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  • 2000-2004  (2)
  • 1995-1999  (1)
  • 1
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Harnblase ; Volumetrie ; Ultraschall ; Key words Urinary bladder ; Volumetry ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Experimental studies revealed that the contractile response of the urinary bladder to sacral anterior root stimulation depends on the actual bladder volume. Furthermore, no clinical relevant technique is available for continuous monitoring of the bladder wall distension respectively bladder volume in paraplegic patients. The presented study investigates the reliability of especially developed implantable ultrasound sensors as a sensoric system for continuous monitoring of the bladder volume. In six anaesthesized pigs two ultrasound sensors, one transmitter and one receiver, were implanted on the bladder wall at different locations (latero-lateral, dorsal-ventral, rostral-caudal). After closing the abdominal wall, the bladder was filled in 50 ml steps up to 250 ml. After each filling step the running time of the ultrasound signal was measured. In all experiments reproducible results and a high correlation of the measured running times with bladder volume were observed. The latero-lateral configuration of the sensors seemed to be most confidental. The presented study indicates that bladder volumetry with implantable ultrasound sensors is possible with minimal technical prerequisites. This promising technique for continuous bladder volumetry could play an important role in the development of an intelligent and autoadaptive neurostimulator of the urinary bladder in paraplegic patients.
    Notes: Zusammenfassung Experimentelle Studien haben gezeigt, daß die Kontraktionsantwort der Harnblase auf die sakrale Vorderwurzelstimulation abhängig ist vom Blasenfüllungszustand. Darüberhinaus ist derzeit keine zuverlässige Technik zur kontinuierlichen Registrierung des Blasenvolumens bei paraplegen Patienten verfügbar. Zur Prüfung der Zuverlässigkeit und Reproduzierbarkeit implantierbarer Ultraschallsensoren zur kontinuierlichen Registrierung des Blasenvolumens wurden bei 6 anästhesierten Schweinen 2 Ultraschallsensoren (1 Sender, 1 Empfänger) auf die Blasenaußenwand plaziert (laterolateral, dorsal-ventral, rostral-kaudal). Nach Verschluß der geöffneten Bauchdecke wurde die Harnblase in 50-ml-Schritten bis auf 250 ml gefüllt und nach jeder Füllung die Laufzeit des Ultraschallsignals gemessen. In jedem der durchgeführten Tierexperimente konnten reproduzierbare Signallaufzeiten pro Füllungsvolumen gemessen werden, wodurch der Blasenfüllungszustand mit minimalem technischem Aufwand bestimmt werden konnte. Darüberhinaus erwies sich die laterolaterale Sensorenplazierung als zuverlässig und Artefaktresistent. Diese Studie verdeutlicht, daß mit einfachem technischem Aufwand der aktuelle Blasenfüllungszustand mittels implantierbaren Ultraschallsensoren zu erfassen ist. Die vorgestellte Methode der kontinuierlichen Blasenvolumetrie stellt ein klinisch realisierbares Verfahren dar, das die Entwicklung eines autodaptativen Neurostimulators der Blase ermöglicht.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1335
    Keywords: p53 ; Tumor-suppressor gene ; Ovarian carcinoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The objective of this study was to analyze the incidence of immunohistochemically detectable p53 protein accumulation in epithelial ovarian carcinomas and to correlate these data with the clinical outcome so as to clarify further the role of p53 mutations in prognosis with these patients.Methods: Tumor tissues from 179 patients with epithelial ovarian carcinoma were used for immuno-histochemical analysis with monoclonal antibody DO1 and BP 53-12-1 on formalin-fixed, paraffin-embedded tissue.Results: A total of 78 cases (44%) showed positive nuclear p53 staining. The p53-positive cases were found in all histological types of epithelial ovarian tumors. p53 staining was found in tumors of all stages with a higher percentage of positive cases in stage IV ovarian carcinomas (not significant). Poorly differentiated carcinomas showed a significantly higher percentage of p53 protein expression than did highly differentiated tumors (P=0.0002). Clinical follow-up of up to 14 years (median 25 months) showed a slightly but not significantly shortened disease-free and overall survival time for patients with p53-positive epithelial ovarian carcinomas.Conclusions: We conclude from our data that p53 expression in ovarian carcinoma is associated with poor differentiation but not with the disease being in an advanced stage. There was a tendency for shortened disease-free and overall survival for patients with p53-positive tumors.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. A theory-experiment comparison for the intensity and polarization dependence of spectrally resolved transient four-wave-mixing signals is presented for a ZnSe single quantum well. Results for high intensities deviate from a simple model based on the optical Bloch equations for a five-level system whereas a microscopic theory for coherent excitonic and biexcitonic nonlinearities shows excellent agreement.
    Type of Medium: Electronic Resource
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