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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of p53 expression in endometrial carcinomas: correlation with markers of proliferating cells and clinicopathologic features (1993)
    238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Scientific Publications
    International journal of gynecological cancer 3 (1993), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using anti-p53 (PAb1801 and PAb240), anti-DNA polymerase α and Ki-67 monoclonal antibodies, the expression of p53 was studied in 11 normal endometria, 14 endometrial hyperplasias and 27 endometrial carcinomas and its relationship to the proliferative activity of the tumors was examined. Normal endometria and simple hyperplasias were completely negative for p53. The PAb1801 indices of complex hyperplasias and complex atypical hyperplasias were 2.5±1.8% and 5.0±3.2%, respectively. The PAb1801 indices of grade 1, grade 2 and grade 3 endometrial carcinomas were 10.2±14.2%, 44.4±29/0% and 45.0±32.5%, respectively. These results indicate a progressively enhanced p53 expression in the sequence from normal endometrium, through hyperplasia to carcinoma. A significant correlation between p53 expression and labeling indices of Ki-67 and DNA polymerase α was observed in endometrial carcinomas. The endo-metrial carcinomas with p53 overexpression developed mainly in post-menopausal patients and were frequently high-grade tumors with deep myometrial invasion. These findings may indicate that overexpression of p53 protein contributes to the proliferative activity of the tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1993.03060363.x
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  • 2
    Electronic Resource
    Electronic Resource
    Purinergic Regulation of Intracellular Ca2+ Concentration of Rat Pituitary Folliculo-Stellate Cells in Primary Culture (2001)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neuroendocrinology 13 (2001), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pituitary folliculo-stellate cells (FSCs) are glia-like cells in the anterior pituitary and are believed to modulate the activity of the pituitary endocrine cells. However, little is known what regulates the activity of FSCs. We hypothesized that ATP could act on FSCs, because ATP is coreleased with pituitary hormones from endocrine cells. To test this possibility, we examined the effect of ATP by measuring intracellular Ca2+ concentration [Ca2+]i of FSCs in primary culture. Both ATP and UTP increased the [Ca2+]i in a concentration-dependent manner in a range between 0.1 µM and 10 µM. The response was completely suppressed by thapsigargin, an inhibitior of endoplasmic reticulum Ca2+-ATPase, and was significantly suppressed by U-73122, an inhibitor of phospholipase C. The response was also suppressed by caffeine, a blocker of IP3 receptor, whereas that was not suppressed by ryanodine, an antagonist of ryanodine receptor. These results indicate that ATP increases [Ca2+]i of FSCs by activating phospholipase C via P2Y purinergic receptor and suggest that ATP would be one of paracrine factors to FSCs in the anterior pituitary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.2001.00639.x
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  • 3
    Electronic Resource
    Electronic Resource
    Chemometric Classification of L-Tryptophan Lots from Genetically Modified Bacillus amyloliquefaciens Strains (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 59 (1994), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Four types of L-tryptophan lots produced by genetically modified B. myloliquefaciens strains II-V, which consisted of case-associated (11) with manifestations of EMS, control (16), and other lots (11), were compared by multivariate computer recognition programs (chemometrics) including HCA, PCA, KNN and SIMCA, as well as PLS. In HCA data analysis lots from strains III and V formed discrete clusters, and in PCA and SIMCA, both lots formed separated groups. Lots from strains II and IV were included in a group of lots from strain III. This indicated strains II and IV too were closely related to strain III. When strain vs case-associated control or other lots were compared by four methods, SIMCA provided adequate strain separation and strains were well grouped in case-associated or control lots.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1994.tb08208.x
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  • 4
    Electronic Resource
    Electronic Resource
    Lung metastatic calcification in long-term dialysis patients, detected by single photon emission computed tomography (SPECT) (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 323-328 
    Details
    ISSN: 1437-7799
    Keywords: Key words Lung metastatic calcification ; SPECT ; Dialysis patients ; Pulmonary diffusion capacity ; Low PTH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Metastatic lung calcification (MLC) is an important complication in long-term dialysis patients, causing respiratory disturbance. We used single photon emission computed tomography (SPECT) in lung (L-SPECT) to detect the distribution of MLC. Methods. L-SPECT with 99mtechnetium hydroxymethylenediphosphonate was performed in 59 patients who had been on maintenance dialysis for more than 5 years. The accumulation count ratios were calculated from counts in the upper lung field (UL), lower lung field (LL), basal lung field along the diaphragm (BASE), and the cardiac pool (POOL). Distribution patterns of radionuclide were classified into four groups. Pulmonary function tests and blood examinations were performed. Results. The median values for UL/POOL, LL/POOL, and BASE/POOL were 1.71, 1.85, and 2.21, respectively. On the SPECT images, 28 patients had positive lung accumulation, versus 7 on the planar images. Patterns and frequency were: group I (none or slight accumulation), 32.2%; group II (accumulation only in the basal lung field), 33.8%; group III (accumulation in the whole lower lung or above), 18.6%; and group IV (diffuse accumulation extending to the whole lung field), 15.2%. Intact osteocalcin level was 6.3 ± 5.3 ng/ml in groups III + IV (large group) vs 94.2 ± 184.3 in groups I + II (small group) (P 〈 0.01). The number of patients with declining diffusion capacity was 20.0% in the large group, vs 5.1% in the small group. All patients in group IV had an intact parathyroid hormone (i-PTH) level of under 65 pg/ml. Conclusions. L-SPECT is very useful for the early detection of MLC, the extension of which may reduce diffusion capacity. Diffuse calcification over the whole lung is considered to be related to a low-turnover bone state concomitant with low PTH level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070009
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  • 5
    Electronic Resource
    Electronic Resource
    Electromyographic study of the mechanism of postoperative cholangitis in congenital biliary atresia (1990)
    Springer
    Pediatric surgery international 5 (1990), S. 433-436 
    Details
    ISSN: 1437-9813
    Keywords: Congenital biliary atresia ; Roux-en-Y biliary reconstruction ; Ascending cholangitis ; Intestinal motility ; Electromyographic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholangitis after biliary reconstruction for congenital biliary atresia is a troublesome postoperative complication. In order to clarify its mechanism and the changes in intestinal movement after biliary reconstruction by Roux-en-Y anastomosis, we performed electromyographic (EMG) studies of the motility of the reconstructed intestine in dogs. Monitoring the basic electrical rhythm (BER) and migrating myoelectric complexes (MMC), EMG analysis was carried out. As most of the Y-loop MMCs were propagated smoothly to the anal side, according to the continuity of the intestine, the intestinal contents were transported without stagnation. These intestinal movements appear to be useful as a biliary drainage route and to prevent ascending cholangitis. A comparison of short- and long-term intestinal motility after biliary reconstruction showed adaptation of the intestinal movement following the procedure. The outflow of bile appeared to accelerate intestinal motility because of prolongation of the MMC interval in the duodenum and oral jejunum without bile flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174343
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  • 6
    Electronic Resource
    Electronic Resource
    Infradiaphragmatic extralobar pulmonary sequestration in an infant (1992)
    Springer
    Pediatric surgery international 7 (1992), S. 58-60 
    Details
    ISSN: 1437-9813
    Keywords: Infradiaphragmatic extralobar pulmonary sequestration ; Retroperitoneal tumor ; Antenatal diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rare case of infradiaphragmatic pulmonary sequestration with an antenatally diagnosed abdominal tumor is reported. Extirpation of the tumor was performed 2 months after delivery; the histological examination showed alveolar and bronchial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181005
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of constant sustained positive airway pressure on right ventricular performance (1993)
    Springer
    Intensive care medicine 19 (1993), S. 8-12 
    Details
    ISSN: 1432-1238
    Keywords: Positive airway pressure ; Right ventricular ejection fraction ; Right ventricular performance ; Ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The detrimental effect of positive airway pressure on right ventricular (RV) performance is controversial and the aim of this study was to determine the effects of constant positive airway pressure without ventilatory fluctuation on RV performance with the aid of a pulmonary arterial catheter equipped with a rapid response thermistor for measuring RV ejection fraction (RVEF) and RV end-diastolic volume index (RVEDVI). Design A prospective, clinical study. Setting The central operating theatre of a university hospital. Patients Nine patients who had major surgery and required right heart catheterization for normal clinical management. Measurements and results Cold indicator was injected into the RV 4 or 5 times for each airway pressure (0, 10 or 20 cmH2O) which was maintained manually stable for 15 s, and 9 paired data were analyzed by repeated-measures analysis of variance. They are separated into two groups; RVEF at zero airway pressure greater (A group) or less (B group) than 0.4. In A group (7 patients), increasing airway pressures (0 vs 10 vs 20 cmH2O) did not affect RVEF (0.55±0.05 vs 0.54±0.06 vs 0.56±0.04), RVEDVI (69±36 vs 73±29 vs 58±20 ml·m−2), or stroke volume index (SVI: 38±18 vs 40±17 vs 33±13 ml·beat−1 ·m−2); however, in B (2 patients), RVEF (0.35 and 0.38 vs 0.31 and 0.28 vs 0.19 and 0.17) and SVI (35 and 28 vs 32 and 27 vs 27 and 23) decreased, while RVEDVI increased (99 and 73 vs 103 and 97 vs 146 and 132). Conclusions In most patients, the changes in RVEF, SVI, and RVEDVI did not occur under constant positive airway pressure, therefore the changes reported in mechanically ventilated patients may not attributable to the extent of positive airway pressure but rather to abrupt increases in airway pressure. There appears, however, to be patients whose RV function is so disturbed that they cannot cope with increased afterloads.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709271
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  • 8
    Electronic Resource
    Electronic Resource
    MR imaging of adrenoleukodystrophy (1991)
    Springer
    Neuroradiology 33 (1991), S. 25-29 
    Details
    ISSN: 1432-1920
    Keywords: Adrenoleukodystrophy ; Adrenomyeloneuropathy ; Magnetic resonance imaging ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed MRI in 7 cases with adrenoleukodystrophy (ALD), including 3 cases with childhood ALD, 3 cases with adrenomyeloneuropathy (AMN) and one symptomatic heterozygote. The symptomatic heterozygote was the mother of the patient with AMN. High-field-strength (2.0T) MRI was used in two cases with childhood ALD. In all 3 cases of childhood ALD, MR showed widespread lesions in both cerebral hemispheres. Areas of low intensity in the diencephalon or striatum on heavily T2-weighted images at 2.0T were seen in 2 cases with childhood ALD. Cerebral lesions confined to the internal capsule, cerebral peduncle and optic radiation in the adult onset ALD including AMN and symptomatic heterozygote, have not been reported and this confinement may indicate an early stage of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593329
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  • 9
    Electronic Resource
    Electronic Resource
    Electroencephalographic activity related to palatal myoclonus in REM sleep (1990)
    Springer
    Journal of neurology 237 (1990), S. 290-294 
    Details
    ISSN: 1432-1459
    Keywords: Palatal myoclonus ; EEG activity ; REM sleep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polysomnography, including electroencephalography, electromyography and electro-oculography was performed in three patients with palatal myoclonus (PM). The amplitude of the myoclonus decreased during sleep. The frequency did not change during non-REM sleep, but increased during REM sleep in two patients. Ocular myoclonus synchronized with PM disappeared during deep sleep stages in two patients and reappeared during REM sleep in one of them. In the other patient, ocular myoclonus was noted only in REM sleep, being absent even when the patient was awake. All patients showed episodic EEG activities synchronous with myoclonic jerks only in REM sleep. These episodes were noted 5–15 times throughout the night, and each episode lasting for 1–7 s. They were negative or positive waves of saw-tooth appearance which were distributed predominantly in the central region. During the episodes, the frequency of myoclonic jerks increased in two patients. Although it is known that REM sleep influences PM and ocular myoclonus, this is the first report demonstrating the electroencephalographic activity associated with PM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314744
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  • 10
    Electronic Resource
    Electronic Resource
    Isopower mapping of electrogastrograms in short-bowel syndrome (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 653-658 
    Details
    ISSN: 1741-0444
    Keywords: Electrogastrography ; Short-bowel syndrome ; Topographic EGG maps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Methods for making topographic or isopower electrogastrographic (EGG) maps and for obtaining maximum power foci (MPFs) by means of 27-channel EGG recordings are briefly described. The methods are applied to short-bowel syndrome (SBS). The gastro-intestinal tract is traced by videofluorograms after X-ray-opaque barium has been ingested. The MPFs are generally located on the trace of the gastrointestinal tract. The gastric area is occupied by 3 cycles min−1 (up to 28% of total MPFs) and 6 cycles min−1 MPFs (26%). The trace of the small intestine is occupied mainly by 8 cycles min−1 (39%) and 10 cycles min−1 (43%) MPFs. The trace of the colon is occupied almost evenly by all five spectral frequency groups, that is, by 1 (58%), 3 (53%), 6 (48%), 8 (57%) and 10 cycles min−1 (42%). Most interestingly, the numbers of 8–10 cycles min−1 power foci found on EGG maps (including MPFs and relatively higher power foci) are proportional to the remaining length at operation and to the length of the remaining small intestine in the long-term, over 6 years post-operatively. It is therefore possible to follow approximately the trace of the gasterointestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02344871
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