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  • 1
    Electronic Resource
    Electronic Resource
    Robust Statistical Methods to Discriminate Extreme Events in Geoelectrical Precursory Signals: Implications with Earthquake Prediction (2000)
    Springer
    Natural hazards 21 (2000), S. 247-261 
    Details
    ISSN: 1573-0840
    Keywords: Geoelectrical signals ; run theory ; seismic precursors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract In this study, we propose a robuststatistical method to discern anomalous patternsin geoelectrical time series measured in a seismicarea of the Southern Apennine chain. First, a filteringprocedure to remove seasonal effects related tometeo-climatic fluctuations was carried out.Then, we selected an autoregressive model able todescribe the time fluctuations of geoelectricalsignals and propose a method to obtain an objectiveestimate of probability of occurrence for each extremeevent detected in the time series. Our applications inSouthern Italy allow us to hypothesize that theambiguity of short-term prediction is within thecomplicated dynamics of the physical processresponsible for electrical anomalies observed on theearth's surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008157730467
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cytotoxicity of capsaicin in monkey kidney cells: lack of antagonistic effects of capsazepine and Ruthenium red (2000)
    Springer
    Archives of toxicology 74 (2000), S. 40-47 
    Details
    ISSN: 1432-0738
    Keywords: Key words Capsaicin ; Capsazepine ; Ruthenium red ; Cytotoxicity ; Vero cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Capsaicin is a natural product of Capsicum peppers, excitatory effects of which have been shown to be mediated by the recently cloned vanilloid receptor 1 (VR1). Since previous studies have shown that capsaicin inhibits protein synthesis, experiments were performed to investigate whether this effect is mediated by VR1 receptor on cultured monkey kidney cells (Vero cells). The capsaicin uptake was assessed in cellular homogenate and in medium by high-performance liquid chromatography (HPLC) separation and quantification on C18 reverse-phase column and fluorescence detection. Toxic effects were assessed by incorporation of [3H]L-leucine into cellular proteins in the presence of capsazepine, the VR1 vanilloid receptor antagonist and Ruthenium red or tyrosine or calcium. Capsazepine (1 to 256 μM) did not modify the uptake rate of capsaicin for incubation times up to 24 h and did not antagonize capsaicin-induced protein synthesis inhibition. It rather inhibited protein synthesis per se from 100 to 256 μM. Ruthenium red which blocks mitochondrial calcium uptake, inhibited protein synthesis and did not antagonise or increase synergistically the effects of capsaicin. Interestingly in a medium deprived of calcium and supplemented by calcium chloride (10–50 μM) the protein synthesis inhibition induced by capsaicin is antagonised somehow. There was no prevention of capsaicin diffusion into the cells. Tyrosine, which seems to be the best preventive agent of capsaicin inhibitory effects, prevents its metabolism but not its diffusion. Capsaicin might enter cells by diffusion and interfere with protein synthesis machinery by competition with tyrosine which in turn prevents the metabolism of capsaicin. The results of the present study suggest that cell responses to capsaicin may be transduced through at least two molecular pathways, one involving VR1, since the receptor antagonist capsazepine fails to prevent the inhibitory effect of capsaicin in Vero cells of renal origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050650
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 331 (1985), S. 20-22 
    Details
    ISSN: 1432-1912
    Keywords: Desipramine ; p-Chlorophenylalanine ; Locomotion ; Rat ; Beta receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The decrease in the B max value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with parachlorophenylalanine (pCPA). Acute administration of DMI significantly decreased locomotor activity in saline- and (pCPA)-pretreated rats. DMI-induced inhibition of locomotor activity was abolished in (pCPA)-pretreated rats chronically treated with DMI. Conversely, in pCPA-pretreated animals, acute DMI could still significantly decrease the locomotion of chronically DMI-treated rats. The data presented indicated that an intact serotoninergic system is required to enable antidepressant drugs to induce biochemical and behavioral changes following their chronic administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498847
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Accumulation of zinc-phthalocyanine (Zn-Pc) in the aorta of atherosclerotic rabbits (1989)
    Springer
    Lasers in medical science 4 (1989), S. 167-170 
    Details
    ISSN: 1435-604X
    Keywords: Zn(II)-phthalocyanine ; photosensitizer ; photodiagnosis atheroma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Phthalocyanines are structural analogs of porphyrins and are characterized by a closely similar mechanism of transport in the bloodstream. We evaluated the accumulation of liposomebound Zn(II)-phthalocyanine (Zn-Pc) by atherosclerotic aortas in rabbits. The biodistribution of intravenously injected Zn-Pc (0.023 mg/kg body weight) in the serum and some tissues resembled that previously observed for other experimental animals. Moreover, significant amounts of Zn-Pc were recovered from the aorta of the atherosclerotic and not of the normal rabbits. The maximum accumulation (circa 0.04μg of Zn-Pc g−1 tissue) was observed at 3 h after injection. We conclude that Zn-Pc might act as a fluorescence marker for atheromas and it has a potential as a phototherapeutic agent in atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032431
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Waste management modeling by MARKAL model: A case study for Basilicata Region (2000)
    Springer
    Environmental modeling and assessment 5 (2000), S. 19-27 
    Details
    ISSN: 1573-2967
    Keywords: emissions control strategies ; integrated resource management ; linear programming model ; municipal solid waste management ; MARKAL model application
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Air pollution is one of the most pressing environmental problems which affects likewise urban, industrial and rural areas. Environmental planners, regulators and decision makers need reliable, scientifically based tools to find out strategies for controlling air pollution in a cost-effective way, taking into account the whole productive system. In this framework the basic elements of energy-environmental planning have to be extended to include also waste processing technologies amongst the usually considered pollution sources. Bottom-up optimizing models, based on linear programming techniques and customized for specific cases, represent a powerful tool in energy-environmental management. This paper focuses on the integrated modeling of material flows and energy system performed on a local scale case study (Basilicata Region, Southern Italy) using the linear programming model IEA-MARKAL. We have evaluated the feasibility of the model in representing the waste management system to estimate the environmental impact of the waste processing technologies in the context of the whole productive system. A sensitivity analysis has been carried out to emphasize the connections between tariffs, waste disposal technologies assessment and atmospheric emissions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019093107590
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    Paper (German National Licenses)
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