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  • 2005-2009  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 17 (2005), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Urocortin (Ucn) 2 is a new member of the corticotrophin-releasing hormone (CRH) neuropeptide family that is expressed in the central nervous system and peripheral tissues. However, the expression levels of Ucn 2 in various tissues of the rat remains unclear. Thus, the aim of the present study was to characterise the expression of Ucn 2 in the various tissues of the rat. Reverse transcriptase-polymerase chain reaction analysis demonstrated that Ucn 2 mRNA is expressed in the hypothalamus, pituitary, adrenal, stomach, skin, ovary, uterus and skeletal muscle. Histologically, Ucn 2 mRNA and Ucn 2-like immunoreactivity (LI) were demonstrated in both the anterior and intermediate lobes of the pituitary, but not detected in the posterior lobe. Furthermore, all Ucn 2-positive cells in the anterior and intermediate lobes were also positive for β-endorphin. Ucn 2 mRNA was detected in the adrenal cortex and medulla although Ucn 2-LI was only found in the adrenal medulla. High-performance liquid chromatography analysis of hypothalamic, pituitary, and adrenal extracts showed that the main Ucn 2-LI peak occurred at the same molecular size as that of synthetic Ucn 2. These results suggest that Ucn 2 is synthesised in various tissues, including the anterior and intermediate lobes of the pituitary and the adrenal.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 297-300 (Nov. 2005), p. 1598-1603 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In order to clarify the effect of anisotropy on local deformation and the stress intensity factors in the vicinity of the crack tip under complicated stress states, biaxial loading tests were carried out on isotropic (Photoelastic sheet: PSM-1, Measurements Group, Inc) and anisotropic (LEXAN 9030, General Electric Company) polycarbonate materials. The biaxial dynamic loading device, which was developed by the authors, was fully utilized in the experiments. We carried out the experiments using isotropic and anisotropic specimens with a pre-processed 0°, 15°, 30°, 45°, 60°, 75° or 90° crack angle. We applied the equal biaxial stress, that is, the loads for both the Y- and X-axis as 0N : 0N-3920N : 3920N (1 : 1). We determined the stress intensity factors of specimens using both photoelasticity and caustics method. The results of the experiments were compared. As a result, when the materials with anisotropic property are used as machine or structural members, it is important to consider the extrusion direction of the material in their design
    Type of Medium: Electronic Resource
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