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  • 2000-2004  (1)
  • 1995-1999  (1)
  • Bioincompatibility  (1)
  • Key words Cervical myelopathy  (1)
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  • 2000-2004  (1)
  • 1995-1999  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Orthopäde 25 (1996), S. 496-504 
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Zervikale Spondylose ; Myelopathie ; Pathoanatomie ; klinische Symptome ; Key words Cervical myelopathy ; Patho-anatomy ; Clinical symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Clinical symptoms and patho-anatomic changes in cervical myelopathy due to spondylotic changes are described. The leading symptoms are numbness and clumsiness of upper and lower extremity, mostly combined with gait disturbances. Muscle wasting primarily on the upper extremity leads to the myelopathic hand. Cervical myelopathy can be classified into five main groups: 1. Spastic tetraparesis with numbness and hyperreflexivity of upper and lower extremity. The majority of patients present with the myelopathic hand. 2. Spastic paraparesis with lesion below C6. 3. Spastic tetraparesis, mild or moderate, with deltoid muscle paresis. 4. Amyotrophic myelopathic hand with mild long tract signs. 5. Central cord syndrome due to cervical spondylosis combined with trauma. From the therapeutic aspect, conservative treatment is often unsuccessful. It is important to relieve pressure on the myelon, and decompressive procedures, especially posterior laminoplasty techniques, are required. Earlier surgery provides better results.
    Notes: Zusammenfassung Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt. Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veränderungen zurückzuführen. Periphere Symptome wie Radikulopathien können hinzukommen, wenn die lateralen Anteile des Spinalkanals eingeengt werden. Die Deltoideusparese Grad ≤ 3 (MMT) ist die häufigste Symptomatik von klinischer Bedeutung, wenn nur ein einzelner Muskel betroffen ist, die von der zervikalspondolytischen Radikulopathie verursacht wird. Bei der zervikalen Myelopathie stehen aber nicht Schmerz, sondern Funktionsstörungen im Vordergrund. Taubheitsgefühle an oberen und unteren Extremitäten sowie Gangstörungen sind Frühzeichen. Muskelatrophien werden vor allem an der oberen Extremität beobachtet und führen häufig zur sog. myelopathischen Hand. Der zervikale Myelopathie läßt sich in verschiedene Formen unterteilen: 1. spastische Tetraparese mit Symptomen der oberen und unteren Extremität, 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus, 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen, 5. zentrales Rückenmarksyndrom bei zervikaler Spondylose und Traumaanamnese. Therapeutisch sind konservative Maßnahmen wenig erfolgversprechend, es empfiehlt sich dekompressive Chirurgie. Die Prognose ist um so besser, je früher die Dekompression erfolgt.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7799
    Keywords: Key words Dialysis-related amyloidosis ; β2-Microglobulin ; β2-Microglobulin selective-adsorbent column ; Bioincompatibility ; PMN-elastase ; Myeloperoxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. It is well known that dialysis-related amyloidosis (DRA) is a serious major complication in long-term hemodialysis (HD) patients, and β2-microglobulin (MG) accumulation is recognized to be the major cause of DRA. Recently, a β2-MG selective adsorbent column has been developed for eliminating β2-MG from the circulating blood. We developed a novel enzyme immunoassay (EIA) method to measure myeloperoxidase (MPO), and observed the course of plasma MPO and polymorphonuclear leukocyte (PMN)-elastase concentrations as an index of the bioincompatibility of this column during treatment. Methods. Six patients undergoing maintenance HD participated in this study. Both proteins (MPO and PMN-elastase) were compared in patients receiving HD without this column and HD with this column. The concentrations were measured by EIA. The MPO assay was established in our laboratory, using our monoclonal anti-MPO antibody. Results. Both proteins were markedly elevated during HD with this column, compared with their concentrations in patients receiving HD without this column. Conclusion. Marked elevation of both MPO and PMN-elastase, indicating excessive granulocyte activation, was caused by the use of this column. It is possible that this phenomenon may lead to serious pathogenic conditions and progress to DRA in HD patients with long-term use of this column. At present, we have no data for long-term use. In future, the advantages and disadvantages of long-term use of this column should be investigated.
    Type of Medium: Electronic Resource
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