ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Effects of glycolic acid on desquamation-regulating proteinases in human stratum corneum (2005)

Horikoshi, T. ; Matsumoto, M. ; Usuki, A. ; [et al.]

Oxford, UK; Malden, USA : Munksgaard International Publishers

Experimental dermatology 14 (2005), S. 0

add to mindlist on the mindlist

Details

ISSN: 1600-0625

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: In order to investigate the mechanism of glycolic acid (GA) function in human stratum corneum, we monitored changes in cathepsin D-like (CD) and chymotrypsin-like (SCCE) proteinases for 3 weeks following topical GA application (50% w/v, pH 0.9) for 30 min to human skin. In the early phase, weakened stratum corneum cohesion in the lower layers was observed on day 2 and the amount of active CD in the upper layer of the stratum corneum was significantly decreased from 30 min until day 2, whereas that in the lower layer remained normal. In contrast, the amount of active SCCE showed no change during the experimental period. The surface pH of the stratum corneum drastically decreased to pH 2 at 30 min and slightly recovered to around pH 3 until 1 day after treatment. From 9 to 19 days, a decrease in corneocyte cell area and a remarkable long-term increase in the amount of active CD in the upper layer were observed. In an in vitro study, the activities of desquamation-regulating proteinases were shown to have remarkably increased at around pH 3, due to activation of CD at its optimal pH. These results suggest that GA functions via at least two different mechanisms, acute activation of CD in the lower layer by acidification around pH 3, along with inactivation of CD in the upper layer, and long-term enhancement of de novo CD production in the few weeks following GA treatment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0906-6705.2005.00224.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Hydrogen-Induced Blistering of SiC: The Role of Post-Implant Multi-Step Annealing Sequences (2006)

Malouf, G. ; Poust, B. ; Hayashi, S. ; [et al.]

s.l. ; Stafa-Zurich, Switzerland

Materials science forum Vol. 527-529 (Oct. 2006), p. 855-858

add to mindlist on the mindlist

Details

ISSN: 1662-9752

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Hydrogen-exfoliation has become a viable approach to transfer SiC thin layers ontodifferent substrate materials. However, little attention has been paid to the exfoliation-inducingannealing conditions. To investigate the annealing conditions, 4H SiC wafers were implanted witheither 2.5×1016 H2+ cm-2 or 5.0×1016 cm-2at 37 KeV. Post-implant, multi-step annealing sequenceswere examined in order to promote more efficient blistering, and it was found that a lowtemperature initial annealing step (T ≈ 500°C) can decrease the annealing time necessary in thehigh temperature regime; this was attributed to a nucleation of hydrogen induced platelet defectsduring the low temperature annealing regime and efficient splitting during a higher temperature(900 °C) anneal. This process is similar to what is observed for InP and Si exfoliation, except thatthe annealing processes occur at higher temperature