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  • 2000-2004
  • 1985-1989  (2)
  • glomerular filtration rate  (1)
  • glucose disposal  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Ketone bodies increase glomerular filtration rate in normal man and in patients with Type 1 (insulin-dependent) diabetes mellitus (1987)
    Springer
    Diabetologia 30 (1987), S. 214-221 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; glomerular filtration rate ; ketone bodies ; albumin excretion rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to investigate whether the administration of acetoacetic and hydrochloric acids in a group of control and Type 1 (insulin-dependent) diabetic patients influenced renal haemodynamics. Renal plasma flow increased from 657±88 to 762±81 ml·min−1. 1.73 m−2 in diabetic patients (p〈0.01) and from 590±71 to 691±135 in control subjects (p〈0.01). Glomerular filtration rate increased from 135±9 to 180±8 ml·min−1·1.73 m−2 in diabetic patients (p〈 0.001) and from 117±8 to 145±7 in control subjects (p〈0.01). Similar effects on renal haemodynamics, even if less pronounced, were observed with low dose acetoacetic but not with hydrochloric acid infusion. Total protein, β2-microglobulin but not albumin excretion rates were increased by acetoacetic acid. We conclude that an acute increase in blood concentration of ketone bodies within the range found in diabetic patients with poor metabolic control (1) increases renal plasma flow and glomerular filtration rate both in control subjects and diabetic patients and (2) causes a tubular proteinuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270418
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man (1985)
    Springer
    Diabetologia 28 (1985), S. 870-872 
    Details
    ISSN: 1432-0428
    Keywords: Hyperaminoacidaemia ; euglycaemic hyperinsulinaemic clamp ; glucose disposal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg−1· min−1, p〈0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291080
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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