ISSN:
1573-7373
Keywords:
leucoencephalopaty
;
Methotrexate
;
central nervous system
;
craniospinal irradiation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00146878
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