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  • 1
    Electronic Resource
    Electronic Resource
    Design of surface forces apparatus for tribology studies combined with nonlinear optical spectroscopy (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2499-2504 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe the design, calibration, and performance of surface forces apparatus with the capability of illumination of the contact interface for spectroscopic investigation using optical techniques. The apparatus can be placed in the path of a Nd-YAG laser for studies of the linear response or the second harmonic and sum-frequency generation from a material confined between the two surfaces. In addition to the standard fringes of equal chromatic order technique, which we have digitized for accurate and fast analysis, the distance of separation can be measured with a fiber-optic interferometer during spectroscopic measurements (2 Å resolution and 10 ms response time). The sample approach is accomplished through application of a motor drive, piezoelectric actuator, or electromagnetic lever deflection for variable degrees of range, sensitivity, and response time. To demonstrate the operation of the instrument, the stepwise expulsion of discrete layers of octamethylcyclotetrasiloxane from the contact is shown. Lateral forces may also be studied by using piezoelectric bimorphs to induce and direct the motion of one surface. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148148
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  • 2
    Electronic Resource
    Electronic Resource
    Tobacco1: Natural Aging of Flue-Cured Cigarette Tobaccos (1936)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 28 (1936), S. 180-189 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50314a008
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  • 3
    Electronic Resource
    Electronic Resource
    FLUE–CURED TOBACCO Correlation between Chemical Composition and Stalk Position of Tobaccos Produced under Varying Weather Conditions1 (1936)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 28 (1936), S. 1214-1223 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50322a023
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  • 4
    Electronic Resource
    Electronic Resource
    Flue-cured Tobacco (1937)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 29 (1937), S. 1030-1039 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50333a014
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  • 5
    Electronic Resource
    Electronic Resource
    Hereditary ‘white nails’: a genetic and structural study (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Hereditary subtotal leuconychia is a rare nail disease. The gene(s) underlying this phenotype is (are) not known. Immunohistochemical and ultrastructural studies of nails are performed infrequently.Objectives  To perform genetic linkage analysis and to assess ultrastructure and soft/hard keratin expression in hereditary white nails.Methods  We have analysed microscopically and ultrastructurally the white nails of a patient from a family in which the trait is inherited in an autosomal dominant manner as an isolated symptom. No skin lesions or hair abnormalities could be detected. Genetic linkage studies were performed on DNA samples obtained from several members of the affected family. A longitudinal surgical biopsy of the nail from a great toe was split in two parts. One part was fixed in formalin and processed for histopathology. Another part was further subdivided and embedded either in Epon, following fixation in 2% glutaraldehyde, or in Lowicryl K4M, after fixation in 3% paraformaldehyde. Dewaxed nail sections and Lowicryl ultrathin sections were also stained with various antikeratin antibodies.Results  Genetic linkage studies of the family pointed to the disease gene mapping to the chromosomal 12q13 region. Genes mapping within this chromosomal region include the genes coding for type II (basic) cytokeratins and hard keratins. The nail matrix presented an abnormal hypergranulosis. The upper part of the nail plate, originating from the proximal nail matrix, had a nonhomogeneous lamellar appearance, with numerous intracellular ‘lipidic’ vacuoles and ‘empty’ spaces separating keratin filament bundles. These cells were progressively shed at the nail surface. The cell loss was compensated by hyperproliferation of the distal matrix and of the nail bed keratinocytes, with persistent marked parakeratosis and loose arrangement of keratin bundles. The distal matrix and the nail bed contributed equally to formation of the lower plate. This presented the characteristics of a tissue composed of soft keratins. Accordingly, there was virtually no labelling with the Hb1 antibody to a basic hard keratin in the white nail, whereas the labelling with AE3 antibody to all type II keratins and with KL1 recognizing suprabasal soft keratins was normal or even enhanced.Conclusions  Genetic linkage indicates that the gene defect underlying the leuconychia in the family studied resides on chromosome 12q13. As the type II keratins map within this chromosomal interval, it is possible that a mutation in one of these keratin genes may be a cause of the hereditary leuconychia. The white appearance of nails in this disease seems to be due to an abnormal keratinization of cells originating from the proximal nail matrix, leading to the presence of abundant intracellular vacuoles and to a lesser compactness of keratins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05994.x
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple idiopathic mucocutaneous neuromas: a new entity? (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 53-year-old woman who presented with multiple painful red cutaneous papules that had been growing slowly for 13 years. Histopathology showed typical features of neuroma. Biological, morphological and genetic investigations were negative and excluded the diagnosis of multiple endocrine neoplasia type 2b. After reviewing the literature, we concluded that our patient has an extremely unusual acquired disease, which must be considered as a distinct entity in the spectrum of cutaneous neurological disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04479.x
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  • 7
    Electronic Resource
    Electronic Resource
    Organization of the visual cortex (1996)
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 306-306 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - One long-standing question in developmental neuroscience is whether the functional architecture of the visual cortex is epigenetically induced by activity-dependent mechanisms or whether it is prespecified by genetic instructions1'2. It is widely assumed that dependence on experience and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/382306a0
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  • 8
    Electronic Resource
    Electronic Resource
    Spontaneous pinwheel annihilation during visual development (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 73-78 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/25736
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  • 9
    Electronic Resource
    Electronic Resource
    Three New Polymorphic Forms of Molybdenum Pentachloride (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 895-903 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Three new polymorphic modifications of molybdenum pentachloride could be obtained by solvothermal syntheses in CCl4 and SbCl5 as solvents. The structures have been solved by single-crystal X-ray diffraction. The already known structure of monoclinic \alpha-MoCl5 (C2/m) is not isomorphous with \alpha-NbCl5 and is better derived from the closest packing of Cl atoms of the Sm type with molybdenum occupying 1/5 of the octahedral holes. The triclinic structure of \beta-MoCl5 (P\overline 1) can be derived from hexagonal closest packing. The orthorhombic structure of \gamma-MoCl5 (Pnma) and the monoclinic structure of \delta-MoCl5 (P21/c) can both be derived from double-hexagonal closest packing. All four forms of MoCl5 have in common the discrete Mo2Cl10 moieties built from edge-sharing double octahedra with the metal atoms displaced from the octahedron centres away from each other. The differences between the modifications lie in the different stacking sequences of the close-packed Cl-atom layers and the different occupation of the octahedral interstices. This is reflected in the group–subgroup relationships of the space groups of the closest packings and the molybdenum pentachlorides. X-ray powder diffraction shows that sublimed MoCl5 is a mixture of all four modifications in variable amounts and probably a further unknown form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768197008331
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  • 10
    Electronic Resource
    Electronic Resource
    NMR monitoring of rheumatoid arthritis patients receiving anti-TNF-α monoclonal antibody therapy (1997)
    Springer
    Rheumatology international 16 (1997), S. 249-255 
    Details
    ISSN: 1437-160X
    Keywords: Dynamic MRI ; Rheumatoid arthritis ; Biological response modifiers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate if dynamic gadolinium-DTPA-supported magnetic resonance (MR) imaging can monitor the therapeutic effect of a fast-acting immuno-modulating drug like anti-tumour necrosis factor alpha (anti-TNF-α) monoclonal antibody (moab) in patients with rheumatoid arthritis (RA). Dynamic MR imaging was performed on 64 joints in a total of 18 patients before and after infusion with either a placebo or 1 or 10 mg/kg of anti-TNF-α moab. Additionally, treating the placebo group and reinfusing the verum group with either 3 or 10 mg/kg was monitored by quantitative nuclear magnetic resonance (NMR). Time-dependent signal intensity changes were then correlated with a total of five Paulus criteria and with ESR and C-reactive protein (CRP). No changes in either the gadolinium uptake or clinical parameters were seen after the infusion of a placebo. Therapy with 1 mg/kg anti-TNF-α moab resulted in a significant decrease in clinical disease activity, as well as in gadolinium-DTPA uptake in dynamic NMR studies. However, correlations between signal intensity changes and Paulus criteria were only demonstrated for the variable “doctor's evaluation of disease activity”. Patients given 10 mg/kg moab demonstrated a very significant improvement in all clinical manifestations of their disease, as well as a high significant reduction in gadolinium uptake (P=0.004). In addition, the latter group showed significant correlations between time-dependent signal intensity changes and five Paulus criteria: “number of swollen joints”, “number of painful joints”, “duration of morning stiffness”, “doctor's evaluation of disease activity” and “patient's evaluation of disease activity”. No differences and correlations were seen for ESR and CRP. We concluded that dynamic NMR studies are suitable to monitor inflammatory activity in RA patients under therapy with biological response modifiers such as anti-TNF-α moab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01375657
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