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Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma (2000)

Grote, H. J. ; Schneider-Stock, Regine ; Neumann, W. ; [et al.]

Springer

Virchows Archiv 436 (2000), S. 494-497

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ISSN: 1432-2307

Keywords: Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004280050478

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Stromträgerrelaxationen in hochohmigen Polymerfestkörpern (1991)

Neumann, W.

Weinheim : Wiley-Blackwell

Acta Polymerica 42 (1991), S. 639-645

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ISSN: 0323-7648

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Current carriers can cause currents after variation of the external electrical field, which depend on time just as relaxed dipols. The intensity and the position of the relaxation region and especially the nonlinear dependence between the stored charge and the external field are criterions for this. Blocking contacts cause relaxations of current carriers in poly(phenyl quinoxaline) and poly(ethylene terephthalate) samples. Detailed investigations of this phenomenon make possible informations on the density of the current carriers in the sample volume and on electrical properties of the contact region. Further ac-hopping is to be proved in poly(phenyl chinoxaline).

Notes: Neben relaxierenden Dipolen können auch Stromträger zeitabhängige Ströme nach Änderung des äußeren elektrischen Feldes bewirken. Als Kriterien dafür werden neben Intensität und Lage des Relaxationsgebietes die nichtlineare Abhängigkeit der gespeicherten Ladung von der äußeren Feldstärke angesehen. In Poly(chinoxalin) und Poly(ethylenterephthalat) werden Stromträgerrelaxationen durch blockierende Kontakte verursacht. Detaillierte Untersuchungen erlauben Aussagen über die Stromträgerdichte im Probenvolumen und Eigenschaften der Kontaktschicht. In Poly(chinoxalin) ist weiterhin Wechselstromhopping nachweisbar.

Additional Material: 13 Ill.