ISSN:
1432-0428
Keywords:
Hyperaminoacidaemia
;
euglycaemic hyperinsulinaemic clamp
;
glucose disposal
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg−1· min−1, p〈0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00291080
