Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2005-2009
  • 1970-1974  (2)
  • 1955-1959
  • 1935-1939
  • Oxygen Consumption  (1)
  • Respiration  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 30 (1973), S. 161-174 
    ISSN: 1432-0738
    Keywords: Atropine ; N-Methylatropine ; Phrenic Nerve ; Respiration ; Atmung ; Atropin ; N-Methylatropin ; N. phrenicus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 78 narkotisierten, bivagotomierten Ratten wurde die Entladungsfrequenz inspirationsaktiver Einzelfasern vom N. phrenicus unter der Einwirkung von Atropin untersucht. Dabei ergab sich: 1. Atropin führte in Dosen von 0,6; 1,2; 2,4 und 4,8 mg/kg i.v. zu einer dosisabhängigen Verlängerung der Impulsabstände und zu einer Abnahme der Spikezahlen in inspirationsaktiven Phrenicus-Motoneuronen. Die Atmungsfrequenz war demgegenüber nach Atropin gesteigert. 2. Bei Stimulation der Atmung durch Anoxie (12 Vol.- % O2) oder Hypercapnie (5 Vol.- % CO2) war die erreichbare Steigerung der Entladungsfrequenz und die Erhöhung der Spikezahlen nach Atropin (1,0 mg/kg) absolut eingeschränkt, die relativen Änderungen waren iedoch in beiden Fällen vor und nach Atropinbehandlung gleich. 3. N-Methylatropin(1,0 mg/kg)zeigte keine Wirkung auf die Entladungsfrequenz im N. phrenicus. 4. Nach Denervation des Carotissinus war die Reaktion auf Atropin unverändert. Die unterschiedliche Wirkung von Atropin auf die Atmungstiefe (Zunahme der Impulsabstände, Abnahme der Spikezahlen) und auf die Atmungsfrequenz (Steigerung der Atmungscyclen pro Zeiteinheit) scheint nicht durch eine Beeinflussung der Chemoreception, sondern durch eine direkte Wirkung an der zentralen Atmungsteuerung zustandezukommen.
    Notes: Abstract The effect of atropine on discharge pattern of phrenic motoneurons was investigated in rats after vagotomy. The following results were obtained: 1. Atropine increased the distance of impulses, while the number of spikes was reduced. This effect was dose dependent for 0.6, 1.2, 2.4, and 4.8 mg/kg atropine injected intravenously. At the same time the frequency of respiration increased after administration of atropine. 2. Following atropine the effect of O2-deficiency (12 Vol.-%O2) or CO2-excess (5 Vol.-% CO2 on frequency of impulses and number of spikes was absolutely reduced, but both reactions were relatively unchanged. 3. N-Methylatropine did not influence the discharge pattern in phrenic motoneurons. 4. The effect of atropine on frequency of impulses was also demonstrable after denervation of carotid sinus. The different effect of atropine on depth of respiration (increase in the distance of impulses, reduction of spike number) and respiratory frequency is not elicited by alteration of chemoreception. The results indicate that atropine effects the discharge pattern of phrenic motoneurons by direct action on central respiratory regulation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 263-275 
    ISSN: 1432-1912
    Keywords: Vasodilator Agents ; Oxygen Consumption ; Blood Flow ; Hindlimb ; Sympathectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of various vasodilating agents on the oxygen consumption was studied in the hindlimb of the cat. During the increase in flow by means of papaverine, acetylcholine, bradykinin, cobaltous chloride, isoprenaline, and phentolamine, an initial increase in the oxygen consumption for about 30 to 60 sec was observed. This phase was immediately followed by a sustained reduction in oxygen uptake below the control value although the blood flow remained increased. The diminution was greater than the initial elevation in oxygen uptake and was correlated with the increase in blood flow. An inhibition of the sympathetic constrictor nerve activity did not influence the biphasic changes in oxygen consumption due to the vasodilating agents. The blockade of the sympathetic vasoconstrictor tone led itself to a vasodilation, which was accompanied by an elevation of oxygen uptake during the whole period of flow increase. It is suggested that a shift in the pattern of flow within the extremity is responsible for these changes in oxygen consumption following the administration of the vasodilating agents tested here.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...