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  • 2005-2009  (1)
  • 1980-1984  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    [3H]Choline Uptake and Metabolism in Nonsynaptic Regions of a Crustacean Sensory Nerve (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 36 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The posterior stomach nerve (PSN) is a crustacean sensory nerve containing about 60 cholinergic neurons, which are devoid of synaptic interactions. Kinetic analysis shows that the PSN takes up [3H]choline by both low-affinity (Km= 163 μM) and high-affinity (Na+-dependent) (Km= 1 μM) processes. The capacity of the high-affinity system is only about 1% that of the low-affinity system. The high-affinity system is not tightly coupled to acetylcholine (ACh) synthesis, and it appears that both ACh and phosphorylcholine are formed from an intracellular pool of choline, which is fed by both uptake systems. There are differences in the rates of [3H]choline uptake and 3H metabolite accumulation between regions of the PSN that contain neuronal cell bodies and those that do not. These differences may arise from differences in the relative proportion of neuronal to nonneuronal tissue in each nerve region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb00415.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A stepwise mechanism for acetylcholine receptor channel gating (2007)
    [s.l.] : Nature Publishing Group
    Nature 446 (2007), S. 930-933 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Muscle contraction is triggered by the opening of acetylcholine receptors at the vertebrate nerve–muscle synapse. The M2 helix of this allosteric membrane protein lines the channel, and contains a ‘gate’ that regulates the flow of ions through the pore. We used ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05721
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    Paper (German National Licenses)
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