identified by the present method even after 4 weeks of aging at room temperature.
    Type of Medium: Electronic Resource
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  • 8
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    Unknown
    Wien : Periodicals Archive Online (PAO)
    Journal of economics/Zeitschrift für Nazionalökonomie. 49 (1989) 322 
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 15-18 (Jan. 1987), p. 605-610 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 302-303 (Jan. 2006), p. 235-241 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To investigate the strength efficiency of fly ash in concrete, the contribution of fly ash to strength, k value was calculated with the equation: the strength difference between fly ash concrete and control concrete with no fly ash due to the different fly ash content divides by the strength difference between both control concrete with no fly ash due to the different cement content which equals to the former different fly ash content. The k values were organized with fly ash specific surface area, concrete curing condition and age of specimens. Based on a large number of datacollected from several proceedings and journals published in Japan during 1981 to 2003, the influences of fly ash property, mixture proportion and curing condition on k value were investigated. Within the range of study the following observations were made: (1) When fly ash concrete kept in moist curing, the k value of fly ash with specific surface area from 250 to 500 m2/kg is averagely 0.5 to 0.6 or higher at an age of 91 days and later, whereas that of fly ash with specific surface area from150 to 250 m2/kg is around 0.4 to 0.5, and with some cases contributing little to the strength. (2) In the range of a portland cement content of 250 to 450 kg/m3, the strength contribution tends to increase as the cement content increases. (3) The contributions of fly ash to strength at 91 and 364 days are 1.44 to 1.97 times as large as those at 28 days, respectively, by standard curing, but conversely decrease to 0.75 to 0.79 times those at 28 days by air curing
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