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  • 1
    Electronic Resource
    Electronic Resource
    A stepwise mechanism for acetylcholine receptor channel gating (2007)
    [s.l.] : Nature Publishing Group
    Nature 446 (2007), S. 930-933 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Muscle contraction is triggered by the opening of acetylcholine receptors at the vertebrate nerve–muscle synapse. The M2 helix of this allosteric membrane protein lines the channel, and contains a ‘gate’ that regulates the flow of ions through the pore. We used ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05721
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  • 2
    Electronic Resource
    Electronic Resource
    Reaction mechanism determines NMDA receptor response to repetitive stimulation (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 430 (2004), S. 790-793 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] At central excitatory synapses, N-methyl-d-aspartate (NMDA) receptors, which have a high affinity for glutamate, produce a slowly rising synaptic current in response to a single transmitter pulse and an additional current after a second, closely timed stimulus. Here we show, by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature02775
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  • 3
    Electronic Resource
    Electronic Resource
    Mapping the conformational wave of acetylcholine receptor channel gating (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 403 (2000), S. 773-776 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Allosteric transitions allow fast regulation of protein function in living systems. Even though the end points of such conformational changes are known for many proteins, the characteristics of the paths connecting these states remain largely unexplored. Rate-equilibrium linear free-energy ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35001586
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  • 4
    Electronic Resource
    Electronic Resource
    [3H]Choline Uptake and Metabolism in Nonsynaptic Regions of a Crustacean Sensory Nerve (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 36 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The posterior stomach nerve (PSN) is a crustacean sensory nerve containing about 60 cholinergic neurons, which are devoid of synaptic interactions. Kinetic analysis shows that the PSN takes up [3H]choline by both low-affinity (Km= 163 μM) and high-affinity (Na+-dependent) (Km= 1 μM) processes. The capacity of the high-affinity system is only about 1% that of the low-affinity system. The high-affinity system is not tightly coupled to acetylcholine (ACh) synthesis, and it appears that both ACh and phosphorylcholine are formed from an intracellular pool of choline, which is fed by both uptake systems. There are differences in the rates of [3H]choline uptake and 3H metabolite accumulation between regions of the PSN that contain neuronal cell bodies and those that do not. These differences may arise from differences in the relative proportion of neuronal to nonneuronal tissue in each nerve region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb00415.x
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple forms of mechanosensitive ion channels in osteoblast-like cells (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 646-651 
    Details
    ISSN: 1432-2013
    Keywords: Osteoblasts ; Ion channels ; Mechanotransduction ; Stretch-activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patch-clamp recording techniques were used to examine the direct effects of mechanical stimulation on ion channel activity in human osteoblast-like osteosarcoma cells. Three classes of mechanosensitive ion channels were present and could be distinguished on the basis of conductance, ionic selectivity, and sensitivity to membrane tension. The largest conductance channel (160 pS) was K+-selective and showed both a decrease in long closed interval duration and an increase in burst length with increasing membrane tension. For low applied pressures, there was an e-fold increase in the probability of this channel being open (P open) for every 3.4 cm2 Hg change in pressure. Two additional pressure-dependent channels had smaller conductances, i.e., 60 pS and 20 pS; the 60 pS channel appeared to be non-selective for cations. We propose that one or more of these mechano-sensitive channels is involved in the response of bone to mechanical loading.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370609
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