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  • 1
    Electronic Resource
    Electronic Resource
    Prävention katheterassoziierter Infektionen Die offiziellen amerikanischen Empfehlungen – fundierte Antworten auf alltägliche Fragen (1998)
    Springer
    Der Anaesthesist 47 (1998), S. 136-142 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Infektionsprävention ; Desinfektion ; Sepsis ; Komplikation ; Risikofaktoren ; Katheterwechsel ; Key words Infection prevention and control ; Disinfection methods ; Equipment Contamination ; Risk factors ; Septicemia ; catheters ; indwelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The official German guidelines for prevention of intravascular-device-associated infections were published by the Bundesgesundheitsamt, now called the Robert-Koch-Institut, 12 years ago. The recently published official „Guidelines for Prevention of Intravascular-Device Associated Infections” of the Centers for Disease Control and Prevention (CDC) are categorized according to scientific evidence. The American guidelines are very detailed and differ in some aspects from the offical German guidelines. The purpose of the present paper is to inform the German-speaking anaesthesiologist about the official CDC guidelines and to provide an update on the prevention of intravascular-device-associated infections.
    Notes: Zusammenfassung Die offiziellen deutschen Richtlinien zur Prävention katheterassoziierter Infektionen durch das frühere Bundesgesundheitsamt (jetzt Robert-Koch-Institut) sind mittlerweile 12 Jahre alt. Die kürzlich publizierten offiziellen Empfehlungen der amerikanischen Centers for Disease Control and Prevention (CDC) beruhen auf vorhandenen wissenschaftlichen Daten und sind daraufhin bezüglich ihrer Wertigkeit kategorisiert worden. Diese umfassenden Empfehlungen sind wesentlich ausführlicher als die offiziellen deutschen Richtlinien und weisen zu diesen teilweise beträchtliche Unterschiede auf. Mit dieser kurzen Darstellung der amerikanischen Richtlinien soll dem Kliniker für die eigene praktische Tätigkeit bezüglich vieler alltäglicher, aber keineswegs nebensächlicher Probleme eine fundierte Entscheidungshilfe zur Verfügung gestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050538
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep (1998)
    Springer
    Intensive care medicine 24 (1998), S. 48-54 
    Details
    ISSN: 1432-1238
    Keywords: Key words Endotoxaemia ; Sepsis ; Nitric oxide ; Haemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The present study compared the effects of nitric oxide (NO) synthase inhibition and NO scavenging with haemoglobin in endotoxaemic sheep. Design: 12 sheep were instrumented for chronic study. Six sheep received l G-nitro-arginine-methylester (l-NAME, 2.5 mg/kg bolus followed by a continuous infusion of 0.5 mg/kg per h), the other 6 sheep received pyridoxalated haemoglobin polyoxyethylene conjugate (PHP, 100 mg/kg bolus followed by a continuous infusion of 20 mg/kg per h). Measurements and results: Haemodynamic and oxygenation parameters were measured in healthy sheep, after infusion of Salmonella typhosa endotoxin (10 ng/kg per min) for 24 h and after infusion of l-NAME or PHP. The infusion of endotoxin resulted in a hypotensive, hyperdynamic circulation. Infusion of l-NAME increased mean arterial pressure (MAP) from 76.1 ± 4.2 mmHg to normal values of 95.8 ± 5.7 mmHg (p 〈 0.05). PHP increased MAP from 73.0 ± 3.0 to 88.6 ± 4.7 mmHg (p 〈 0.05). This increase in MAP was associated in the l-NAME group with a more prominent drop in cardiac index (from 10.2 ± 0.4 to 7.0 ± 0.5 l · min–1· m–2; p 〈 0.05) than in the PHP group (from 10.7 ± 0.2 to 9.3 ± 0.6 l · min–1· m–2). During the first 90 min of infusion, cardiac index remained lower in the l-NAME group than in the PHP group. The increase in pulmonary vascular resistance was also higher in the l-NAME group. Conclusion: These results suggest, that at the doses used in the experiment, NO scavenging with PHP has smaller effects on cardiac index and pulmonary vascular resistance than NO synthase inhibition with l-NAME. Therefore, the concept of NO scavenging in hyperdynamic sepsis should be further evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050514
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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