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  • 1
    Electronic Resource
    Electronic Resource
    Serum levels of IgE-binding factor (soluble CD23) in diseases associated with elevated IgE (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several in-vitro experiments suggest that the low affinity receptor for IgE (FcɛR II) and its soluble fragment (IgE-binding factor, IgE-BF) are multi-functional molecules and more particularly that they are capable of regulating the synthesis of human IgE. I nan attempt to examine the in-vivo significance of these in-vitro observations, the serum level of IgE-BF was measured in individuals with allergic or parasitic diseases, both associated with an increased production of IgE. IgE-BF was measured by a radioimmunoassay employing two mAbs against FcɛRII (mAbER). We first compared 257 allergic subjects to 172 non-allergic controls matched for age and sex. Statistical analysis of the data, after logarithmic transformation of IgE-BF and IgF. values, revealed that despite a great overlap, the allergic subjects had significantly higher levels of IgE-BF. The correlation between IgE and IgE-BF was very weak but significant. Allergic or non-allergic children had significantly higher IgE-BF levels than the corresponding groups of adults; moreover, the in verse correlation between age and IgE-BF levels was significant only in the children and not in the adults. The IgE-BF levels were not influenced by gender, by hyposensitization therapy or by treatment with local steroids. Subjects receiving systemic steroids had lower IgE-BF levels than untreated subjects. To assess the effect of seasonal exposure to allergen, IgE-BF levels were monitored for 1 year in six rye grass-sensitive hay fever subjects known to display a seasonal increase of both total serum IgE and of specific anti-Lol p I and Lol p II IgE antibodies. The levels oflgE-BF remained stable in the hay fever subjects as well as i n the non-allergic controls. Twenty subjects with filariasis and high serum IgE concentrations also displayed increased levels of serum IgE-BF when compared to control individuals. The serum IgE-BF detected by the RIA was not bound to IgE as shown by two independent observations: (1) they were not adsorbed on an anti-IgE immunoadsorbent column and no serum IgE was retained on an immunoadsorbent column coupled to mAb against IgE-BF; and (2) the serum molecules binding to mAbER-coated solid phase did not react with radiolabelled monoclonal or polyclonal anti-IgE, and reciprocally the serum molecules binding to anti-IgE-coated solid phase did not react with labelled mAbER. Taken collectively, the present data are compatible with, but do not add further support to, the hypothesis that IgE-BF may regulate the synthesis of human IgE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02800.x
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  • 2
    Electronic Resource
    Electronic Resource
    The relationship between postoperative results and bone dynamics in RA patients who underwent cementless Ortholoc II TKA: histomorphometric study (2000)
    Springer
    Modern rheumatology 10 (2000), S. 88-94 
    Details
    ISSN: 1439-7609
    Keywords: Key words Rheumatoid arthritis ; Osteoporosis ; Histomorphometric study ; Total knee arthroplasty ; Radiolucent line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously reported a histomorphometric study of iliac bone obtained at the time of cementless total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA). In this paper, we further extended our analysis to investigate the postoperative results and radiographs after TKA in association with bone metabolism. All the patients were female, ranging in age from 38 to 68 years (mean, 56.8 years). Histomorphometric results demonstrated that bone volume and trabecular thickness were decreased, whereas bone absorption and bone formation rate (BFR) were increased. The bone in patients with mutilating disease (MUD) showed remarkably increased bone turnover and osteoporosis compared with those of the more erosive subset (MES) patients. Sixteen out of the 20 patients were alive at the time of follow-up (follow-up period between 5 years 10 months and 8 years 11 months). Among them, 10 patients could be further examined. Radiolucent lines (RLL) were assessed by the modified Knee Society evaluation (scoring) system. The number of RLL (N-RLL) were correlated with BFR in morphometric examination. In addition, the weight-bearing zones in the N-RLL were more significantly correlated with BFR. The Japanese Orthopedic Association (JOA) score and pain score negatively correlated with eroded bone surface. The present study indicated that bone dynamics, rather than the bone volume at the time of TKA, were involved in the presence of RLL and in pain after surgery for TKA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650050005
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  • 3
    Electronic Resource
    Electronic Resource
    In-vitro and in-vivo antibiotic susceptibilities of Lyme disease Borrelia isolated in China (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 65-67 
    Details
    ISSN: 1437-7780
    Keywords: Key words Lyme disease ; Borrelia burgdorferi antibiotic susceptibilities ; China
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antibiotic susceptibilities of seven Borrelia burgdorferi sensu lato isolates from Ixodes persulcatus in China were examined by in-vitro microdilution minimum inhibition concentration (MIC) and macrodilution minimum bactericidal concentration (MBC) methods. All isolates tested were susceptible to amoxicillin, erythromycin, and minocycline. The MICs of these drugs for the Chinese isolates were 0.025–0.1 μg/ml, 〈0.012–0.05 μg/ml, and 〈0.012–0.05 μg/ml, respectively. The MBCs were 0.1–0.39 μg/ml, 〈0.012–0.2 μg/ml, and 0.025–0.39 μg/ml, respectively. The in-vivo antimicrobial susceptibilities of the Chinese Borrelia isolates to two test drugs, amoxicillin and minocycline, were evaluated using ddY mice. Mice were infected by subcutaneous inoculation into the right hind footpad. When infection was confirmed, the mice were treated by subcutaneous injection of the test drugs into the back. Amoxicillin and minocycline, which possessed high in-vitro activities against Lyme disease Borrelia, provided good protection against borreliosis in this animal model. Higher doses of these drugs resulted in elimination of the Lyme disease spirochete from all animals receiving this course of treatment. The 50% curative doses (CD50) of amoxicillin and minocycline were 8.7 mg/kg and 3.1 mg/kg, respectively. This suggested that amoxicillin and minocycline could be useful for the treatment of Chinese Borrelia infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101560050053
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