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  • 2005-2009  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Insertion Behavior of Microneedles for Drug Delivery (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 1442-1445 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Drug dosage delivered by drug-coated microneedle is dependent on needle insertionbehavior. The insertion length and gripping force at varied insertion speeds are determinedquantitatively using a precision test frame. The ratio of inserted depth to pressed depth was foundto rise asymptotically to a plateau, but decreased rapidly to zero insertion when the needles arepressed less than 1000 microns deep for both silicone rubber and porcine skin. No insertion wasobserved when the needles are pressed less than 200 microns. The gripping force exerted onto theinserted needle by the skin decreased by 0.1N per mm of needle diameter and insertion depth. Theshort insertion depth and low force suggest that drug delivery using short 300 micron microneedleswould be tenuous. High insertion speeds can help to improve drug delivery, but the improvement islimited to large needles since the results from this study showed that insertions become speedindependentwhen the needle diameter is less than 130 microns
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1442.pdf
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Couple Stress Model of Steric Stiffening in Nanoporous Solids (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 730-733 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Porous solids are less stiff than the solid, but its stiffness can be increased if the elastic propertiesof the struts within are sterically stiffened. The stiffening behavior cannot be modeled by conventionalstrain-based finite element method but can be modeled using couple stress mechanics. In this investigation, anew finite element modeling approach (FEM) based on strain field similitude is developed. Theconventional displacement field was used to determine the steric rotation gradients and the additionalhigh-order deformation energy. The mechanics basis underpinning the methodology and the conditions ofapplicability were detailed, and the results were benchmarked with analytical solution and experimental data.Finally, the methodology was applied to a periodic cellular structure to demonstrate the effect of stericstiffening in nanoporous solids
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.730.pdf
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mechanics Framework for Micron-Scale Planar Structures (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 9 (Sept. 2005), p. 173-182 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Structures are assemblies of planar and three-dimensional objects. Planar components and parts are commonly because the deformation behaviors of plates and beams can be analyzed within the plane problem framework. For micron-scale structures, patterning processes in microfabrications are intrinsically planar and the resulting fabricated structures are also planar. These planar micron-scale structures have been designed and analyzed using conventional mechanics, but increasingly as the sizes of these structures become smaller, higher order effects become significant. In nanometer-scale, surfaces were recognized to play significant roles in affecting the physical behavior. Size dependent elastic and plastic deformation behaviors in micron-scale structures were also observed. Size dependence is an intrinsic part of higher order theory of mechanics and has been used successfully to explain scale dependent behavior in threedimensional structures. In this paper, two-dimensional higher order elastic relations in plane stress and plane strain for compressible solids are developed. The difference between the higher order and conventional elasticity theories is compared
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.9.173.pdf
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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