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  • 1
    Electronic Resource
    Electronic Resource
    Kondensierte Ringsysteme, XV. Über die Reaktion von α-Chlorsulfoxiden mit Kalium-tert-butylat am Beispiel der Synthese von Oxapropellenen (1984)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 117 (1984), S. 966-981 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Condensed Ring Systems, XV. About the Reaction of α-Chloro Sulfoxides with Potassium tert-Butoxide by the Example of the Synthesis of OxapropellenesThe synthesis of dithia- 1a - 3a and oxathiapropellenes 1b - 3b is described. From 1b - 3b the α-chloro sulfoxides 4 - 6 and α-chloro sulfones 4a - 6a are prepared, or which in most cases several stereoisomeric racemates are obtained. The constitution, configuration, and conformation of the α-chloro sulfoxide 4, the main product obtained from 1b, was elucidated by X-ray structure analysis. Only in that way it was possible to deduce the constitutions and configurations of the other stereoisomeric α-chloro sulfoxides 4 - 6 and α-chloro sulfones 4a - 6a, respectively, using 13C NMR spectroscopy. By the reaction of the α-chloro sulfones 4a - 6a with potassium tert-butoxide (Ramberg-Bäcklund reaction) the corresponding oxapropellenes 7 - 9 are obtained only in low yields (〈 10%). Contrary, the α-chloro sulfoxides 4 - 6, und analogous conditions give yields of 80 - 90% (from 4, 6) and 25% (from 5).
    Notes: Es wird die Synthese der Dithia- 1a - 3a und Oxathiapropellene 1b - 3b beschrieben. Aus 1b - 3b werden die α-Chlorsulfoxide 4 - 6 und α-Chlorsulfone 4a - 6a hergestellt, von denen meist mehrere stereoisomere Racemate erhalten werden. Konstitution, Konfiguration und Konformation des Hauptprodukts der aus 1b erhaltenen α-Chlorsulfoxide 4 wurden durch Röntgenstrukturanalyse ermittelt. Erst dadurch wurde es möglich, mit Hilfe der 13C-NMR-Spektroskopie die Konstitutionen und Konfigurationen der anderen stereoisomeren α-Chlorsulfoxide 4 - 6 und α-Chlorsulfone 4a - 6a aufzuklären. Bei der Reaktion der α-Chlorsulfone 4a - 6a mit Kalium-tert-butylat (Ramberg-Bäcklund-Reaktion) erhält man die entsprechenden Oxapropellene 7 - 9 nur in geringer Ausbeute (〈 10%), während die α-Chlorsulfoxide 4 - 6 unter analogen Bedingungen Ausbeuten von 80 - 90% (aus 4, 6) und 25% (aus 5) ergeben.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19841170311
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  • 2
    Electronic Resource
    Electronic Resource
    Kondensierte Ringsysteme, XVI. Synthese, Kristall- und Molekularstruktur eines 1,4-überbrückten Dewar-Benzols der [6.2.2]Propellanreihe mit Konformationsenantiomerie (1984)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 117 (1984), S. 1868-1876 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Condensed Ring Systems, XVI1). Synthesis, Crystal and Molecular Structure of a 1,4-Bridged Dewar-Benzene of the [6.2.2]Propellane Series with Conformational EnantiomerismStarting from 3,4:5,6-dibenzo-10,13-dithia[6.3.3]propella-3,5-diene (1) racemic 3,4:5,6-dibenzo-[6.2.2]propella-3,5,9,11-tetraene (7) is prepared. Its constitution is established by X-ray structure analysis. An enantiomeric enrichment of 7 has been achieved by chromatography on triacetyl cellulose; its halflife at 20°C is about 100 h.
    Notes: Ausgehend von 3,4:5,6-Dibenzo-10,13-dithia[6.3.3]propella-3,5-dien (1) wird das racemische 3,4:5,6-Dibenzo[6.2.2]propella-3,5,9,11-tetraen (7) hergestellt. Seine Konstitution wird röntgenstrukturanalytisch bewiesen. Durch Chromatographie an Triacetylcellulose konnte eine Anreicherung der Enantiomeren von 7 erreicht werden, deren Halbwertszeit bei 20°C ca. 100 h beträgt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19841170514
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  • 3
    Electronic Resource
    Electronic Resource
    Radikalische Cyclisierung von Dienen, III Radikalische Cyclisierung von (R)-(-)-Carvon - Über den Einfluß von Charge-Transfer-Wechselwirkung auf den spezifischen Drehwert (1990)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 123 (1990), S. 901-905 
    Details
    ISSN: 0009-2940
    Keywords: Radical-type cyclisation / Bicyclo[3.2.]octan-3-one, enantiomerically pure / Charge-transfer interactions ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Radical-Type Cyclisation of Dienes, 111. - Radical-Type Cyclisation of (R)-( - )-Carvone - On the Influence of Charge- Transfer Interactions on the Optical RotationUnder the conditions of radical cyclisation, a 1:1 diastereomeric mixture of (1R,2S,5R,R)-(+)- (2a) and (1R.2S,5R,6S)-(+)-6-methoxy-2,6-dimethylbicyclo[3.2.1]octan-3-ones (2b) is obtained from (R)-(-)-carvone in 70% yield. the configuration fo 2a and 2b were confirmed by X-ray structure analyses of their hydrazones 2d and 2e. The regio- and stereoselectivity of the radical cyclisation of 1 to 2a and 2b are discussed. The high value of the specific rotation [-555] of 2d is traced back to charge-transfer interactions between the endo-standing methoxy group at C-6 as electron donor and the dinitrophenyl-hydrazone group as electron acceptor.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19901230441
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  • 4
    Electronic Resource
    Electronic Resource
    Asymmetrische Synthesen, V. Optisch aktive 5-Amino-4-phenyl-1,3-dioxane und deren Einfluß auf die Stereoselektivität der asymmetrischen Strecker-Synthese (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 710-721 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Asymmetric Syntheses, V. Optically Active 5-Amino-4-phenyl-1,3-dioxanes and Their Influence on the Stereoselectivity of the Asymmetric Strecker-SynthesisFrom (1S, 2S)-(+)-2-amino-1-phenyl-1,3-propanediol (1) and aldehydes or ketones 2a - e, respectively, the appropriate 5-amino-4-phenyl-1,3-dioxanes 3a - e are prepared. With benzaldehyde they form well crystallizing azomethines 4a - e. The conformation and configuration of 3a - e and 4a - e are deduced spectroscopically. From these results, and from investigations of the epimer equilibria 5a - e/6a - e conclusions are drawn about the stereochemical course of the asymmetric Strecker-synthesis.
    Notes: Aus dem (1S, 2S)-(+)-2-Amino-1-phenyl-1,3-propandiol (1) werden mit den Aldehyden bzw. Ketonen 2a - e die entsprechenden 5-Amino-4-phenyl-1,3-dioxane 3a - e hergestellt, die mit Benzaldehyd die gut kristallisierenden Azomethine 4a - e bilden. Die Konformation und Konfiguration von 3a - e und 4a - e werden spektroskopisch bestimmt. Aus diesen Ergebnissen und den Untersuchungen über das Epimerengleichgewicht 5a - e/6a - e lassen sich Rückschlüsse auf den stereochemischen Verlauf der asymmetrischen Strecker-Synthese ziehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801130228
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  • 5
    Electronic Resource
    Electronic Resource
    Asymmetrische Synthesen, VI. Synthese optisch aktiver Aziridine (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 722-727 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Asymmetric Syntheses, VI. Synthesis of Optically Active AziridinesThe optically active tetrahydro-1,4-oxazine derivatives 1a - e are converted via their respective tosylates 2a - e to the optically active aziridine derivatives 3a - e. The constitution and configuration of 3a - e are ascertained spectroscopically. The nitrogen inversion is investigated by low and high temperature 1H-NMR spectroscopy.
    Notes: Die optisch aktiven Tetrahydro-1,4-oxazin-Derivate 1a - e werden über die entsprechenden Tosylate 2a - e in die optisch aktiven Aziridin-Derivate 3a - e übergeführt. Die Konstitution und Konfiguration von 3a - e werden spektroskopisch ermittelt. Durch 1H-NMR-spektroskopische Tief-und Hochtemperaturmessungen wird die Inversion am Stickstoff untersucht.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801130229
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  • 6
    Electronic Resource
    Electronic Resource
    Radikalische Cyclisierung von Dienen, VIII. Über die regioselektive Herstellung von ungesättigten Cyclopenta[b]furan-2-onen aus (S)-(+)-Carvon  -  Bausteine zur Synthese von enantiomerenreinen Triquinanen (1994)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 549-550 
    Details
    ISSN: 0009-2940
    Keywords: Radicals ; Cyclization ; Triquinanes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Radical-Type Cyclization of Dienes, VIII[1].  -  On the Regioselective Synthesis of Unsaturated Cyclopenta[b]furan-2-ones from (S)-(+)-Carvone  -  Building Blocks for the Synthesis of Enantiomerically Pure TriquinanesThe diastereomeric products 2a and 2b, which were synthesized from (S)-(+)-carvone (1), are converted to (3aS,5S,6aS)-(-)-5-acetoxyhexahydro-6a-methyl-2H-cyclopenta[b]furan-2-one (4) in ca. 50% yield. 4 is regioselectively converted to (3aR,6aS)-(-)-3,3a,6,6a-tetrahydro-6a-methyl- (8a) and (3aS,6aR)-(+)-3,3a,4,6a-tetrahydro-6a-methyl-2H-cyclopenta[b]-furan-2-one (8b). These are used at the 10-g scale for the synthesis of enantiomerically pure triquinanes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19941270314
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  • 7
    Electronic Resource
    Electronic Resource
    Radikalische Cyclisierung von Dienen, IX. Über die Stereoselektivität der radikalischen 4-exo-trig-Cyclisierung von optisch aktiven (2E)-6-Oxohex-2-ensäureestern mit Samarium(II)-iodid (1994)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 1305-1309 
    Details
    ISSN: 0009-2940
    Keywords: Radicals ; Cyclobutanes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Radical-Type Cyclization of Dienes, IX. - On the Stereoselectivity of the Radical 4-exo-trig-Cyclization of Optically Active Ethyl (2E)-6-Oxohex-2-enoates with Samarium(II) IodideEthyl (5R, 2E)-5-(benzyloxy)-4,4-dimethyl-6-oxohex-2-enoate (9) was prepared from (R)-(-)-pantolactone (3) by a series of straightforward reactions. The reaction of 9 with samarium(II) iodide produces enantiomerically pure ethyl (1S,3R,4R)-(-)-[3-(benzyloxy)-4-hydroxy-2,2-dimethylcyclo-butyl]acetate (10) in 60% yield. The absolute configuration at C-1 and C-3 was confirmed by the conversion of 10 to the crystalline 15a, whose absolute configuration is known from its synthesis from (1S,5S)-( + )-α-pinene (12). The configuration of the hydroxy group at C-4 in 10 was determined from NOE studies on the epimiric 17. The radical 4-exo-trig-cyclization of optically active (2E)-6-oxohex-2-enoates with samarium(II) iodide opens a new pathway to enantiomerically pure cyclobutanol and cyclobutanone derivatives, which are of interest as building blocks in natural products synthesis.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19941270720
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  • 8
    Electronic Resource
    Electronic Resource
    Preparation of Kingiside from Aucubin (2000)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 2000 (2000), S. 1623-1626 
    Details
    ISSN: 1434-193X
    Keywords: Iridoid glucoside ; (8S)-Kingiside ; (8S)-Loganin ; (8S)-7-Ketologanin ; Asymmetric synthesis ; Natural products ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The tetraacetyl derivative 8 of the naturally occurring kingiside (8a) was prepared from aucubin (1). Intermediates in the synthesis were (8S)-tetraacetyl loganin (6) and (8S)-tetraacetyl-7-ketologanin (7), whose free (8R)-epimers occur in many different plants (Caprifoliaceae, Loganiaceae). The 13C NMR spectrum allows the structure to be unequivocally identified.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Asymmetrische Synthesen, VII. Herstellung optisch aktiver Aminonitrile (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 3098-3102 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Asymmetric Syntheses, VII1). Synthesis of Optically Active AminonitrilesThe optically active crystalline aminonitriles 3a-n and 4o are obtained from ketones 1a-o, (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-l,3-dioxane (2), and hydrocyanic acid. The absolute configuration of the newly formed centers of chirality (* in 3 and 4), and the epimer equilibria (table 1) in solution are determined by 1H NMR spectroscopy.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801130926
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  • 10
    Electronic Resource
    Electronic Resource
    Nichtproteinogene Aminosäuren, I. Eine einfache asymmetrische Synthese von (S)-(+)-2-Phenyl-und (S)-(+)-2-Anisylglycin (1980)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1980 (1980), S. 212-218 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Nonproteinogenic Amino Acids, I.  -  A Simple Asymmetric Synthesis of (S)-(+)-2-Phenyl-and (S)-(+)-2-AnisylglycineA three-step synthesis of optically pure (S)-(+)-2-phenyl- and (S)-(+)-2-anisylglycine (6a and b) is described. Although the yields are only about 50%, this synthesis nevertheless offers advantages over those involving a racemate cleavage.
    Notes: Es wird eine dreistufige Synthese des optisch reinen (S)-(+)-2-Phenyl- und (S)-(+)-2-Anisylglycins (6a bzw. b) beschrieben. Trotz Ausbeuten von nur ca. 50% bietet diese Synthese dennoch Vorteile gegenüber jenen mit Racematspaltung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198019800205
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