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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 20 (1994), S. 109-112 
    ISSN: 1432-1238
    Keywords: Myoglobin ; Rhabdomyolysis ; Kidney failure acute ; Haemofiltration ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Myoglobin kinetics of removal from the circulation were studied in patients following massive rhabdomyolysis, to see if myoglobin remains for long in the circulation in the anuric state and if myoglobin elimination was affected by therapeutic manipulation such as haemofiltration or haemodialysis. Design Randomised and controlled study. Setting Intensive care unit of a tertiary care teaching hospital. Patients 26 patients of rhabdomyolysis whose serum myoglobin exceeded more than 500 nmol/l. Thirteen patients developed acute renal failure and underwent treatment with blood purification (Group HD). The remaining 13 patients did not require treatment with blood purification (control subjects, Group non-HD). Interventions In patients of group HD, twelve were treated with haemofiltration and/or haemodialysis. One was treated with peritoneal dialysis. The patient of group non-HD were treated with fluid infusion alone. Measurements and results The serum concentrations of myoglobin were serially determined. The highest levels of myoglobin was 1641±484 nmol/l (mean±SEM) in the group non-HD and were 8957±2300 in the group HD. In the group non-HD, the blood myoglobin fell exponentially once myoglobin release into the circulation ceased. This was also noted in the group HD. The exponential decrease was observed even on the days when the patient passed little urine or treatment with blood purification was not performed. Conclusion In patients with massive myoglobinaemia, the blood myoglobin rapidly fell independent of renal function or any therapeutic manipulation. The results indicate that extrarenal factors played a major role in disposing circulating myoglobin in such patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Key words Coronary artery dissection ; Blunt chest trauma ; Acute myocardial infarction ; Myocardial contusion ; Coronary arteriography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a previously healthy 17-year-old woman who experienced coronary artery dissection with an acute transmural anterior myocardial infarction and myocardial contusion following blunt chest trauma in a motorcycle accident. A chest roentgenogram on admission was normal, and an electrocardiogram showed an acute transmural anterior myocardial infarction with complete right-bundle-branch block. A 2D echocardiogram revealed an akinesis of the anterior wall and a hypokinesis of the posterior wall in the left ventricle. Initial coronary angiography demonstrated severe stenosis with delayed antegrade filling in the proximal left anterior descending artery. Technetium-99m pyrophosphate myocardial scintigraphy demonstrated diffuse tracer uptake in the left ventricular wall. Follow-up coronary angiography performed 1 year after the accident showed a minor stenosis without any filling defects. We describe long-term follow-up of the coronary artery dissection following blunt chest trauma with spontaneous healing.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1238
    Keywords: Coronary artery dissection ; Blunt chest trauma ; Acute myocardial infarction ; Myocardial contusion ; Coronary arteriography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a previously healthy 17-year-old woman who experienced coronary artery dissection with an acute transmural anterior myocardial infarction and myocardial contusion following blunt chest trauma in a motorcycle accident. A chest roentgenogram on admission was normal, and an electrocardiogram showed an acute transmural anterior myocardial infarction with complete right-bundle-branch block. A 2D echocardiogram revealed an akinesis of the anterior wall and a hypokinesis of the posterior wall in the left ventricle. Initial coronary angiography demonstrated severe stenosis with delayed antegrade filling in the proximal left anterior descending artery. Technetium-99m pyrophosphate myocardial scintigraphy demonstrated diffuse tracer uptake in the left ventricular wall. Follow-up coronary angiography performed 1 year after the accident showed a minor stenosis without any filling defects. We describe long-term follow-up of the coronary artery dissection following blunt chest trauma with spontaneous healing.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Keywords: Arteriovenous malformation; cerebral haemorrhage; haematoma volume; angiography; computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Haemorrhage due to cerebral arteriovenous malformations (AVMs) varies from massive, requiring urgent operations, to clinically silent. The present study was designated to identify factors influencing haematoma size, and the pathophysiological mechanisms of massive haemorrhage were studied. 55 patients with intracerebral haematomas due to supratentorial AVMs were included in this study. Angiographic and clinical findings were retrospectively evaluated in relation to haematoma size.  Statistical analysis demonstrated that small size and the presence of only one draining vein were high risk factors for massive haemorrhage. The haematoma volume in small AVMs (30±4 cm3) was significantly larger than in other AVMs (7±3 cm3) (p=0.0005). AVMs with only one draining vein were associated with massive haematoma volume as compared to AVMs with two or more draining veins (30±4 versus 11±3 cm3, p=0.0023).  Our previous study demonstrated that feeding artery pressure (FAP) was significantly higher in AVMs with haemorrhage than in those without, as was draining vein pressure (DVP), and FAP and DVP were inversely related to the number of draining veins and the size of the AVMs. Thus, in small AVMs and AVMs with only one draining vein, local increase in DVP may thus contribute to massive haemorrhage.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 259 (1987), S. 157-163 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0014-5793
    Keywords: Purification: Liposome ; Ribosome ; Ribosome-binding protein ; Rough microsome
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron 49 (1993), S. 7649-7656 
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Orthopäde 25 (1996), S. 496-504 
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Zervikale Spondylose ; Myelopathie ; Pathoanatomie ; klinische Symptome ; Key words Cervical myelopathy ; Patho-anatomy ; Clinical symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Clinical symptoms and patho-anatomic changes in cervical myelopathy due to spondylotic changes are described. The leading symptoms are numbness and clumsiness of upper and lower extremity, mostly combined with gait disturbances. Muscle wasting primarily on the upper extremity leads to the myelopathic hand. Cervical myelopathy can be classified into five main groups: 1. Spastic tetraparesis with numbness and hyperreflexivity of upper and lower extremity. The majority of patients present with the myelopathic hand. 2. Spastic paraparesis with lesion below C6. 3. Spastic tetraparesis, mild or moderate, with deltoid muscle paresis. 4. Amyotrophic myelopathic hand with mild long tract signs. 5. Central cord syndrome due to cervical spondylosis combined with trauma. From the therapeutic aspect, conservative treatment is often unsuccessful. It is important to relieve pressure on the myelon, and decompressive procedures, especially posterior laminoplasty techniques, are required. Earlier surgery provides better results.
    Notes: Zusammenfassung Das klinische Erscheinungsbild der zervikalen Spondylose mit Myelopathie wird dargestellt. Die achsennahen Symptome wie Zervikalgie sind auf die radiologisch feststellbaren Veränderungen zurückzuführen. Periphere Symptome wie Radikulopathien können hinzukommen, wenn die lateralen Anteile des Spinalkanals eingeengt werden. Die Deltoideusparese Grad ≤ 3 (MMT) ist die häufigste Symptomatik von klinischer Bedeutung, wenn nur ein einzelner Muskel betroffen ist, die von der zervikalspondolytischen Radikulopathie verursacht wird. Bei der zervikalen Myelopathie stehen aber nicht Schmerz, sondern Funktionsstörungen im Vordergrund. Taubheitsgefühle an oberen und unteren Extremitäten sowie Gangstörungen sind Frühzeichen. Muskelatrophien werden vor allem an der oberen Extremität beobachtet und führen häufig zur sog. myelopathischen Hand. Der zervikale Myelopathie läßt sich in verschiedene Formen unterteilen: 1. spastische Tetraparese mit Symptomen der oberen und unteren Extremität, 2. spastische Paraparese bei Kompressionen unterhalb C6, 3. spastische Tetraparese mit Parese des M. deltoideus, 4. atropische Form der myelopathischen Hand mit Beteiligung der langen Bahnen, 5. zentrales Rückenmarksyndrom bei zervikaler Spondylose und Traumaanamnese. Therapeutisch sind konservative Maßnahmen wenig erfolgversprechend, es empfiehlt sich dekompressive Chirurgie. Die Prognose ist um so besser, je früher die Dekompression erfolgt.
    Type of Medium: Electronic Resource
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