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  • 2000-2004
  • 1995-1999  (4)
  • 1910-1914
  • In-vitro-binding  (2)
  • Schlüsselwörter Infektionsprävention  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Morphine-6-O-β-D-glucuronide but not morphine-3-O-β-D-glucuronide binds to μ-, δ- and κ- specific opioid binding sites in cerebral membranes (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 192-197 
    Details
    ISSN: 1432-1912
    Keywords: µ-, δ-, κ-Opioid-Receptor ; Morphine ; Morphine-3-O-β-D-Glucuronide ; Morphine-6-O-β-D-Glucuronide ; Cerebral membranes ; In-vitro-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the nature of interaction of morphine-3-O-β-D-glucuronide (M3G) and morphine6-O-β-D-glucuronide (M6G) with opioid binding sites at the µ-, δ- and κ-opioid receptors (µ-OR, δ-OR and κ-OR) in cerebral membranes. Saturation binding experiments revealed a competitive interaction of M6G with all three opioid receptors. Inhibition binding experiments at the µ-OR employing combinations of morphine and M6G resulted in a rightward shift of the IC50 for morphine proportional to the M6G concentration, thus strengthening the finding of competitive interaction of M6G at the µ-opioid binding site. Data in absence and presence of M6G were included in a three-dimensional model. Compared to a model with one binding site a model with two binding sites significantly improved the fits. This might indicate that different µ-OR subtypes are involved. Hydrolysis of M6G to morphine was investigated and did not occur. Therefore the effects of M6G on binding to the μ-OR were due to M6G and not due to morphine. In contrast, M3G at the three opioid receptors was found to inhibit binding being about 300 times weaker than morphine. This effect was well explained by the amount of contaminating morphine (about 0.3%) identified by HPLC. We conclude that M6G binds to µ-, δ- and κ-OR in a competitive manner. Some of our results on the µ-OR suggest two binding sites for agonists at the μ-OR and that M6G binds to both sites. Our results suggest that the high potency of M6G as an analgesic is mediated through opioid receptors. In contrast, M3G does not interact with the µ-, δ- or κ-OR. We therefore doubt that any effect of M3G is mediated via opioid receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178720
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prävention katheterassoziierter Infektionen Die offiziellen amerikanischen Empfehlungen – fundierte Antworten auf alltägliche Fragen (1998)
    Springer
    Der Anaesthesist 47 (1998), S. 136-142 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Infektionsprävention ; Desinfektion ; Sepsis ; Komplikation ; Risikofaktoren ; Katheterwechsel ; Key words Infection prevention and control ; Disinfection methods ; Equipment Contamination ; Risk factors ; Septicemia ; catheters ; indwelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The official German guidelines for prevention of intravascular-device-associated infections were published by the Bundesgesundheitsamt, now called the Robert-Koch-Institut, 12 years ago. The recently published official „Guidelines for Prevention of Intravascular-Device Associated Infections” of the Centers for Disease Control and Prevention (CDC) are categorized according to scientific evidence. The American guidelines are very detailed and differ in some aspects from the offical German guidelines. The purpose of the present paper is to inform the German-speaking anaesthesiologist about the official CDC guidelines and to provide an update on the prevention of intravascular-device-associated infections.
    Notes: Zusammenfassung Die offiziellen deutschen Richtlinien zur Prävention katheterassoziierter Infektionen durch das frühere Bundesgesundheitsamt (jetzt Robert-Koch-Institut) sind mittlerweile 12 Jahre alt. Die kürzlich publizierten offiziellen Empfehlungen der amerikanischen Centers for Disease Control and Prevention (CDC) beruhen auf vorhandenen wissenschaftlichen Daten und sind daraufhin bezüglich ihrer Wertigkeit kategorisiert worden. Diese umfassenden Empfehlungen sind wesentlich ausführlicher als die offiziellen deutschen Richtlinien und weisen zu diesen teilweise beträchtliche Unterschiede auf. Mit dieser kurzen Darstellung der amerikanischen Richtlinien soll dem Kliniker für die eigene praktische Tätigkeit bezüglich vieler alltäglicher, aber keineswegs nebensächlicher Probleme eine fundierte Entscheidungshilfe zur Verfügung gestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050538
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Die offiziellen amerikanischen Empfehlungen zur Prävention nosokomialer Pneumonien (1998)
    Springer
    Der Anaesthesist 47 (1998), S. 925-935 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Infektionsprävention ; Pneumonie ; Risiokofaktoren ; Desinfektion ; Key words Infection prevention and control ; Pneumonia ; Disinfection methods ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The official German guidelines for prevention of nosocomial pneumonia were published by the Bundesgesundheitsamt, now called Robert-Koch-Institut, twelve years ago. The recently published official ”guidelines for prevention of nosocomial pneumonia” of the Centers for Disease Control and Prevention (CDC) are categorized according to scientific evidence. The American guidelines are very detailed and differ in some aspects from the official German guidelines. The purpose of the present paper is to inform the German anaesthesiologist about the official CDC guidelines and to provide a renewed background for the prevention of nosocomial pneumonia.
    Notes: Zusammenfassung Die offiziellen deutschen Richtlinien zur Prävention nosokomialer Pneumonien durch das frühere Bundesgesundheitsamt (jetzt Robert-Koch-Institut) sind mittlerweile 12 Jahre alt. Die kürzlich publizierten offiziellen Empfehlungen der amerikanischen Centers for Disease Control and Prevention (CDC) beruhen auf vorhandenen wissenschaftlichen Daten und sind daraufhin bezüglich ihrer Wertigkeit kategorisiert. Diese umfassenden Empfehlungen sind wesentlich ausführlicher als die offiziellen deutschen Richtlinien und weisen zu diesen teilweise beträchtliche Unterschiede auf. Mit dieser kurzen Darstellung der amerikanischen Richtlinien soll dem Kliniker für die eigene praktische Tätigkeit bezüglich vieler alltäglicher, aber keineswegs nebensächlicher Probleme eine fundierte Entscheidungshilfe zur Verfügung gestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050644
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Morphine-6-O-β-D-glucuronide but not morphine-3-O-β-D-glucuronide binds to μ-, δ- and κ- specific opioid binding sites in cerebral membranes (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 192-197 
    Details
    ISSN: 1432-1912
    Keywords: Key words μ- ; δ- ; κ-Opioid-Receptor ; Morphine ; Morphine-3-O-β-D-Glucuronide ; Morphine-6-O-β-D-Glucuronide ; Cerebral membranes ; In-vitro-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We investigated the nature of interaction of morphine-3-O-β-D-glucuronide (M3G) and morphine-6-O-β-D-glucuronide (M6G) with opioid binding sites at the μ-, δ- and κ-opioid receptors (μ-OR, δ-OR and κ-OR) in cerebral membranes. Saturation binding experiments revealed a competitive interaction of M6G with all three opioid receptors. Inhibition binding experiments at the μ-OR employing combinations of morphine and M6G resulted in a rightward shift of the IC50 for morphine proportional to the M6G concentration, thus strengthening the finding of competitive interaction of M6G at the μ-opioid binding site. Data in absence and presence of M6G were included in a three-dimensional model. Compared to a model with one binding site a model with two binding sites significantly improved the fits. This might indicate that different μ-OR subtypes are involved. Hydrolysis of M6G to morphine was investigated and did not occur. Therefore the effects of M6G on binding to the μ-OR were due to M6G and not due to morphine. In contrast, M3G at the three opioid receptors was found to inhibit binding being about 300 times weaker than morphine. This effect was well explained by the amount of contaminating morphine (about 0.3%) identified by HPLC. We conclude that M6G binds to μ-, δ- and κ-OR in a competitive manner. Some of our results on the μ-OR suggest two binding sites for agonists at the μ-OR and that M6G binds to both sites. Our results suggest that the high potency of M6G as an analgesic is mediated through opioid receptors. In contrast, M3G does not interact with the μ-, δ- or κ-OR. We therefore doubt that any effect of M3G is mediated via opioid receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178720
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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