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  • 2005-2009  (1)
  • 1925-1929  (4)
  • 1890-1899  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction:  Cyclophilin C-associated protein (CyC-AP) expression is up-regulated during wound healing. CyC-AP deletion causes greater expression of TNFα, MMP-3, MMP-13, and MMP-14 during cutaneous repair. Furthermore, CyC-AP is a mediator for fibronectin-fragment induced MMP-13 expression. In order to understand the effects of the deletion of CyC-AP at the cellular level, we investigated the intracellular signal transduction pathways of CyC-AP null and wild-type mice during skin wound healing.Methods:  Two-month-old CyC-AP null or wild-type mice were anesthetized and two 0.6 cm diameter excisional skin wounds were made on the dorsum of each mouse. Wounds were collected up to 10 days after injury. Total protein was purified from each wound and the protein expression of TNFα converting enzyme (TACE), integrin beta 1, ERK 1, ERK 2, p38, PCNA, and smooth muscle actin (sm-actin) was analyzed by immunoblot.Results:  TNFα expression was higher in CyC-AP null mice in unwounded skin. However, the elevated TNFα in CyC-AP null wounds was lower compared to the wild-type mice. To further understand the relationship of CyC-AP and TNFα, TACE expression was examined. TACE expression was less in the skin of CyC-AP null mice compared to wild-type mice. Expression of p38 and PCNA increased while sm-actin decreased in both unwounded and wounded CyC-AP null skin compared to wild type. PCNA expression in CyC-AP null fibroblasts was also higher compared to wild type, supporting our in vivo observations. In addition, the expression of integrin beta 1 was lower during wound healing.Conclusion:  The increased PCNA and decreased sm-actin expression suggests that CyC-AP null fibroblasts have higher proliferation and lower differentiation rates compared to wild types. These effects might be regulated through the p38 signaling pathway, which was increased in CyC-AP null mice. The decreased TACE expression in CyC-AP null skin suggests CyC-AP may also regulate TACE via the altered expression of integrin beta 1. Our data suggest CyC-AP is involved in TNFα activation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 29 (1929), S. 23-32 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 46 (1928), S. 558-567 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Die Arbeit bringt eine weitere Teiluntersuchung der Alkali-Halogenia-Phosphore, die sich aus dem Schmelzfluß in Form großer einheitlicher Kristalle herstellen lassen und daher die optischen Energiestufen durch direkte optische Absorptionsmessungen festzustellen erlauben. Die Untersuchung vermeidet also im Sinne von Gudden und Pohl den speziellen Indikator der Phosphoreszenzemission. Es wird nicht die Erregungsverteilung ermittelt, sondern die Absorptionsspektra bei verschiedenen Temperaturen mit lichtelektrischer Photometrie ausgemessen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 115 (1927), S. 81-106 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 32 (1899), S. 3156-3163 
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 59 (1926), S. 2628-2635 
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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